Clinical profile of brucellosis from a tertiary care center in southern India

Vishwanath Sathyanarayanan, Abdul Razak, Kavitha Saravu, Shastry Barkur Ananthakrishna, M. Mukhyprana Prabhu, K. E. Vandana

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To highlight the spectrum of clinical manifestations, labs, complications, treatment and outcome of brucellosis. Methods: Retrospective study was conducted in Kasturba Medical College, Manipal University, Karnataka, India which included 68 confirmed cases of brucellosis from January 2006- April 2010. Diagnosis of brucellosis was made by culturing the sera/body fluids by standard BACTEC method (or) by testing the sera for Brucella agglutinins using the standard agglutination test (SAT). A titer of 1:320 or more was considered as significant. SPSS 16 was used for statistical analysis and Microsoft Excel for graphical representation. Results: Of the 68 patients, 46 (68%) were male and 22 (32%) were female patients with age distribution of 9-75 years. Forty four (64.7%) had history of contact with unpasteurized dairy products or infected animals. Symptoms included fever (68, 100%), myalgia (21, 31%), musculoskeletal symptoms (23, 34%), headache (16, 24%), gastrointestinal symptoms (19, 28%) and altered sensorium (3, 4%). Co-morbidities and associations included HIV positivity (2, 3%), type 2 diabetes mellitus (13, 19%), steroid therapy (3, 4%) and HBsAg positivity (8, 12%). Ten (15%) patients had cervical lymphadenopathy, 4(6%) had splenic enlargement, 6 (7%) had hepatomegaly, 19 (28%) had hepatosplenomegaly and 2(3%) got meningeal signs. Anaemia was observed in 39 (57.3%) cases, high erythrocyte sedimentation rate (ESR) was present in 55 (80.8%) cases, leucocytosis in 10(14.7%), leucopenia in 10(14.7%), thrombocytopenia in 23 (33.82%) and thrombocytosis in 2 (2.94%) cases. Conclusions: In countries like India, where brucellosis and tuberculosis are endemic; rapid, sensitive and highly specific diagnostic methods are required to make early diagnosis and prevent resistance as there is an overlap in therapy.

Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalAsian Pacific Journal of Tropical Medicine
Volume4
Issue number5
DOIs
Publication statusPublished - 01-05-2011

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Brucellosis
Tertiary Care Centers
India
Thrombocytosis
Agglutination Tests
Brucella
HIV-2
Hepatomegaly
Dairy Products
Agglutinins
Blood Sedimentation
Myalgia
Age Distribution
Leukocytosis
Leukopenia
Body Fluids
Hepatitis B Surface Antigens
Serum
Thrombocytopenia
Type 2 Diabetes Mellitus

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Clinical profile of brucellosis from a tertiary care center in southern India",
abstract = "Objective: To highlight the spectrum of clinical manifestations, labs, complications, treatment and outcome of brucellosis. Methods: Retrospective study was conducted in Kasturba Medical College, Manipal University, Karnataka, India which included 68 confirmed cases of brucellosis from January 2006- April 2010. Diagnosis of brucellosis was made by culturing the sera/body fluids by standard BACTEC method (or) by testing the sera for Brucella agglutinins using the standard agglutination test (SAT). A titer of 1:320 or more was considered as significant. SPSS 16 was used for statistical analysis and Microsoft Excel for graphical representation. Results: Of the 68 patients, 46 (68{\%}) were male and 22 (32{\%}) were female patients with age distribution of 9-75 years. Forty four (64.7{\%}) had history of contact with unpasteurized dairy products or infected animals. Symptoms included fever (68, 100{\%}), myalgia (21, 31{\%}), musculoskeletal symptoms (23, 34{\%}), headache (16, 24{\%}), gastrointestinal symptoms (19, 28{\%}) and altered sensorium (3, 4{\%}). Co-morbidities and associations included HIV positivity (2, 3{\%}), type 2 diabetes mellitus (13, 19{\%}), steroid therapy (3, 4{\%}) and HBsAg positivity (8, 12{\%}). Ten (15{\%}) patients had cervical lymphadenopathy, 4(6{\%}) had splenic enlargement, 6 (7{\%}) had hepatomegaly, 19 (28{\%}) had hepatosplenomegaly and 2(3{\%}) got meningeal signs. Anaemia was observed in 39 (57.3{\%}) cases, high erythrocyte sedimentation rate (ESR) was present in 55 (80.8{\%}) cases, leucocytosis in 10(14.7{\%}), leucopenia in 10(14.7{\%}), thrombocytopenia in 23 (33.82{\%}) and thrombocytosis in 2 (2.94{\%}) cases. Conclusions: In countries like India, where brucellosis and tuberculosis are endemic; rapid, sensitive and highly specific diagnostic methods are required to make early diagnosis and prevent resistance as there is an overlap in therapy.",
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Clinical profile of brucellosis from a tertiary care center in southern India. / Sathyanarayanan, Vishwanath; Razak, Abdul; Saravu, Kavitha; Ananthakrishna, Shastry Barkur; Mukhyprana Prabhu, M.; Vandana, K. E.

