Comparative effect of betadine ointment and sodium fusidate cream on experimentally induced burn wound in wistar rats

Shakta Mani Satyam, Laxminarayana Bairy Kurady

Research output: Contribution to journalArticle

Abstract

Antibacterial agents like sodium fusidate, framycetin, calcium mupirocin are used topically to treat burn wounds. But their effect on healing as such is not known. The main objective of the present study is to compare the effect of sodium fusidate cream and betadine ointment on experimentally created burn wound healing in Wistar rats. The rats were anesthetized with ketamine 50mg/kg/ip before wounding. Burn wounds were created by pouring hot molten wax into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals were divided in to three groups of six rats each. Group I did not receive any drug and served as control group. Group II and III received 25-30 mg of betadine ointment and 25-30 mg of sodiumffusidate cream respectively once daily for 21 days or till complete epithelization whichever was earlier. Wound contraction and period of epithelization was noted in all the three groups by observing the animals daily. A significanltdercese in epithetlization and increase in % of wound contraction was observed with sodium fusidate cream compared to control and betadine group.

Original languageEnglish
Pages (from-to)887-890
Number of pages4
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume6
Issue number6
Publication statusPublished - 2015

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Fusidic Acid
Povidone-Iodine
Ointments
Wistar Rats
Rats
Wounds and Injuries
Animals
Framycetin
Mupirocin
Control Groups
Waxes
Ketamine
Wound Healing
Molten materials
Metals
Anti-Bacterial Agents
Calcium
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Comparative effect of betadine ointment and sodium fusidate cream on experimentally induced burn wound in wistar rats",
abstract = "Antibacterial agents like sodium fusidate, framycetin, calcium mupirocin are used topically to treat burn wounds. But their effect on healing as such is not known. The main objective of the present study is to compare the effect of sodium fusidate cream and betadine ointment on experimentally created burn wound healing in Wistar rats. The rats were anesthetized with ketamine 50mg/kg/ip before wounding. Burn wounds were created by pouring hot molten wax into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals were divided in to three groups of six rats each. Group I did not receive any drug and served as control group. Group II and III received 25-30 mg of betadine ointment and 25-30 mg of sodiumffusidate cream respectively once daily for 21 days or till complete epithelization whichever was earlier. Wound contraction and period of epithelization was noted in all the three groups by observing the animals daily. A significanltdercese in epithetlization and increase in {\%} of wound contraction was observed with sodium fusidate cream compared to control and betadine group.",
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N2 - Antibacterial agents like sodium fusidate, framycetin, calcium mupirocin are used topically to treat burn wounds. But their effect on healing as such is not known. The main objective of the present study is to compare the effect of sodium fusidate cream and betadine ointment on experimentally created burn wound healing in Wistar rats. The rats were anesthetized with ketamine 50mg/kg/ip before wounding. Burn wounds were created by pouring hot molten wax into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals were divided in to three groups of six rats each. Group I did not receive any drug and served as control group. Group II and III received 25-30 mg of betadine ointment and 25-30 mg of sodiumffusidate cream respectively once daily for 21 days or till complete epithelization whichever was earlier. Wound contraction and period of epithelization was noted in all the three groups by observing the animals daily. A significanltdercese in epithetlization and increase in % of wound contraction was observed with sodium fusidate cream compared to control and betadine group.

AB - Antibacterial agents like sodium fusidate, framycetin, calcium mupirocin are used topically to treat burn wounds. But their effect on healing as such is not known. The main objective of the present study is to compare the effect of sodium fusidate cream and betadine ointment on experimentally created burn wound healing in Wistar rats. The rats were anesthetized with ketamine 50mg/kg/ip before wounding. Burn wounds were created by pouring hot molten wax into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals were divided in to three groups of six rats each. Group I did not receive any drug and served as control group. Group II and III received 25-30 mg of betadine ointment and 25-30 mg of sodiumffusidate cream respectively once daily for 21 days or till complete epithelization whichever was earlier. Wound contraction and period of epithelization was noted in all the three groups by observing the animals daily. A significanltdercese in epithetlization and increase in % of wound contraction was observed with sodium fusidate cream compared to control and betadine group.

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