Comparison of efficacy of intrathecal morphine 100μg and 200μg for postoperative pain relief in patients undergoing lower abdominal and lower limb surgeries

Shaila S. Kamath, Pradeep Hosagoudar, Ambareesha

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: This study was designed to compare the efficacy of postoperative analgesia with intrathecal morphine in doses of 100μg, 200 μg with that of patients who received placebo (normal saline). And to compare the advantages vs. side effects between patients receiving 100 μg and 200 μg of intrathecal morphine. Patients & Methods: Sixty patients of ASA grade I and II scheduled for lower abdominal and lower limb surgeries were randomly allocated to receive either 3 ml of 0.5% hyperbaric bupivacaine with 1 ml of 0.9% normal saline (Group I n=20) or 3 ml of 0.5% hyperbaric bupivacaine with 1ml of morphine 100μg (Group II n= 20) or 3 ml of 0.5% hyperbaric bupivacaine with 1ml of morphine 200 μg (Group III n= 20) Results: Patients pulse rate, blood pressure, respiratory rate, spo2, electrocardiogram was monitored through out the procedure and postoperatively till 24 hours. Patients were assessed for pain relief, nausea, vomiting, pruritus, sedation, urinary retention, rescue analgesia and respiratory depression. Administration of morphine intrathecally added to hyperbaric bupivacaine gives excellent postoperative analgesia which is dose dependent. 200 μg of intrathecal morphine provided excellent analgesia up to 36 hours. The incidence of nausea, vomiting and urinary retention were also dose related but with no resultant respiratory depression.

Original languageEnglish
Pages (from-to)63-65
Number of pages3
JournalJournal of Anaesthesiology Clinical Pharmacology
Volume25
Issue number1
Publication statusPublished - 01-01-2009

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Postoperative Pain
Morphine
Lower Extremity
Bupivacaine
Analgesia
Urinary Retention
Respiratory Insufficiency
Nausea
Vomiting
Pruritus
Respiratory Rate
Electrocardiography
Heart Rate
Placebos
Blood Pressure
Pain
Incidence

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)
  • Anesthesiology and Pain Medicine

Cite this

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abstract = "Background: This study was designed to compare the efficacy of postoperative analgesia with intrathecal morphine in doses of 100μg, 200 μg with that of patients who received placebo (normal saline). And to compare the advantages vs. side effects between patients receiving 100 μg and 200 μg of intrathecal morphine. Patients & Methods: Sixty patients of ASA grade I and II scheduled for lower abdominal and lower limb surgeries were randomly allocated to receive either 3 ml of 0.5{\%} hyperbaric bupivacaine with 1 ml of 0.9{\%} normal saline (Group I n=20) or 3 ml of 0.5{\%} hyperbaric bupivacaine with 1ml of morphine 100μg (Group II n= 20) or 3 ml of 0.5{\%} hyperbaric bupivacaine with 1ml of morphine 200 μg (Group III n= 20) Results: Patients pulse rate, blood pressure, respiratory rate, spo2, electrocardiogram was monitored through out the procedure and postoperatively till 24 hours. Patients were assessed for pain relief, nausea, vomiting, pruritus, sedation, urinary retention, rescue analgesia and respiratory depression. Administration of morphine intrathecally added to hyperbaric bupivacaine gives excellent postoperative analgesia which is dose dependent. 200 μg of intrathecal morphine provided excellent analgesia up to 36 hours. The incidence of nausea, vomiting and urinary retention were also dose related but with no resultant respiratory depression.",
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Comparison of efficacy of intrathecal morphine 100μg and 200μg for postoperative pain relief in patients undergoing lower abdominal and lower limb surgeries. / Kamath, Shaila S.; Hosagoudar, Pradeep; Ambareesha.

In: Journal of Anaesthesiology Clinical Pharmacology, Vol. 25, No. 1, 01.01.2009, p. 63-65.

Research output: Contribution to journalArticle

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