Comparison of blood sorbitol level and microalbuminuria in early detection of diabetic nephropathy in type 2 diabetes

B. K. Manjunatha Goud, K. Deepa, O. Sarsina Devi, A. M. Poornima, M. Nandini, Asha Kamath

Research output: Contribution to journalArticle

Abstract

Type 2 DM is a global disease and one of its resultant complication is diabetic nephropathy. An accelerated polyol pathway in diabetes contributes to the development of cataract and nephropathy. Microalbuminuria an early indicator of diabetic nephropathy is an independent risk factor for cardiovascular morbidity and mortality. The main aim of this study was to compare the blood sorbitol levels with microalbuminuria in the early prediction of diabetic nephropathy. The study group included 3 groups of subjects aged between 55-68yrs, Group1-Non diabetic senile cataract patients, Group 2-Diabetic cataract patients without nephropathy, Group3- Diabetic cataract patients with nephropathy. The biochemical parameters estimated included sorbitol, glucose and creatinine in blood; albumin and creatinine in urine. A significant increase in blood sorbitol and glucose along with urine albumin creatinine ratio (UACR) was observed in group 2 and 3. Group 3 showed highly significant increase in blood sorbitol (p<0.01) and UACR (p<0.05) as compared to group 2. Blood sorbitol levels could be used as alternative to MA in the early prediction of diabetic nephropathy.

Original languageEnglish
Article number113
JournalInternational Journal of Pharma and Bio Sciences
Volume1
Issue number4
Publication statusPublished - 2010

Fingerprint

Sorbitol
Diabetic Nephropathies
Medical problems
Type 2 Diabetes Mellitus
Blood
Cataract
Creatinine
Albumins
Urine
Glucose
Blood Glucose
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

@article{fefad95066174727b9e3bdedd869bd93,
title = "Comparison of blood sorbitol level and microalbuminuria in early detection of diabetic nephropathy in type 2 diabetes",
abstract = "Type 2 DM is a global disease and one of its resultant complication is diabetic nephropathy. An accelerated polyol pathway in diabetes contributes to the development of cataract and nephropathy. Microalbuminuria an early indicator of diabetic nephropathy is an independent risk factor for cardiovascular morbidity and mortality. The main aim of this study was to compare the blood sorbitol levels with microalbuminuria in the early prediction of diabetic nephropathy. The study group included 3 groups of subjects aged between 55-68yrs, Group1-Non diabetic senile cataract patients, Group 2-Diabetic cataract patients without nephropathy, Group3- Diabetic cataract patients with nephropathy. The biochemical parameters estimated included sorbitol, glucose and creatinine in blood; albumin and creatinine in urine. A significant increase in blood sorbitol and glucose along with urine albumin creatinine ratio (UACR) was observed in group 2 and 3. Group 3 showed highly significant increase in blood sorbitol (p<0.01) and UACR (p<0.05) as compared to group 2. Blood sorbitol levels could be used as alternative to MA in the early prediction of diabetic nephropathy.",
author = "{Manjunatha Goud}, {B. K.} and K. Deepa and {Sarsina Devi}, O. and Poornima, {A. M.} and M. Nandini and Asha Kamath",
year = "2010",
language = "English",
volume = "1",
journal = "International Journal of Pharma and Bio Sciences",
issn = "0975-6299",
publisher = "International Journal of Pharma and Bio Sciences",
number = "4",

}

Comparison of blood sorbitol level and microalbuminuria in early detection of diabetic nephropathy in type 2 diabetes. / Manjunatha Goud, B. K.; Deepa, K.; Sarsina Devi, O.; Poornima, A. M.; Nandini, M.; Kamath, Asha.

In: International Journal of Pharma and Bio Sciences, Vol. 1, No. 4, 113, 2010.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison of blood sorbitol level and microalbuminuria in early detection of diabetic nephropathy in type 2 diabetes

AU - Manjunatha Goud, B. K.

AU - Deepa, K.

AU - Sarsina Devi, O.

AU - Poornima, A. M.

AU - Nandini, M.

AU - Kamath, Asha

PY - 2010

Y1 - 2010

N2 - Type 2 DM is a global disease and one of its resultant complication is diabetic nephropathy. An accelerated polyol pathway in diabetes contributes to the development of cataract and nephropathy. Microalbuminuria an early indicator of diabetic nephropathy is an independent risk factor for cardiovascular morbidity and mortality. The main aim of this study was to compare the blood sorbitol levels with microalbuminuria in the early prediction of diabetic nephropathy. The study group included 3 groups of subjects aged between 55-68yrs, Group1-Non diabetic senile cataract patients, Group 2-Diabetic cataract patients without nephropathy, Group3- Diabetic cataract patients with nephropathy. The biochemical parameters estimated included sorbitol, glucose and creatinine in blood; albumin and creatinine in urine. A significant increase in blood sorbitol and glucose along with urine albumin creatinine ratio (UACR) was observed in group 2 and 3. Group 3 showed highly significant increase in blood sorbitol (p<0.01) and UACR (p<0.05) as compared to group 2. Blood sorbitol levels could be used as alternative to MA in the early prediction of diabetic nephropathy.

AB - Type 2 DM is a global disease and one of its resultant complication is diabetic nephropathy. An accelerated polyol pathway in diabetes contributes to the development of cataract and nephropathy. Microalbuminuria an early indicator of diabetic nephropathy is an independent risk factor for cardiovascular morbidity and mortality. The main aim of this study was to compare the blood sorbitol levels with microalbuminuria in the early prediction of diabetic nephropathy. The study group included 3 groups of subjects aged between 55-68yrs, Group1-Non diabetic senile cataract patients, Group 2-Diabetic cataract patients without nephropathy, Group3- Diabetic cataract patients with nephropathy. The biochemical parameters estimated included sorbitol, glucose and creatinine in blood; albumin and creatinine in urine. A significant increase in blood sorbitol and glucose along with urine albumin creatinine ratio (UACR) was observed in group 2 and 3. Group 3 showed highly significant increase in blood sorbitol (p<0.01) and UACR (p<0.05) as compared to group 2. Blood sorbitol levels could be used as alternative to MA in the early prediction of diabetic nephropathy.

UR - http://www.scopus.com/inward/record.url?scp=84455201823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84455201823&partnerID=8YFLogxK

M3 - Article

VL - 1

JO - International Journal of Pharma and Bio Sciences

JF - International Journal of Pharma and Bio Sciences

SN - 0975-6299

IS - 4

M1 - 113

ER -