TY - JOUR
T1 - Coinage Metal N-Heterocyclic Carbene Complexes
T2 - Recent Synthetic Strategies and Medicinal Applications
AU - Nayak, Swarnagowri
AU - Gaonkar, Santosh L.
N1 - Funding Information:
S.N. would like to acknowledge the Department of Science and Technology, Government of India (Sanction no. DST/INSPIRE Fellowship/2018/IF180662 dated 25‐09‐2019) for a junior research fellowship under the DST‐INSPIRE scheme and Manipal Academy of Higher Education for financial support.
Publisher Copyright:
© 2020 Wiley-VCH GmbH
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/6
Y1 - 2021/5/6
N2 - New weapons are constantly needed in the fight against cancer. The discovery of cisplatin as an anticancer drug prompted the search for new metal complexes. The successful history of cisplatin motivated chemists to develop a plethora of metal-based molecules. Among them, metal-N-heterocyclic carbene (NHC) complexes have gained significant attention because of their suitable qualities for efficient drug design. The enhanced applications of coinage metal-NHC complexes have encouraged a gradually increasing number of studies in the fields of medicinal chemistry that benefit from the fascinating chemical properties of these complexes. This review aims to present recent developments in synthetic strategies and medicinal applications of copper, silver and gold complexes supported by NHC ligands.
AB - New weapons are constantly needed in the fight against cancer. The discovery of cisplatin as an anticancer drug prompted the search for new metal complexes. The successful history of cisplatin motivated chemists to develop a plethora of metal-based molecules. Among them, metal-N-heterocyclic carbene (NHC) complexes have gained significant attention because of their suitable qualities for efficient drug design. The enhanced applications of coinage metal-NHC complexes have encouraged a gradually increasing number of studies in the fields of medicinal chemistry that benefit from the fascinating chemical properties of these complexes. This review aims to present recent developments in synthetic strategies and medicinal applications of copper, silver and gold complexes supported by NHC ligands.
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U2 - 10.1002/cmdc.202000836
DO - 10.1002/cmdc.202000836
M3 - Review article
C2 - 33277791
AN - SCOPUS:85101213827
SN - 1860-7179
JO - Farmaco
JF - Farmaco
ER -
