Comparative study of fasting plasma glucose concentration and glucose challenge test for screening gestational diabetes mellitus

Sujaya Sham, B. Poornima R. Bhat, Aruna Kamath

Research output: Contribution to journalArticle

Abstract

Background: To compare the sensitivity and specificity of fasting plasma glucose (FPG) with that of standard glucose challenge test (GCT). Materials and methods: Eighty-nine eligible pregnant women underwent GCT between 24th and 28th gestational week, followed by a diagnostic 3 hours 100 gm oral glucose tolerance test within 1 week. Out patient clinic in Father Muller Medical College Hospital, Mangalore. Data was analyzed for significance by chi-square test. Results: Fasting plasma glucose concentration at a threshold value of 90 mg/dl and GCT at recommended standard threshold of 140 mg/dl yielded sensitivities of 66.7% and 100% respectively and specificities of 87.3% and 46.5% respectively. Reducing the threshold value of FPG to 80 mg/dl increased the sensitivity of test to 91.7% with specificity of 54.9% which was comparable to standard GCT, in our study. Conclusion: Measuring FPG concentration using a cut-off of ≥ 80 mg/dl is an easier, tolerable and more cost effective procedure than GCT for detecting more severe cases of GDM, i.e. the diabetes mellitus group. In resource poor settings with population belonging to average risk or high risk category, FPG at a cut-off of 90 mg/dl can be used to screen GDM.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalJournal of SAFOG
Volume6
Issue number2
DOIs
Publication statusPublished - 01-08-2014
Externally publishedYes

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Gestational Diabetes
Fasting
Glucose
Chi-Square Distribution
Glucose Tolerance Test
Fathers
Pregnant Women
Diabetes Mellitus
Costs and Cost Analysis
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

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abstract = "Background: To compare the sensitivity and specificity of fasting plasma glucose (FPG) with that of standard glucose challenge test (GCT). Materials and methods: Eighty-nine eligible pregnant women underwent GCT between 24th and 28th gestational week, followed by a diagnostic 3 hours 100 gm oral glucose tolerance test within 1 week. Out patient clinic in Father Muller Medical College Hospital, Mangalore. Data was analyzed for significance by chi-square test. Results: Fasting plasma glucose concentration at a threshold value of 90 mg/dl and GCT at recommended standard threshold of 140 mg/dl yielded sensitivities of 66.7{\%} and 100{\%} respectively and specificities of 87.3{\%} and 46.5{\%} respectively. Reducing the threshold value of FPG to 80 mg/dl increased the sensitivity of test to 91.7{\%} with specificity of 54.9{\%} which was comparable to standard GCT, in our study. Conclusion: Measuring FPG concentration using a cut-off of ≥ 80 mg/dl is an easier, tolerable and more cost effective procedure than GCT for detecting more severe cases of GDM, i.e. the diabetes mellitus group. In resource poor settings with population belonging to average risk or high risk category, FPG at a cut-off of 90 mg/dl can be used to screen GDM.",
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Comparative study of fasting plasma glucose concentration and glucose challenge test for screening gestational diabetes mellitus. / Sham, Sujaya; Bhat, B. Poornima R.; Kamath, Aruna.

In: Journal of SAFOG, Vol. 6, No. 2, 01.08.2014, p. 75-78.

Research output: Contribution to journalArticle

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