Comparison of Chitosan-lactic Acid-poly vinyl alcohol and Chitosan-hydroxyapatite Composite Membrane as Wound Healing Accelerator

Goutam Thakur, Kunal Pal, Subrata Pal, Smritinath Chakraborty, Arfat Anis

Research output: Contribution to journalArticle

Abstract

Wound healing is a complex biochemical process and may be promoted by moist wound dressings, which helps in maintaining a suitable micro-environment favorable for migration and proliferation of fibroblast cells. Chitosan has been used by many researchers to develop various wound healing products. The current study deals with the development of chitosan-poly (vinyl alcohol) blended membrane and chitosan-hydroxyapatite composite membrane. The membranes were prepared using lactic acid as solvent. The developed membranes were characterized for their mechanical strength hemocompatibility. Membranes demonstrated significantly different mechanical strength and hemocompatibilty. Further, preliminary results indicated that the developed membranes could be tried as wound dressing materials. The afore-mentioned membranes were used as wound dressing materials for the treatment of surgically induced wounds in matured Sprague-Dawley rats. The wound healing results indicated that the healing rate was faster with the chitosan-hydroxyapatite membrane.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalTrends in Biomaterials and Artificial Organs
Volume33
Issue number2
Publication statusPublished - 01-09-2019

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine (miscellaneous)

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