Comparison of isotope dilution and a portable anodic stripping voltammetry device for blood lead measurements: Source of lead in blood of female adults from Bangalore

Brian L. Gulson, Thuppil Venkatesh, Jacqueline Palmer, Herman Suil D'Souza, Michael Korsch

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have analyzed blood samples from 20 pregnant Indian women from the city of Bangalore to assess the suitability of Indian subjects in a pregnancy study and assess the feasibility of using the lead isotopic method for determining sources and pathways of lead in Indian subjects. Blood lead concentrations range from 4.3 to 20.1 μg dL-1 with a geometric mean of 9.0 μg dL-1. There is excellent agreement between the isotope dilution measurements for blood lead concentration and those obtained by anodic stripping voltammetry (ASV; R2 0.96, P < 0.0001). A paired t-test shows that there is a statistically significant difference (p 0.008) with the results for ASV being approximately 6% higher than for those obtained by isotope dilution. The 206pb/204pb ratios range from 17.12 to 17.75 and showed major differences to the lead isotopic ratios that have been measured in Indian lead-zinc mineral deposits. It is suggested that lead in petrol is a major source of lead in the blood of Bangalore women.

Original languageEnglish
Pages (from-to)979-982
Number of pages4
JournalAustralian Journal of Chemistry
Volume57
Issue number10
DOIs
Publication statusPublished - 2004

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Voltammetry
Isotopes
Dilution
Blood
Mineral resources
Zinc
Lead

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

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title = "Comparison of isotope dilution and a portable anodic stripping voltammetry device for blood lead measurements: Source of lead in blood of female adults from Bangalore",
abstract = "We have analyzed blood samples from 20 pregnant Indian women from the city of Bangalore to assess the suitability of Indian subjects in a pregnancy study and assess the feasibility of using the lead isotopic method for determining sources and pathways of lead in Indian subjects. Blood lead concentrations range from 4.3 to 20.1 μg dL-1 with a geometric mean of 9.0 μg dL-1. There is excellent agreement between the isotope dilution measurements for blood lead concentration and those obtained by anodic stripping voltammetry (ASV; R2 0.96, P < 0.0001). A paired t-test shows that there is a statistically significant difference (p 0.008) with the results for ASV being approximately 6{\%} higher than for those obtained by isotope dilution. The 206pb/204pb ratios range from 17.12 to 17.75 and showed major differences to the lead isotopic ratios that have been measured in Indian lead-zinc mineral deposits. It is suggested that lead in petrol is a major source of lead in the blood of Bangalore women.",
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Comparison of isotope dilution and a portable anodic stripping voltammetry device for blood lead measurements : Source of lead in blood of female adults from Bangalore. / Gulson, Brian L.; Venkatesh, Thuppil; Palmer, Jacqueline; D'Souza, Herman Suil; Korsch, Michael.

In: Australian Journal of Chemistry, Vol. 57, No. 10, 2004, p. 979-982.

Research output: Contribution to journalArticle

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