Clinical profile of children with acute kidney injury in a tertiary care centre from southern India

Shrikiran Aroor, Kavya Kambham, Pushpa G. Kini, Shravan Kanaparthi

Research output: Contribution to journalArticle

Abstract

Introduction: Acute kidney injury/impairment (AKI) includes the entire spectrum of the syndrome from minor changes in markers of renal function to the requirement of renal replacement therapy. Objective: To study the incidence, clinical profile and outcome of AKI in the paediatric intensive care unit (PICU) of a tertiary care centre from South India. Method: A prospective observational study was conducted in a paediatric tertiary health care centre from South India. All children between 1 month and 18 years of age, admitted to the PICU from October 2015 to April 2016 were included in the study. Children with known pre-existing renal disease, children who underwent renal replacement therapy before admission and children admitted for postoperative care and who were discharged within 48 hours or against medical advice, were excluded from the study. Results: A total of 310 children was admitted to the PICU during the study period and 262 were considered for the study after excluding 48 cases. Male-female ratio in the study group was 1.12:1. At admission, AKI was present in 8% (21 out of 262), at 48 hours in 7.9% (20 out of 252, 10 children expired before 48hrs). Overall, pRIFLE criteria were observed in 31 (11.8%) out of 262 children during the hospital stay. The overall mortality rate of the study group was 9.2%. The length of PICU and hospital stay was significantly longer in children with AKI when compared to children without AKI (p-values 0.003 and < 0.001 respectively). Most common aetiology implicated in the present study was sepsis (64.5%).Conclusions: The incidence of AKI in the PICU of the tertiary centre from South India was 8%, the mortality rate was 9.2% and the most common aetiology implicated (64.5%) was sepsis.

Original languageEnglish
Pages (from-to)338-341
Number of pages4
JournalSri Lanka Journal of Child Health
Volume47
Issue number4
DOIs
Publication statusPublished - 01-01-2018

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Acute Kidney Injury
Tertiary Care Centers
India
Pediatric Intensive Care Units
Renal Replacement Therapy
Length of Stay
Sepsis
Kidney
Preexisting Condition Coverage
Mortality
Postoperative Care
Observational Studies
Cohort Studies
Prospective Studies
Pediatrics
Delivery of Health Care
Incidence

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Clinical profile of children with acute kidney injury in a tertiary care centre from southern India",
abstract = "Introduction: Acute kidney injury/impairment (AKI) includes the entire spectrum of the syndrome from minor changes in markers of renal function to the requirement of renal replacement therapy. Objective: To study the incidence, clinical profile and outcome of AKI in the paediatric intensive care unit (PICU) of a tertiary care centre from South India. Method: A prospective observational study was conducted in a paediatric tertiary health care centre from South India. All children between 1 month and 18 years of age, admitted to the PICU from October 2015 to April 2016 were included in the study. Children with known pre-existing renal disease, children who underwent renal replacement therapy before admission and children admitted for postoperative care and who were discharged within 48 hours or against medical advice, were excluded from the study. Results: A total of 310 children was admitted to the PICU during the study period and 262 were considered for the study after excluding 48 cases. Male-female ratio in the study group was 1.12:1. At admission, AKI was present in 8{\%} (21 out of 262), at 48 hours in 7.9{\%} (20 out of 252, 10 children expired before 48hrs). Overall, pRIFLE criteria were observed in 31 (11.8{\%}) out of 262 children during the hospital stay. The overall mortality rate of the study group was 9.2{\%}. The length of PICU and hospital stay was significantly longer in children with AKI when compared to children without AKI (p-values 0.003 and < 0.001 respectively). Most common aetiology implicated in the present study was sepsis (64.5{\%}).Conclusions: The incidence of AKI in the PICU of the tertiary centre from South India was 8{\%}, the mortality rate was 9.2{\%} and the most common aetiology implicated (64.5{\%}) was sepsis.",
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Clinical profile of children with acute kidney injury in a tertiary care centre from southern India. / Aroor, Shrikiran; Kambham, Kavya; Kini, Pushpa G.; Kanaparthi, Shravan.

In: Sri Lanka Journal of Child Health, Vol. 47, No. 4, 01.01.2018, p. 338-341.

Research output: Contribution to journalArticle

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