In: Asian Pacific Journal of Tropical Medicine, Vol. 4, No. 5, 01.05.2011, p. 397-400.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical profile of brucellosis from a tertiary care center in southern India

AU - Sathyanarayanan, Vishwanath

AU - Razak, Abdul

AU - Saravu, Kavitha

AU - Ananthakrishna, Shastry Barkur

AU - Mukhyprana Prabhu, M.

AU - Vandana, K. E.

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N2 - Objective: To highlight the spectrum of clinical manifestations, labs, complications, treatment and outcome of brucellosis. Methods: Retrospective study was conducted in Kasturba Medical College, Manipal University, Karnataka, India which included 68 confirmed cases of brucellosis from January 2006- April 2010. Diagnosis of brucellosis was made by culturing the sera/body fluids by standard BACTEC method (or) by testing the sera for Brucella agglutinins using the standard agglutination test (SAT). A titer of 1:320 or more was considered as significant. SPSS 16 was used for statistical analysis and Microsoft Excel for graphical representation. Results: Of the 68 patients, 46 (68%) were male and 22 (32%) were female patients with age distribution of 9-75 years. Forty four (64.7%) had history of contact with unpasteurized dairy products or infected animals. Symptoms included fever (68, 100%), myalgia (21, 31%), musculoskeletal symptoms (23, 34%), headache (16, 24%), gastrointestinal symptoms (19, 28%) and altered sensorium (3, 4%). Co-morbidities and associations included HIV positivity (2, 3%), type 2 diabetes mellitus (13, 19%), steroid therapy (3, 4%) and HBsAg positivity (8, 12%). Ten (15%) patients had cervical lymphadenopathy, 4(6%) had splenic enlargement, 6 (7%) had hepatomegaly, 19 (28%) had hepatosplenomegaly and 2(3%) got meningeal signs. Anaemia was observed in 39 (57.3%) cases, high erythrocyte sedimentation rate (ESR) was present in 55 (80.8%) cases, leucocytosis in 10(14.7%), leucopenia in 10(14.7%), thrombocytopenia in 23 (33.82%) and thrombocytosis in 2 (2.94%) cases. Conclusions: In countries like India, where brucellosis and tuberculosis are endemic; rapid, sensitive and highly specific diagnostic methods are required to make early diagnosis and prevent resistance as there is an overlap in therapy.

AB - Objective: To highlight the spectrum of clinical manifestations, labs, complications, treatment and outcome of brucellosis. Methods: Retrospective study was conducted in Kasturba Medical College, Manipal University, Karnataka, India which included 68 confirmed cases of brucellosis from January 2006- April 2010. Diagnosis of brucellosis was made by culturing the sera/body fluids by standard BACTEC method (or) by testing the sera for Brucella agglutinins using the standard agglutination test (SAT). A titer of 1:320 or more was considered as significant. SPSS 16 was used for statistical analysis and Microsoft Excel for graphical representation. Results: Of the 68 patients, 46 (68%) were male and 22 (32%) were female patients with age distribution of 9-75 years. Forty four (64.7%) had history of contact with unpasteurized dairy products or infected animals. Symptoms included fever (68, 100%), myalgia (21, 31%), musculoskeletal symptoms (23, 34%), headache (16, 24%), gastrointestinal symptoms (19, 28%) and altered sensorium (3, 4%). Co-morbidities and associations included HIV positivity (2, 3%), type 2 diabetes mellitus (13, 19%), steroid therapy (3, 4%) and HBsAg positivity (8, 12%). Ten (15%) patients had cervical lymphadenopathy, 4(6%) had splenic enlargement, 6 (7%) had hepatomegaly, 19 (28%) had hepatosplenomegaly and 2(3%) got meningeal signs. Anaemia was observed in 39 (57.3%) cases, high erythrocyte sedimentation rate (ESR) was present in 55 (80.8%) cases, leucocytosis in 10(14.7%), leucopenia in 10(14.7%), thrombocytopenia in 23 (33.82%) and thrombocytosis in 2 (2.94%) cases. Conclusions: In countries like India, where brucellosis and tuberculosis are endemic; rapid, sensitive and highly specific diagnostic methods are required to make early diagnosis and prevent resistance as there is an overlap in therapy.

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