Colonization or spontaneous resolution: Expanding the role for Burkholderia pseudomallei

Kushal Naha, Barkur Ananthakrishna Shastry, Kavitha Saravu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 19-year-old Asian Indian female presented with productive cough since the past one month and low grade fever since the past two weeks. She was diagnosed with pulmonary tuberculosis and treated with antitubercular drugs. Subsequently, delayed cultures of bronchoalveolar lavage fluid grew Burkholderia pseudomallei (B. pseudomallei). On follow up the patient reported significant subjective improvement and ESR progressively returned to normal. In summary, this case report raises two distinct and equally intriguing roles for B. pseudomallei, i.e. respiratory colonization and spontaneously resolving pulmonary infection. The pathogenic potential of B. pseudomallei, the etiologic agent of melioidosis, is well known. Confirmation of either colonization or spontaneous resolution, would potentially spare many patients unnecessary and expensive therapy with broad-spectrum antibiotics, and contribute to more rational usage of antibiotics, especially in co-infection with Mycobacterium tuberculosis and B. pseudomallei-two bacterial diseases with closely similar clinical, radiologic and histopathologic features.

Original languageEnglish
Pages (from-to)250-252
Number of pages3
JournalAsian Pacific Journal of Tropical Medicine
Volume7
Issue number3
DOIs
Publication statusPublished - 01-03-2014

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Burkholderia pseudomallei
Melioidosis
Antitubercular Agents
Anti-Bacterial Agents
Bronchoalveolar Lavage Fluid
Coinfection
Pulmonary Tuberculosis
Mycobacterium tuberculosis
Cough
Fever
Lung
Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "A 19-year-old Asian Indian female presented with productive cough since the past one month and low grade fever since the past two weeks. She was diagnosed with pulmonary tuberculosis and treated with antitubercular drugs. Subsequently, delayed cultures of bronchoalveolar lavage fluid grew Burkholderia pseudomallei (B. pseudomallei). On follow up the patient reported significant subjective improvement and ESR progressively returned to normal. In summary, this case report raises two distinct and equally intriguing roles for B. pseudomallei, i.e. respiratory colonization and spontaneously resolving pulmonary infection. The pathogenic potential of B. pseudomallei, the etiologic agent of melioidosis, is well known. Confirmation of either colonization or spontaneous resolution, would potentially spare many patients unnecessary and expensive therapy with broad-spectrum antibiotics, and contribute to more rational usage of antibiotics, especially in co-infection with Mycobacterium tuberculosis and B. pseudomallei-two bacterial diseases with closely similar clinical, radiologic and histopathologic features.",
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Colonization or spontaneous resolution : Expanding the role for Burkholderia pseudomallei. / Naha, Kushal; Shastry, Barkur Ananthakrishna; Saravu, Kavitha.

In: Asian Pacific Journal of Tropical Medicine, Vol. 7, No. 3, 01.03.2014, p. 250-252.

Research output: Contribution to journalArticle

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