Clozapine-induced sialorrhea: Pathophysiology and management strategies

Samir Kumar Praharaj, Manu Arora, Sachin Gandotra

Research output: Contribution to journalReview article

80 Citations (Scopus)

Abstract

Rationale: Clozapine is an atypical antipsychotic agent with proven efficacy in refractory schizophrenia, but its widespread use is limited by adverse effects such as agranulocytosis, seizures, sedation, weight gain, and sialorrhea. Clozapine-induced sialorrhea (CIS) is bothersome and has socially stigmatizing adverse effects, which result in poor treatment compliance. The pathophysiology of this condition is poorly understood and the treatment options available are based mostly on case reports and open-label studies. Objective: To review the available studies on CIS. Method: All relevant studies available through PUBMED search supplemented with manual search were undertaken. Result: The clinical features, complications, assessment, pathophysiology, and management of CIS are discussed. Conclusion: Although the studies evaluating the therapeutic options has limitations and no drug has been found to be superior, judicious use of pharmacological agents along with behavioral methods will reduce this troublesome side effect and enhance compliance.

Original languageEnglish
Pages (from-to)265-273
Number of pages9
JournalPsychopharmacology
Volume185
Issue number3
DOIs
Publication statusPublished - 01-04-2006

Fingerprint

Sialorrhea
Clozapine
Agranulocytosis
Antipsychotic Agents
Compliance
Weight Gain
Schizophrenia
Seizures
Pharmacology
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Praharaj, Samir Kumar ; Arora, Manu ; Gandotra, Sachin. / Clozapine-induced sialorrhea : Pathophysiology and management strategies. In: Psychopharmacology. 2006 ; Vol. 185, No. 3. pp. 265-273.
@article{898a17891e744332927205f0f9353978,
title = "Clozapine-induced sialorrhea: Pathophysiology and management strategies",
abstract = "Rationale: Clozapine is an atypical antipsychotic agent with proven efficacy in refractory schizophrenia, but its widespread use is limited by adverse effects such as agranulocytosis, seizures, sedation, weight gain, and sialorrhea. Clozapine-induced sialorrhea (CIS) is bothersome and has socially stigmatizing adverse effects, which result in poor treatment compliance. The pathophysiology of this condition is poorly understood and the treatment options available are based mostly on case reports and open-label studies. Objective: To review the available studies on CIS. Method: All relevant studies available through PUBMED search supplemented with manual search were undertaken. Result: The clinical features, complications, assessment, pathophysiology, and management of CIS are discussed. Conclusion: Although the studies evaluating the therapeutic options has limitations and no drug has been found to be superior, judicious use of pharmacological agents along with behavioral methods will reduce this troublesome side effect and enhance compliance.",
author = "Praharaj, {Samir Kumar} and Manu Arora and Sachin Gandotra",
year = "2006",
month = "4",
day = "1",
doi = "10.1007/s00213-005-0248-4",
language = "English",
volume = "185",
pages = "265--273",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "3",

}

Clozapine-induced sialorrhea : Pathophysiology and management strategies. / Praharaj, Samir Kumar; Arora, Manu; Gandotra, Sachin.

In: Psychopharmacology, Vol. 185, No. 3, 01.04.2006, p. 265-273.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Clozapine-induced sialorrhea

T2 - Pathophysiology and management strategies

AU - Praharaj, Samir Kumar

AU - Arora, Manu

AU - Gandotra, Sachin

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Rationale: Clozapine is an atypical antipsychotic agent with proven efficacy in refractory schizophrenia, but its widespread use is limited by adverse effects such as agranulocytosis, seizures, sedation, weight gain, and sialorrhea. Clozapine-induced sialorrhea (CIS) is bothersome and has socially stigmatizing adverse effects, which result in poor treatment compliance. The pathophysiology of this condition is poorly understood and the treatment options available are based mostly on case reports and open-label studies. Objective: To review the available studies on CIS. Method: All relevant studies available through PUBMED search supplemented with manual search were undertaken. Result: The clinical features, complications, assessment, pathophysiology, and management of CIS are discussed. Conclusion: Although the studies evaluating the therapeutic options has limitations and no drug has been found to be superior, judicious use of pharmacological agents along with behavioral methods will reduce this troublesome side effect and enhance compliance.

AB - Rationale: Clozapine is an atypical antipsychotic agent with proven efficacy in refractory schizophrenia, but its widespread use is limited by adverse effects such as agranulocytosis, seizures, sedation, weight gain, and sialorrhea. Clozapine-induced sialorrhea (CIS) is bothersome and has socially stigmatizing adverse effects, which result in poor treatment compliance. The pathophysiology of this condition is poorly understood and the treatment options available are based mostly on case reports and open-label studies. Objective: To review the available studies on CIS. Method: All relevant studies available through PUBMED search supplemented with manual search were undertaken. Result: The clinical features, complications, assessment, pathophysiology, and management of CIS are discussed. Conclusion: Although the studies evaluating the therapeutic options has limitations and no drug has been found to be superior, judicious use of pharmacological agents along with behavioral methods will reduce this troublesome side effect and enhance compliance.

UR - http://www.scopus.com/inward/record.url?scp=33645097999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645097999&partnerID=8YFLogxK

U2 - 10.1007/s00213-005-0248-4

DO - 10.1007/s00213-005-0248-4

M3 - Review article

C2 - 16514524

AN - SCOPUS:33645097999

VL - 185

SP - 265

EP - 273

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 3

ER -