Comparison of polymorphonuclear leukocyte functions in oral carcinoma patients and healthy controls

K. P. Nandita, Karen Boaz, Ethel Suman, Ashwini Hegde, C. P. Mahesh

Research output: Contribution to journalArticle

Abstract

To compare the phagocytic activity and intracellular killing activity of Polymorphonuclear Leukocytes in peripheral blood of patients with Oral Squamous Cell Carcinoma and healthy controls.Study comprised of thirty patients with histologically proven squamous cell carcinoma of the oral cavity and ten controls that were age - and sex - matched healthy non - hospitalized patients that included five smokers and five non - smokers. Phagocytosis and intracellular killing activity were assayed.Student's t- test (SPSS version 11.0) and Annova were used to compare the healthy patients and oral carcinoma patients.Present study demonstrated suppression in both phagocytic as well as intracellular killing activity of PMNs in patients with oral squamous cell carcinoma, when compared to that of healthy controls.A significant suppression of both phagocytosis and intracellular killing of candidal species by neutrophils was observed in the patients with Oral cancer. The relatively low candidacidal activity of neutrophils is suggestive of cellular immunosuppression which is often induced in various malignancies.

Original languageEnglish
Pages (from-to)857-864
Number of pages8
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume4
Issue number1
Publication statusPublished - 01-01-2013

Fingerprint

Neutrophils
Carcinoma
Squamous Cell Carcinoma
Phagocytosis
Blood
Students
Mouth Neoplasms
Epithelial Cells
Immunosuppression
Mouth
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{d73503e79f5c4135ac9da16bf8be833c,
title = "Comparison of polymorphonuclear leukocyte functions in oral carcinoma patients and healthy controls",
abstract = "To compare the phagocytic activity and intracellular killing activity of Polymorphonuclear Leukocytes in peripheral blood of patients with Oral Squamous Cell Carcinoma and healthy controls.Study comprised of thirty patients with histologically proven squamous cell carcinoma of the oral cavity and ten controls that were age - and sex - matched healthy non - hospitalized patients that included five smokers and five non - smokers. Phagocytosis and intracellular killing activity were assayed.Student's t- test (SPSS version 11.0) and Annova were used to compare the healthy patients and oral carcinoma patients.Present study demonstrated suppression in both phagocytic as well as intracellular killing activity of PMNs in patients with oral squamous cell carcinoma, when compared to that of healthy controls.A significant suppression of both phagocytosis and intracellular killing of candidal species by neutrophils was observed in the patients with Oral cancer. The relatively low candidacidal activity of neutrophils is suggestive of cellular immunosuppression which is often induced in various malignancies.",
author = "Nandita, {K. P.} and Karen Boaz and Ethel Suman and Ashwini Hegde and Mahesh, {C. P.}",
year = "2013",
month = "1",
day = "1",
language = "English",
volume = "4",
pages = "857--864",
journal = "Research Journal of Pharmaceutical, Biological and Chemical Sciences",
issn = "0975-8585",
publisher = "RJPBCS",
number = "1",

}

TY - JOUR

T1 - Comparison of polymorphonuclear leukocyte functions in oral carcinoma patients and healthy controls

AU - Nandita, K. P.

AU - Boaz, Karen

AU - Suman, Ethel

AU - Hegde, Ashwini

AU - Mahesh, C. P.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - To compare the phagocytic activity and intracellular killing activity of Polymorphonuclear Leukocytes in peripheral blood of patients with Oral Squamous Cell Carcinoma and healthy controls.Study comprised of thirty patients with histologically proven squamous cell carcinoma of the oral cavity and ten controls that were age - and sex - matched healthy non - hospitalized patients that included five smokers and five non - smokers. Phagocytosis and intracellular killing activity were assayed.Student's t- test (SPSS version 11.0) and Annova were used to compare the healthy patients and oral carcinoma patients.Present study demonstrated suppression in both phagocytic as well as intracellular killing activity of PMNs in patients with oral squamous cell carcinoma, when compared to that of healthy controls.A significant suppression of both phagocytosis and intracellular killing of candidal species by neutrophils was observed in the patients with Oral cancer. The relatively low candidacidal activity of neutrophils is suggestive of cellular immunosuppression which is often induced in various malignancies.

AB - To compare the phagocytic activity and intracellular killing activity of Polymorphonuclear Leukocytes in peripheral blood of patients with Oral Squamous Cell Carcinoma and healthy controls.Study comprised of thirty patients with histologically proven squamous cell carcinoma of the oral cavity and ten controls that were age - and sex - matched healthy non - hospitalized patients that included five smokers and five non - smokers. Phagocytosis and intracellular killing activity were assayed.Student's t- test (SPSS version 11.0) and Annova were used to compare the healthy patients and oral carcinoma patients.Present study demonstrated suppression in both phagocytic as well as intracellular killing activity of PMNs in patients with oral squamous cell carcinoma, when compared to that of healthy controls.A significant suppression of both phagocytosis and intracellular killing of candidal species by neutrophils was observed in the patients with Oral cancer. The relatively low candidacidal activity of neutrophils is suggestive of cellular immunosuppression which is often induced in various malignancies.

UR - http://www.scopus.com/inward/record.url?scp=84874719788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874719788&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84874719788

VL - 4

SP - 857

EP - 864

JO - Research Journal of Pharmaceutical, Biological and Chemical Sciences

JF - Research Journal of Pharmaceutical, Biological and Chemical Sciences

SN - 0975-8585

IS - 1

ER -