Aim: The aim of this study is to evaluate postobturation apical seal following intracanal irrigation with maleic acid (MA) or a combination of chlorhexidine (CHX) and ethylenediaminetetraacetic acid (EDTA). Materials and Methods: Thirty single-rooted human premolar teeth were decoronated and subjected to root canal instrumentation. Based on the final irrigating regimen, samples were divided into 3 groups: Group 1- Irritrol (EDTA + CHX), Group 2-7% MA, and Group 3-0.9% Saline (control). The samples were then obturated and placed in humidor for 7 days. Specimens were subjected to microleakage analysis at 24 h, 7 days, and 14 days using glucose filtration technique. The samples were then analyzed with a glucose kit in a calorimeter at 500 nm wavelength. Data were analyzed using one-way ANOVA, post hoc Tukey's test, post hoc Games-Howell test, and Bonferroni test. Results: There were overall significant differences in the mean scores among all the three groups (P < 0.001). Saline group demonstrated a significant higher leakage than that of MA followed by Irritrol. 14th day had significantly higher leakage when compared to 7th day with least being at 24 h. Conclusion: Final irrigation with Irritrol improved the postobturation apical seal when compared to 7% MA.
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