Abstract

Acute cholangitis is inflammation of biliary ductal system from infection with an associated biliary obstruction. This retrospective study was done to determine the factors responsible for cholangitis and the microbiological profile of the bile in patients with cholangitis. In the study involving 348 patients, 36.4% had associated malignancy. A total of 54% of the bile samples were positive for aerobic culture. Nearly 66-73% of the Escherichia coli and Klebsiella isolates were Extended spectrum beta lactamases (ESBL) producers. Two isolates of Candida spps were also obtained. Polymicrobial infection was seen in 31.5% of the culture positive cases. Ideal antibiotics in case of cholangitis would be those which are excreted in the bile such as third-generation cephalosporins, ureidopenicillins, carbapenems and fluoroquinolones to combat resistance and polymicrobial aetiology. Anti-fungal drugs may also be necessary if the patient is not responding to biliary decompression and antibacterial agents to prevent fungaemia.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalIndian Journal of Medical Microbiology
Volume32
Issue number2
DOIs
Publication statusPublished - 2014

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Cholangitis
Bile
Fungemia
Anti-Bacterial Agents
Carbapenems
Klebsiella
Fluoroquinolones
Biliary Tract
Cephalosporins
beta-Lactamases
Decompression
Coinfection
Candida
Retrospective Studies
Escherichia coli
Inflammation
Infection
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Microbiology (medical)

Cite this

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title = "Clinicomicrobiological analysis of patients with cholangitis",
abstract = "Acute cholangitis is inflammation of biliary ductal system from infection with an associated biliary obstruction. This retrospective study was done to determine the factors responsible for cholangitis and the microbiological profile of the bile in patients with cholangitis. In the study involving 348 patients, 36.4{\%} had associated malignancy. A total of 54{\%} of the bile samples were positive for aerobic culture. Nearly 66-73{\%} of the Escherichia coli and Klebsiella isolates were Extended spectrum beta lactamases (ESBL) producers. Two isolates of Candida spps were also obtained. Polymicrobial infection was seen in 31.5{\%} of the culture positive cases. Ideal antibiotics in case of cholangitis would be those which are excreted in the bile such as third-generation cephalosporins, ureidopenicillins, carbapenems and fluoroquinolones to combat resistance and polymicrobial aetiology. Anti-fungal drugs may also be necessary if the patient is not responding to biliary decompression and antibacterial agents to prevent fungaemia.",
author = "Shenoy, {S. M.} and S. Shenoy and S. Gopal and Tantry, {B. V.} and S. Baliga and A. Jain",
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Clinicomicrobiological analysis of patients with cholangitis. / Shenoy, S. M.; Shenoy, S.; Gopal, S.; Tantry, B. V.; Baliga, S.; Jain, A.

In: Indian Journal of Medical Microbiology, Vol. 32, No. 2, 2014, p. 157-160.

Research output: Contribution to journalArticle

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AU - Shenoy, S.

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AU - Jain, A.

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