Comparison of propofol ketamine versus propofol fentanyl as combination for total intravenous anesthesia on short gynecological procedures

Kritagya Shukla, Shaila S. Kamath

Research output: Contribution to journalReview article

Abstract

Background: Use of propofol-based total intravenous anesthesia (TIVA) has increased in the past two decades due to better understanding of pharmacokinetics of intravenous anesthetic drugs. TIVA can be used as an alternative to inhalational anesthesia in minor gynecological procedures. Advantages of TIVA with propofol also include reduced nausea and vomiting, reduced atmospheric pollution, and a better wake up profile. The study objective was to compare two drug regimens: propofol-ketamine and propofol-fentanyl. Also, induction, maintenance and post-extubation parameters were evaluated. Materials & Methods: This study was a prospective randomized, single blinded study involving 72 adult patients ranging from 18 to 60 years, belonging to ASA grade 1 or 2 undergoing short gynecological procedures, were assigned into two groups. Propofol-ketamine was administered to group 1 while propofol-fentanyl was administered to group 2. All the results were analyzed statistically using student's t-test, chi-square test and Fisher’s exact test. Results: In group 1 rescue boluses of propofol was in the mean of 29.38 mgs and in group 2 was in the mean of 21.33mgs which was statistically significant with a p-value of 0.009. Mean emergence time in group1 was 5.94 minutes whereas in group 2 was 4.89 minutes which was statistically significant with a p-value of 0.001. The mean recovery time in group 1 was 11.25 minutes whereas in group 2 was 9.17 minutes which was statistically significant with a p-value of 0.001. Conclusions: Propofol-fentanyl combinations showed better emergence time and recovery profile.

Original languageEnglish
Pages (from-to)1591-1596
Number of pages6
JournalInternational Journal of Pharmaceutical Research
Volume12
DOIs
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

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