Comparison of serum levels of fructosamine and erythrocyte sodium potassium ATPase (Na+/K+ ATPase) in gestational diabetes mellitus (GDM) and non-gestational diabetes mellitus (non GDM) patients

Revathi Panduranga Shenoy, Gagana Hanumaiah, Varashree Bolar Suryakanth, Priyanka Shridharan

Research output: Contribution to journalArticle

Abstract

Background: The study aims at the comparison and correlation of serum levels of fructosamine and erythrocyte Na+/ K+ ATPase in Gestational diabetes mellitus (GDM) and Non Gestational Diabetes Mellitus (Non GDM). Methods: A total of 326 samples were divided into 4 groups. Pregnant women between the age group of 20- 40 years who gave samples for Oral Glucose Tolerance Test (OGTT) were included as the subjects. Anonymized and left over fasting and 2 hours' samples were collected from biochemistry laboratory, Kasturba Hospital, Manipal. Results: In the comparison of fructosamine levels in GDM and Non GDM, fructosamine was found to be significant (p value<0.001) in both fasting and 2 hours (G2) blood glucose condition. Na+/ K+ ATPase did not show any significant variation between the groups. Correlation was not significant between the parameters. Conclusions: Fructosamine showed significant increase when compared between the groups, whereas significant correlation is not obtained between the parameters. Thus, the use fructosamine as a diagnosis tool becomes inconclusive. Further studies must be carried out to identify a marker which reduces the interferences observed in fructosamine and to find out the exact relationship between hyperglycaemia and Na+/ K+ ATPase activity.

Original languageEnglish
Pages (from-to)260-266
Number of pages7
JournalReports of Biochemistry and Molecular Biology
Volume8
Issue number3
Publication statusPublished - 01-01-2019

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Fructosamine
Sodium-Potassium-Exchanging ATPase
Gestational Diabetes
Medical problems
Adenosine Triphosphatases
Diabetes Mellitus
Erythrocytes
Serum
Fasting
Hospital Laboratories
Biochemistry
Glucose Tolerance Test
Hyperglycemia
Blood Glucose
sodium-translocating ATPase
Pregnant Women
Age Groups
Glucose

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biochemistry
  • Molecular Biology
  • Biochemistry, medical

Cite this

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title = "Comparison of serum levels of fructosamine and erythrocyte sodium potassium ATPase (Na+/K+ ATPase) in gestational diabetes mellitus (GDM) and non-gestational diabetes mellitus (non GDM) patients",
abstract = "Background: The study aims at the comparison and correlation of serum levels of fructosamine and erythrocyte Na+/ K+ ATPase in Gestational diabetes mellitus (GDM) and Non Gestational Diabetes Mellitus (Non GDM). Methods: A total of 326 samples were divided into 4 groups. Pregnant women between the age group of 20- 40 years who gave samples for Oral Glucose Tolerance Test (OGTT) were included as the subjects. Anonymized and left over fasting and 2 hours' samples were collected from biochemistry laboratory, Kasturba Hospital, Manipal. Results: In the comparison of fructosamine levels in GDM and Non GDM, fructosamine was found to be significant (p value<0.001) in both fasting and 2 hours (G2) blood glucose condition. Na+/ K+ ATPase did not show any significant variation between the groups. Correlation was not significant between the parameters. Conclusions: Fructosamine showed significant increase when compared between the groups, whereas significant correlation is not obtained between the parameters. Thus, the use fructosamine as a diagnosis tool becomes inconclusive. Further studies must be carried out to identify a marker which reduces the interferences observed in fructosamine and to find out the exact relationship between hyperglycaemia and Na+/ K+ ATPase activity.",
author = "Shenoy, {Revathi Panduranga} and Gagana Hanumaiah and Suryakanth, {Varashree Bolar} and Priyanka Shridharan",
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T1 - Comparison of serum levels of fructosamine and erythrocyte sodium potassium ATPase (Na+/K+ ATPase) in gestational diabetes mellitus (GDM) and non-gestational diabetes mellitus (non GDM) patients

AU - Shenoy, Revathi Panduranga

AU - Hanumaiah, Gagana

AU - Suryakanth, Varashree Bolar

AU - Shridharan, Priyanka

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: The study aims at the comparison and correlation of serum levels of fructosamine and erythrocyte Na+/ K+ ATPase in Gestational diabetes mellitus (GDM) and Non Gestational Diabetes Mellitus (Non GDM). Methods: A total of 326 samples were divided into 4 groups. Pregnant women between the age group of 20- 40 years who gave samples for Oral Glucose Tolerance Test (OGTT) were included as the subjects. Anonymized and left over fasting and 2 hours' samples were collected from biochemistry laboratory, Kasturba Hospital, Manipal. Results: In the comparison of fructosamine levels in GDM and Non GDM, fructosamine was found to be significant (p value<0.001) in both fasting and 2 hours (G2) blood glucose condition. Na+/ K+ ATPase did not show any significant variation between the groups. Correlation was not significant between the parameters. Conclusions: Fructosamine showed significant increase when compared between the groups, whereas significant correlation is not obtained between the parameters. Thus, the use fructosamine as a diagnosis tool becomes inconclusive. Further studies must be carried out to identify a marker which reduces the interferences observed in fructosamine and to find out the exact relationship between hyperglycaemia and Na+/ K+ ATPase activity.

AB - Background: The study aims at the comparison and correlation of serum levels of fructosamine and erythrocyte Na+/ K+ ATPase in Gestational diabetes mellitus (GDM) and Non Gestational Diabetes Mellitus (Non GDM). Methods: A total of 326 samples were divided into 4 groups. Pregnant women between the age group of 20- 40 years who gave samples for Oral Glucose Tolerance Test (OGTT) were included as the subjects. Anonymized and left over fasting and 2 hours' samples were collected from biochemistry laboratory, Kasturba Hospital, Manipal. Results: In the comparison of fructosamine levels in GDM and Non GDM, fructosamine was found to be significant (p value<0.001) in both fasting and 2 hours (G2) blood glucose condition. Na+/ K+ ATPase did not show any significant variation between the groups. Correlation was not significant between the parameters. Conclusions: Fructosamine showed significant increase when compared between the groups, whereas significant correlation is not obtained between the parameters. Thus, the use fructosamine as a diagnosis tool becomes inconclusive. Further studies must be carried out to identify a marker which reduces the interferences observed in fructosamine and to find out the exact relationship between hyperglycaemia and Na+/ K+ ATPase activity.

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