Comparative study of transdermal drug delivery systems of resveratrol

High efficiency of deformable liposomes

Maira Gaspar Tosato, Julie V. Maya Girón, Airton A. Martin, Vamshi Krishna Tippavajhala, Mónica Fernández Lorenzo de Mele, Lelia Dicelio

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like avoiding gastrointestinal problems and first pass metabolism. However, its therapeutic potential is limited by its low solubility and low stability in water and the reduced permeability of stratum corneum. To overcome these inconveniences the encapsulation of this compound in a drug delivery system is proposed here. In order to find the best carrier for transdermal application of RSV various liposomal nanoparticulate carriers like conventional liposomes (L-RSV), deformable liposomes (LD-RSV), ultradeformable liposomes (LUD-RSV) and ethosomes (Etho-RSV) were assayed. Transmission electron microscopic (TEM) and dynamic light scattering (DLS) studies were performed to analyze the surface morphology of these carriers. Structural characterization for these formulations was performed by confocal Raman spectroscopy. The spectroscopic results were analysed in conjunction with calorimetric data to identify the conformational changes and stability of formulations in the different nanoparticles induced by the presence of RSV. Comparison of the results obtained with the different carrier systems (L-RSV, LD-RSV, LUD-RSV and Etho-RSV) revealed that the best RSV carrier was LD-RSV. The increase in the fluidity of the bilayers in the region of the hydrophobic chains of the phospholipid by ethanol probably facilitates the accommodation of the RSV in the bilayer and contributes to the improved encapsulation of RSV without affecting the mobility of this carrier.

Original languageEnglish
Pages (from-to)356-364
Number of pages9
JournalMaterials Science and Engineering C
Volume90
DOIs
Publication statusPublished - 01-09-2018

Fingerprint

Resveratrol
Liposomes
delivery
drugs
Encapsulation
Fluidity
Phospholipids
Dynamic light scattering
Antioxidants
Metabolism
Surface morphology
Raman spectroscopy
Ethanol
Anti-Inflammatory Agents
formulations
Solubility
cornea
Nanoparticles
accommodation
antioxidants

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Tosato, Maira Gaspar ; Maya Girón, Julie V. ; Martin, Airton A. ; Krishna Tippavajhala, Vamshi ; Fernández Lorenzo de Mele, Mónica ; Dicelio, Lelia. / Comparative study of transdermal drug delivery systems of resveratrol : High efficiency of deformable liposomes. In: Materials Science and Engineering C. 2018 ; Vol. 90. pp. 356-364.
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Comparative study of transdermal drug delivery systems of resveratrol : High efficiency of deformable liposomes. / Tosato, Maira Gaspar; Maya Girón, Julie V.; Martin, Airton A.; Krishna Tippavajhala, Vamshi; Fernández Lorenzo de Mele, Mónica; Dicelio, Lelia.

In: Materials Science and Engineering C, Vol. 90, 01.09.2018, p. 356-364.

Research output: Contribution to journalArticle

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AU - Tosato, Maira Gaspar

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