Comparing the anaesthetic and analgesic efficacy of caudal levobupivacaine and ropivacaine in paediatric patients

Sai Tejashree Veeravalli, B. V. Sunil, T. V. Shenoy

Research output: Contribution to journalArticle

Abstract

Introduction: Introduction of S enantiomer of bupivacaine is a major breakthrough in the history of local anaesthesia as the pharmacodynamics of these drugs were favourable in reducing the occurrence of cardiotoxicity, neurotoxicity and unintended motor blockade Aim: To compare efficacy, postoperative analgesia and postoperative motor blockade of 0.25% levobupivacaine with 0.25% ropivacaine in caudal block for children, scheduled for lower abdominal and lowerlimb surgeries. Materials and Methods: 80 children, ASA I–II, 1-10 years, weighing between 5-30 kg, scheduled for elective lower abdominal and lower limb surgeries were given single caudal injection of 1 mL/kg of either levobupivacaine or ropivacaine. Caudal block was given after general anaesthesia using sevoflurane as induction agent airway secured with laryngeal mask. Postoperative pain score was assessed using Children and Infants Postoperative Pain Scale (CHIPPS) scale in children less than 6 years and numerical scale for children more than 6 years. Motor recovery was assessed by modified Bromage scale. Results: Onset of analgesia, duration of analgesia, postoperative pain and motor blockade were comparable between the two groups, of 40 each. Analgesia time was within 5 minutes in both the groups. Duration of analgesia was 404.8±67.6 minutes for levobupivacaine and 413.5±44.4 minutes for ropivacaine, which was not significant statistically. Postoperative analgesia was same between the two groups. It took 120 minutes for complete postoperative motor recovery. The motor recovery between the two groups was statistically not significant at immediate postoperative period (p=0.111), at 60 minutes (p=0.692). Conclusion: We conclude that both 1 mL of 0.25% levobupivacaine and 0.25% ropivacaine provide similar effect caudal anaesthesia and analgesia with motor blockade for 120 minutes.

Original languageEnglish
Pages (from-to)UC05-UC09
JournalJournal of Clinical and Diagnostic Research
Volume12
Issue number6
DOIs
Publication statusPublished - 01-06-2018

Fingerprint

Pediatrics
Analgesia
Analgesics
Anesthetics
Postoperative Pain
Recovery
Surgery
Caudal Anesthesia
Anesthesia and Analgesia
Laryngeal Masks
Pharmacodynamics
Bupivacaine
Local Anesthesia
Enantiomers
Postoperative Period
General Anesthesia
Weighing
ropivacaine
levobupivacaine
Lower Extremity

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Veeravalli, Sai Tejashree ; Sunil, B. V. ; Shenoy, T. V. / Comparing the anaesthetic and analgesic efficacy of caudal levobupivacaine and ropivacaine in paediatric patients. In: Journal of Clinical and Diagnostic Research. 2018 ; Vol. 12, No. 6. pp. UC05-UC09.
@article{682111b8897246faaee71aba139e0c81,
title = "Comparing the anaesthetic and analgesic efficacy of caudal levobupivacaine and ropivacaine in paediatric patients",
abstract = "Introduction: Introduction of S enantiomer of bupivacaine is a major breakthrough in the history of local anaesthesia as the pharmacodynamics of these drugs were favourable in reducing the occurrence of cardiotoxicity, neurotoxicity and unintended motor blockade Aim: To compare efficacy, postoperative analgesia and postoperative motor blockade of 0.25{\%} levobupivacaine with 0.25{\%} ropivacaine in caudal block for children, scheduled for lower abdominal and lowerlimb surgeries. Materials and Methods: 80 children, ASA I–II, 1-10 years, weighing between 5-30 kg, scheduled for elective lower abdominal and lower limb surgeries were given single caudal injection of 1 mL/kg of either levobupivacaine or ropivacaine. Caudal block was given after general anaesthesia using sevoflurane as induction agent airway secured with laryngeal mask. Postoperative pain score was assessed using Children and Infants Postoperative Pain Scale (CHIPPS) scale in children less than 6 years and numerical scale for children more than 6 years. Motor recovery was assessed by modified Bromage scale. Results: Onset of analgesia, duration of analgesia, postoperative pain and motor blockade were comparable between the two groups, of 40 each. Analgesia time was within 5 minutes in both the groups. Duration of analgesia was 404.8±67.6 minutes for levobupivacaine and 413.5±44.4 minutes for ropivacaine, which was not significant statistically. Postoperative analgesia was same between the two groups. It took 120 minutes for complete postoperative motor recovery. The motor recovery between the two groups was statistically not significant at immediate postoperative period (p=0.111), at 60 minutes (p=0.692). Conclusion: We conclude that both 1 mL of 0.25{\%} levobupivacaine and 0.25{\%} ropivacaine provide similar effect caudal anaesthesia and analgesia with motor blockade for 120 minutes.",
author = "Veeravalli, {Sai Tejashree} and Sunil, {B. V.} and Shenoy, {T. V.}",
year = "2018",
month = "6",
day = "1",
doi = "10.7860/JCDR/2018/34700.11652",
language = "English",
volume = "12",
pages = "UC05--UC09",
journal = "Journal of Clinical and Diagnostic Research",
issn = "2249-782X",
publisher = "Journal of Clinical and Diagnostic Research",
number = "6",

}

Comparing the anaesthetic and analgesic efficacy of caudal levobupivacaine and ropivacaine in paediatric patients. / Veeravalli, Sai Tejashree; Sunil, B. V.; Shenoy, T. V.

