Topical antibiotics like Sodium fusidate, Framycetin are used to treat burn wounds. But whether they influence healing of wounds is not known. The aim of the experiment to compare the effect of Sodium fusidate, Framycetin of Apex Laboratories Chennai, with that of available market preparations on experimentally induced burn wound healing in Wistar rats. Partial thickness burn wounds was inflicted, on Wistar rats under ketamine (50mg/kg/i.p), by pouring hot molten wax at 80°C into a metal cylinder of 300 mm2 circular opening placed on shaven back of the rat. Animals with partial thickness burn wounds were divided into 7 groups (n=10). Group I did not receive any drug and served as control group. Group II, III, IV, V, VI and VII received topical creams of Sodium fusidate A, Sodium fusidate B, Fucidic acid, Framycetin A, Framycetin B, and Framycetin respectively, twice a day for 21 days or till complete healing whichever was earlier. Sodium fusidate B and Framycetin A significantly decreased the duration of epithelialisation and increased % of wound contraction in comparison to the control group. This was confirmed by histopathology studies. Sodium fusidate and Framycetin possess significant wound healing properties.
|Number of pages||3|
|Journal||International Journal of Pharmaceutical Sciences Review and Research|
|Publication status||Published - 01-07-2011|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science