Comparative evaluation of oral clonidine and intravenous clonidine premedication in functional endoscopic sinus surgery

T. C. Balaraju, B. Ramdas, Reeja Thomas, Amit Garg, Sreekantha, B. Yogish, D. Sheetal, S. S. Avinash

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: This randomized single blind study was designed to assess the effect of oral and intravenous (IV) clonidine premedication on hemodynamic response to endotracheal intubation, per-operative hemodynamic stability and post-operative analgesic requirements. Materials and Methods: In this randomised single blind study, 60 ASA grade I and grade 2 patients were randomized into two groups. Group O received 3+g/kg oral clonidine 2 hours prior to induction and group I received 3+g/kg iv clonidine 15 minutes prior to induction. Anaesthesia was induced with thiopentone and maintained with oxygen and nitrous oxide with halothane. Heart rate and mean arterial pressure was noted prior to induction and 1 min, 5 min, 10 min, 30 min and every half hourly till the end of procedure. Post-operative sedation and the analgesic requirements were also assessed. Results: Perioperatively the mean heart rate was comparable between the two groups. The mean arterial pressure also was comparable between the two groups at all times except at 1 hr where the mean arterial pressure was higher in the oral group compared to the IV group. There was no difference between the two groups in VAS and sedation scores recorded at 30 min intervals till 2 h postoperatively. Time of requirement of first dose of analgesic was also similar between the groups. Conclusion: the administration of both oral clonidine and iv clonidine results in improved perioperative haemodynamic stability which are comparable in its effects.

Original languageEnglish
JournalInternational Journal of Pharma and Bio Sciences
Volume4
Issue number1
Publication statusPublished - 01-01-2013
Externally publishedYes

Fingerprint

Premedication
Clonidine
Surgery
Hemodynamics
Single-Blind Method
Analgesics
Arterial Pressure
Heart Rate
Intratracheal Intubation
Thiopental
Nitrous Oxide
Halothane
Oral Administration
Anesthesia
Oxygen

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Balaraju, T. C., Ramdas, B., Thomas, R., Garg, A., Sreekantha, Yogish, B., ... Avinash, S. S. (2013). Comparative evaluation of oral clonidine and intravenous clonidine premedication in functional endoscopic sinus surgery. International Journal of Pharma and Bio Sciences, 4(1).
Balaraju, T. C. ; Ramdas, B. ; Thomas, Reeja ; Garg, Amit ; Sreekantha ; Yogish, B. ; Sheetal, D. ; Avinash, S. S. / Comparative evaluation of oral clonidine and intravenous clonidine premedication in functional endoscopic sinus surgery. In: International Journal of Pharma and Bio Sciences. 2013 ; Vol. 4, No. 1.
@article{9cef6a31f4654609829d9ceedbd7503f,
title = "Comparative evaluation of oral clonidine and intravenous clonidine premedication in functional endoscopic sinus surgery",
abstract = "Aim: This randomized single blind study was designed to assess the effect of oral and intravenous (IV) clonidine premedication on hemodynamic response to endotracheal intubation, per-operative hemodynamic stability and post-operative analgesic requirements. Materials and Methods: In this randomised single blind study, 60 ASA grade I and grade 2 patients were randomized into two groups. Group O received 3+g/kg oral clonidine 2 hours prior to induction and group I received 3+g/kg iv clonidine 15 minutes prior to induction. Anaesthesia was induced with thiopentone and maintained with oxygen and nitrous oxide with halothane. Heart rate and mean arterial pressure was noted prior to induction and 1 min, 5 min, 10 min, 30 min and every half hourly till the end of procedure. Post-operative sedation and the analgesic requirements were also assessed. Results: Perioperatively the mean heart rate was comparable between the two groups. The mean arterial pressure also was comparable between the two groups at all times except at 1 hr where the mean arterial pressure was higher in the oral group compared to the IV group. There was no difference between the two groups in VAS and sedation scores recorded at 30 min intervals till 2 h postoperatively. Time of requirement of first dose of analgesic was also similar between the groups. Conclusion: the administration of both oral clonidine and iv clonidine results in improved perioperative haemodynamic stability which are comparable in its effects.",
author = "Balaraju, {T. C.} and B. Ramdas and Reeja Thomas and Amit Garg and Sreekantha and B. Yogish and D. Sheetal and Avinash, {S. S.}",
year = "2013",
month = "1",
day = "1",
language = "English",
volume = "4",
journal = "International Journal of Pharma and Bio Sciences",
issn = "0975-6299",
publisher = "International Journal of Pharma and Bio Sciences",
number = "1",

