Clonazepam associated hypothyroidism

Aforethought on a concealed dilemma

Rupam Gill, Dipanjan Bhattacharjee, Navin A. Patil, Shripathy M. Bhat

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Subclinical hypothyroidism or mild thyroid failure is a familiar problem, with a prevalence of 3-15% in a population without any known overt thyroid disorder. The prevalence increases with age and is relatively higher among females. Subclinical hypothyroidism is defined as serum thyroid stimulating hormone (TSH) levels above the upper limit of normal (4 mU/L) while the triiodothyronine (T3) and thyroxine (T4) enduring within the normal range. Additionally, there exists a log-linear relationship between TSH and circulating T3 and T4; hence, measurement of serum TSH becomes mandatory for diagnosing mild thyroid failure when free T3and T4 are lying within normal limits. Though, autoimmune thyroid disease is the most common cause for elevated TSH; thyroid functions can be afflicted by long-term consumption of drugs like lithium, amiodarone. The causal relationship between benzodiazepine class of drugs, particularly clonazepam and subclinical hypothyroidism has never been established clinically, yet there are some pre-clinical studies to claim the effect of benzodiazepine on thyroid functions; operating at various levels - hypothalamus, thyroid gland, peripheral cells and nuclear receptors. Henceforth, we would like to report a rare occurrence of subclinical hypothyroidism in an elderly female receiving clonazepam for her underlying psychiatric illness.

Original languageEnglish
Pages (from-to)222-225
Number of pages4
JournalJournal of Applied Pharmaceutical Science
Volume6
Issue number10
DOIs
Publication statusPublished - 01-01-2016

Fingerprint

Clonazepam
Hypothyroidism
Thyroid Gland
Thyrotropin
Benzodiazepines
Amiodarone
Thyroid Diseases
Triiodothyronine
Cytoplasmic and Nuclear Receptors
Serum
Thyroxine
Lithium
Pharmaceutical Preparations
Hypothalamus
Autoimmune Diseases
Psychiatry
Reference Values
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

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abstract = "Subclinical hypothyroidism or mild thyroid failure is a familiar problem, with a prevalence of 3-15{\%} in a population without any known overt thyroid disorder. The prevalence increases with age and is relatively higher among females. Subclinical hypothyroidism is defined as serum thyroid stimulating hormone (TSH) levels above the upper limit of normal (4 mU/L) while the triiodothyronine (T3) and thyroxine (T4) enduring within the normal range. Additionally, there exists a log-linear relationship between TSH and circulating T3 and T4; hence, measurement of serum TSH becomes mandatory for diagnosing mild thyroid failure when free T3and T4 are lying within normal limits. Though, autoimmune thyroid disease is the most common cause for elevated TSH; thyroid functions can be afflicted by long-term consumption of drugs like lithium, amiodarone. The causal relationship between benzodiazepine class of drugs, particularly clonazepam and subclinical hypothyroidism has never been established clinically, yet there are some pre-clinical studies to claim the effect of benzodiazepine on thyroid functions; operating at various levels - hypothalamus, thyroid gland, peripheral cells and nuclear receptors. Henceforth, we would like to report a rare occurrence of subclinical hypothyroidism in an elderly female receiving clonazepam for her underlying psychiatric illness.",
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Clonazepam associated hypothyroidism : Aforethought on a concealed dilemma. / Gill, Rupam; Bhattacharjee, Dipanjan; Patil, Navin A.; Bhat, Shripathy M.

In: Journal of Applied Pharmaceutical Science, Vol. 6, No. 10, 01.01.2016, p. 222-225.

Research output: Contribution to journalArticle

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