Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India

Amit Rawat, Pandiarajan Vignesh, Madhubala Sharma, Deepti Suri, Ankur Kumar Jindal, Anju Gupta, Jitendra Kumar Shandilya, Biman Saikia, Prasad Taur, Ambreen Pandrowala, Vijaya Gowri, Mukesh Desai, Manasi Kulkarni, Umair Bargir, Priyanka Kambli, Manisha Madkaikar, Sagar Bhattad, Ananthvikas Jayaram, Deenadayalan Munirathnam, Meena SivasankaranRevathi Raj, Ramya Uppuluri, Harsha P Lashkari, Manas Kalra, Anupam Sachdeva, Koon Wing Chan, Kohsuke Imai, Osamu Ohara, Shigeaki Nonoyama, Yu Lung Lau, Surjit Singh

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic granulomatous disease (CGD) is an inherited defect in phagocytic
respiratory burst that results in severe and life-threatening infections in affected children. Single center studies from India have shown that proportion of autosomal recessive (AR) CGD is more than that reported from the West. Further, affected patients have high mortality rates due to late referrals and difficulties in accessing appropriate treatment. However, there is lack of multicentric collaborative data on CGD from India.
Original languageEnglish
Article number625320
JournalFrontiers in Immunology
DOIs
Publication statusPublished - 25-02-2021

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