}

Balaraju, TC, Ramdas, B, Thomas, R, Garg, A, Sreekantha, Yogish, B, Sheetal, D & Avinash, SS 2013, 'Comparative evaluation of oral clonidine and intravenous clonidine premedication in functional endoscopic sinus surgery', International Journal of Pharma and Bio Sciences, vol. 4, no. 1.

Comparative evaluation of oral clonidine and intravenous clonidine premedication in functional endoscopic sinus surgery. / Balaraju, T. C.; Ramdas, B.; Thomas, Reeja; Garg, Amit; Sreekantha; Yogish, B.; Sheetal, D.; Avinash, S. S.

In: International Journal of Pharma and Bio Sciences, Vol. 4, No. 1, 01.01.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparative evaluation of oral clonidine and intravenous clonidine premedication in functional endoscopic sinus surgery

AU - Balaraju, T. C.

AU - Ramdas, B.

AU - Thomas, Reeja

AU - Garg, Amit

AU - Sreekantha,

AU - Yogish, B.

AU - Sheetal, D.

AU - Avinash, S. S.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Aim: This randomized single blind study was designed to assess the effect of oral and intravenous (IV) clonidine premedication on hemodynamic response to endotracheal intubation, per-operative hemodynamic stability and post-operative analgesic requirements. Materials and Methods: In this randomised single blind study, 60 ASA grade I and grade 2 patients were randomized into two groups. Group O received 3+g/kg oral clonidine 2 hours prior to induction and group I received 3+g/kg iv clonidine 15 minutes prior to induction. Anaesthesia was induced with thiopentone and maintained with oxygen and nitrous oxide with halothane. Heart rate and mean arterial pressure was noted prior to induction and 1 min, 5 min, 10 min, 30 min and every half hourly till the end of procedure. Post-operative sedation and the analgesic requirements were also assessed. Results: Perioperatively the mean heart rate was comparable between the two groups. The mean arterial pressure also was comparable between the two groups at all times except at 1 hr where the mean arterial pressure was higher in the oral group compared to the IV group. There was no difference between the two groups in VAS and sedation scores recorded at 30 min intervals till 2 h postoperatively. Time of requirement of first dose of analgesic was also similar between the groups. Conclusion: the administration of both oral clonidine and iv clonidine results in improved perioperative haemodynamic stability which are comparable in its effects.

AB - Aim: This randomized single blind study was designed to assess the effect of oral and intravenous (IV) clonidine premedication on hemodynamic response to endotracheal intubation, per-operative hemodynamic stability and post-operative analgesic requirements. Materials and Methods: In this randomised single blind study, 60 ASA grade I and grade 2 patients were randomized into two groups. Group O received 3+g/kg oral clonidine 2 hours prior to induction and group I received 3+g/kg iv clonidine 15 minutes prior to induction. Anaesthesia was induced with thiopentone and maintained with oxygen and nitrous oxide with halothane. Heart rate and mean arterial pressure was noted prior to induction and 1 min, 5 min, 10 min, 30 min and every half hourly till the end of procedure. Post-operative sedation and the analgesic requirements were also assessed. Results: Perioperatively the mean heart rate was comparable between the two groups. The mean arterial pressure also was comparable between the two groups at all times except at 1 hr where the mean arterial pressure was higher in the oral group compared to the IV group. There was no difference between the two groups in VAS and sedation scores recorded at 30 min intervals till 2 h postoperatively. Time of requirement of first dose of analgesic was also similar between the groups. Conclusion: the administration of both oral clonidine and iv clonidine results in improved perioperative haemodynamic stability which are comparable in its effects.

UR - http://www.scopus.com/inward/record.url?scp=84880827043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880827043&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84880827043

VL - 4

JO - International Journal of Pharma and Bio Sciences

JF - International Journal of Pharma and Bio Sciences

SN - 0975-6299

IS - 1

ER -