In: Journal of Clinical and Diagnostic Research, Vol. 12, No. 6, 01.06.2018, p. UC05-UC09.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparing the anaesthetic and analgesic efficacy of caudal levobupivacaine and ropivacaine in paediatric patients

AU - Veeravalli, Sai Tejashree

AU - Sunil, B. V.

AU - Shenoy, T. V.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Introduction: Introduction of S enantiomer of bupivacaine is a major breakthrough in the history of local anaesthesia as the pharmacodynamics of these drugs were favourable in reducing the occurrence of cardiotoxicity, neurotoxicity and unintended motor blockade Aim: To compare efficacy, postoperative analgesia and postoperative motor blockade of 0.25% levobupivacaine with 0.25% ropivacaine in caudal block for children, scheduled for lower abdominal and lowerlimb surgeries. Materials and Methods: 80 children, ASA I–II, 1-10 years, weighing between 5-30 kg, scheduled for elective lower abdominal and lower limb surgeries were given single caudal injection of 1 mL/kg of either levobupivacaine or ropivacaine. Caudal block was given after general anaesthesia using sevoflurane as induction agent airway secured with laryngeal mask. Postoperative pain score was assessed using Children and Infants Postoperative Pain Scale (CHIPPS) scale in children less than 6 years and numerical scale for children more than 6 years. Motor recovery was assessed by modified Bromage scale. Results: Onset of analgesia, duration of analgesia, postoperative pain and motor blockade were comparable between the two groups, of 40 each. Analgesia time was within 5 minutes in both the groups. Duration of analgesia was 404.8±67.6 minutes for levobupivacaine and 413.5±44.4 minutes for ropivacaine, which was not significant statistically. Postoperative analgesia was same between the two groups. It took 120 minutes for complete postoperative motor recovery. The motor recovery between the two groups was statistically not significant at immediate postoperative period (p=0.111), at 60 minutes (p=0.692). Conclusion: We conclude that both 1 mL of 0.25% levobupivacaine and 0.25% ropivacaine provide similar effect caudal anaesthesia and analgesia with motor blockade for 120 minutes.

AB - Introduction: Introduction of S enantiomer of bupivacaine is a major breakthrough in the history of local anaesthesia as the pharmacodynamics of these drugs were favourable in reducing the occurrence of cardiotoxicity, neurotoxicity and unintended motor blockade Aim: To compare efficacy, postoperative analgesia and postoperative motor blockade of 0.25% levobupivacaine with 0.25% ropivacaine in caudal block for children, scheduled for lower abdominal and lowerlimb surgeries. Materials and Methods: 80 children, ASA I–II, 1-10 years, weighing between 5-30 kg, scheduled for elective lower abdominal and lower limb surgeries were given single caudal injection of 1 mL/kg of either levobupivacaine or ropivacaine. Caudal block was given after general anaesthesia using sevoflurane as induction agent airway secured with laryngeal mask. Postoperative pain score was assessed using Children and Infants Postoperative Pain Scale (CHIPPS) scale in children less than 6 years and numerical scale for children more than 6 years. Motor recovery was assessed by modified Bromage scale. Results: Onset of analgesia, duration of analgesia, postoperative pain and motor blockade were comparable between the two groups, of 40 each. Analgesia time was within 5 minutes in both the groups. Duration of analgesia was 404.8±67.6 minutes for levobupivacaine and 413.5±44.4 minutes for ropivacaine, which was not significant statistically. Postoperative analgesia was same between the two groups. It took 120 minutes for complete postoperative motor recovery. The motor recovery between the two groups was statistically not significant at immediate postoperative period (p=0.111), at 60 minutes (p=0.692). Conclusion: We conclude that both 1 mL of 0.25% levobupivacaine and 0.25% ropivacaine provide similar effect caudal anaesthesia and analgesia with motor blockade for 120 minutes.

UR - http://www.scopus.com/inward/record.url?scp=85048285914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048285914&partnerID=8YFLogxK

U2 - 10.7860/JCDR/2018/34700.11652

DO - 10.7860/JCDR/2018/34700.11652

M3 - Article

AN - SCOPUS:85048285914

VL - 12

SP - UC05-UC09

JO - Journal of Clinical and Diagnostic Research

JF - Journal of Clinical and Diagnostic Research

SN - 2249-782X

IS - 6

ER -