Cognitive deficits, depressive symptoms, insight, and medication adherence in remitted patients with schizophrenia

V. Settem, Haridas Karanadi, Samir Praharaj

Research output: Contribution to journalArticle

Abstract

Objective: To study the relationship between cognitive deficits, depressive symptoms, insight, and medication adherence in remitted patients with schizophrenia. Methods: Fifty-four patients aged 18-60 years, with schizophrenia in remission, were evaluated for adherence using the Medication Adherence Rating Scale (MARS), cognitive deficits using the Schizophrenia Cognition Rating Scale (SCoRS), depressive symptoms using the Calgary Depression Scale for Schizophrenia (CDSS), and insight using the Beck Cognitive Insight Scale. Results: Twenty-one (38.9%) patients were found to be nonadherent to their medication. A significant negative correlation was found between MARS total score with SCoRS attention/vigilance (r = -0.28), attitude toward negative side effects of the psychotropic medication with SCoRS total score (r = -0.36), SCoRS attention/vigilance (r = -0.27), verbal learning and memory (r = -0.32), reasoning and problem-solving (r = -0.30), and social cognition (r = -0.28). A significant negative correlation was found between CDSS total score with MARS total score (r = -0.50), medication adherence behavior (r = -0.44), and attitude toward negative side effects of psychotropic medication (r = -0.60). MARS total score significantly positively correlated with years in remission (r = 0.29). Conclusions: Poor medication adherence was seen in more than one-third of remitted patients with schizophrenia and was associated with global cognitive deficits, depressive symptoms, and the number of years in remission.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalIndian Journal of Psychiatry
Volume61
Issue number4
DOIs
Publication statusPublished - 01-07-2019

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Medication Adherence
Schizophrenia
Depression
Cognition
Verbal Learning

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

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title = "Cognitive deficits, depressive symptoms, insight, and medication adherence in remitted patients with schizophrenia",
abstract = "Objective: To study the relationship between cognitive deficits, depressive symptoms, insight, and medication adherence in remitted patients with schizophrenia. Methods: Fifty-four patients aged 18-60 years, with schizophrenia in remission, were evaluated for adherence using the Medication Adherence Rating Scale (MARS), cognitive deficits using the Schizophrenia Cognition Rating Scale (SCoRS), depressive symptoms using the Calgary Depression Scale for Schizophrenia (CDSS), and insight using the Beck Cognitive Insight Scale. Results: Twenty-one (38.9{\%}) patients were found to be nonadherent to their medication. A significant negative correlation was found between MARS total score with SCoRS attention/vigilance (r = -0.28), attitude toward negative side effects of the psychotropic medication with SCoRS total score (r = -0.36), SCoRS attention/vigilance (r = -0.27), verbal learning and memory (r = -0.32), reasoning and problem-solving (r = -0.30), and social cognition (r = -0.28). A significant negative correlation was found between CDSS total score with MARS total score (r = -0.50), medication adherence behavior (r = -0.44), and attitude toward negative side effects of psychotropic medication (r = -0.60). MARS total score significantly positively correlated with years in remission (r = 0.29). Conclusions: Poor medication adherence was seen in more than one-third of remitted patients with schizophrenia and was associated with global cognitive deficits, depressive symptoms, and the number of years in remission.",
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Cognitive deficits, depressive symptoms, insight, and medication adherence in remitted patients with schizophrenia. / Settem, V.; Karanadi, Haridas; Praharaj, Samir.

In: Indian Journal of Psychiatry, Vol. 61, No. 4, 01.07.2019, p. 335-341.

Research output: Contribution to journalArticle

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AB - Objective: To study the relationship between cognitive deficits, depressive symptoms, insight, and medication adherence in remitted patients with schizophrenia. Methods: Fifty-four patients aged 18-60 years, with schizophrenia in remission, were evaluated for adherence using the Medication Adherence Rating Scale (MARS), cognitive deficits using the Schizophrenia Cognition Rating Scale (SCoRS), depressive symptoms using the Calgary Depression Scale for Schizophrenia (CDSS), and insight using the Beck Cognitive Insight Scale. Results: Twenty-one (38.9%) patients were found to be nonadherent to their medication. A significant negative correlation was found between MARS total score with SCoRS attention/vigilance (r = -0.28), attitude toward negative side effects of the psychotropic medication with SCoRS total score (r = -0.36), SCoRS attention/vigilance (r = -0.27), verbal learning and memory (r = -0.32), reasoning and problem-solving (r = -0.30), and social cognition (r = -0.28). A significant negative correlation was found between CDSS total score with MARS total score (r = -0.50), medication adherence behavior (r = -0.44), and attitude toward negative side effects of psychotropic medication (r = -0.60). MARS total score significantly positively correlated with years in remission (r = 0.29). Conclusions: Poor medication adherence was seen in more than one-third of remitted patients with schizophrenia and was associated with global cognitive deficits, depressive symptoms, and the number of years in remission.

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