Comparison prophylactic glycopyrrolate, dexamethasone, metoclopramide in control of nausea and vomiting after spinal anaesthesia for caesarean delivery

Gautam Malhotra, Y. V. Suresh, Y. Anupama Suresh, Shaik Gulam Osmani, Kavya Prabhu

Research output: Contribution to journalArticle

Abstract

Background: The effects of spinal anesthesia on women in their labour period are different from those observed in non-obstetric patients. The distribution of the anaesthetic drug in cerebrospinal fluid (CSF) is less predictable than non-obstetric patients, Moreover side effects including hypotension, nausea and vomiting are more common. Aims: To compare the efficacy of inj glyocopyrolate 0.2 mg iv, inj dexamethasone 8mg i.v, inj Metoclorpromide 10mg i.v in control of post-operative nausea and vomiting after spinal anaesthesia for caesarean delivery Method and Material: All consenting women were explained and women were randomly allocated in to four groups of 20 each, Group A inj.Glycopyrrolate 0.2 mg, Group B, inj. Dexamethasone 8 mg, Group C inj. Metoclopramide 10 mg and Group D (n=20) inj. Normal saline 2m1. Level of spinal block, hemodynemic changes, incidence of intraoperative and post-operative nausea and vomiting were noted in all four groups. The incidences of nausea and vomiting were compared in different groups and the differences were tested for significance by calculating ‘z’ value. A ‘p’ value <0.05 was considered significant. Results: The overall (intraoperative & postoperative) incidence of nausea and vomiting which was 20% in group A, 35% in group B, 50% in group C and 60% in group D. Statistical analysis showed that the all three drugs decrease incidence of nausea and vomiting, but glycopyrrolte found to be more effective in preventing nausea and vomiting. Conclusion: The incidences of nausea and vomiting were high fallowing spinal anesthesia during caesarean delivery. Administration of glycopyrrolate intravenously before spinal in caesarean section effectively control the incidence and severity of intraoperative and early postoperative nausea and vomiting compared to the non-treatment group.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalIndian Journal of Public Health Research and Development
Volume10
Issue number7
DOIs
Publication statusPublished - 01-07-2019

Fingerprint

Glycopyrrolate
Metoclopramide
Spinal Anesthesia
Nausea
Dexamethasone
Vomiting
Incidence
Postoperative Nausea and Vomiting
Cesarean Section
Hypotension
Cerebrospinal Fluid
Anesthetics

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Malhotra, Gautam ; Suresh, Y. V. ; Anupama Suresh, Y. ; Osmani, Shaik Gulam ; Prabhu, Kavya. / Comparison prophylactic glycopyrrolate, dexamethasone, metoclopramide in control of nausea and vomiting after spinal anaesthesia for caesarean delivery. In: Indian Journal of Public Health Research and Development. 2019 ; Vol. 10, No. 7. pp. 261-266.
@article{d370ddee8d3844259214b2cf86e25715,
title = "Comparison prophylactic glycopyrrolate, dexamethasone, metoclopramide in control of nausea and vomiting after spinal anaesthesia for caesarean delivery",
abstract = "Background: The effects of spinal anesthesia on women in their labour period are different from those observed in non-obstetric patients. The distribution of the anaesthetic drug in cerebrospinal fluid (CSF) is less predictable than non-obstetric patients, Moreover side effects including hypotension, nausea and vomiting are more common. Aims: To compare the efficacy of inj glyocopyrolate 0.2 mg iv, inj dexamethasone 8mg i.v, inj Metoclorpromide 10mg i.v in control of post-operative nausea and vomiting after spinal anaesthesia for caesarean delivery Method and Material: All consenting women were explained and women were randomly allocated in to four groups of 20 each, Group A inj.Glycopyrrolate 0.2 mg, Group B, inj. Dexamethasone 8 mg, Group C inj. Metoclopramide 10 mg and Group D (n=20) inj. Normal saline 2m1. Level of spinal block, hemodynemic changes, incidence of intraoperative and post-operative nausea and vomiting were noted in all four groups. The incidences of nausea and vomiting were compared in different groups and the differences were tested for significance by calculating ‘z’ value. A ‘p’ value <0.05 was considered significant. Results: The overall (intraoperative & postoperative) incidence of nausea and vomiting which was 20{\%} in group A, 35{\%} in group B, 50{\%} in group C and 60{\%} in group D. Statistical analysis showed that the all three drugs decrease incidence of nausea and vomiting, but glycopyrrolte found to be more effective in preventing nausea and vomiting. Conclusion: The incidences of nausea and vomiting were high fallowing spinal anesthesia during caesarean delivery. Administration of glycopyrrolate intravenously before spinal in caesarean section effectively control the incidence and severity of intraoperative and early postoperative nausea and vomiting compared to the non-treatment group.",
author = "Gautam Malhotra and Suresh, {Y. V.} and {Anupama Suresh}, Y. and Osmani, {Shaik Gulam} and Kavya Prabhu",
year = "2019",
month = "7",
day = "1",
doi = "10.5958/0976-5506.2019.01574.2",
language = "English",
volume = "10",
pages = "261--266",
journal = "Indian Journal of Public Health Research and Development",
issn = "0976-0245",
publisher = "R.K. Sharma, Institute of Medico-Legal Publications",
number = "7",

}

Comparison prophylactic glycopyrrolate, dexamethasone, metoclopramide in control of nausea and vomiting after spinal anaesthesia for caesarean delivery. / Malhotra, Gautam; Suresh, Y. V.; Anupama Suresh, Y.; Osmani, Shaik Gulam; Prabhu, Kavya.

In: Indian Journal of Public Health Research and Development, Vol. 10, No. 7, 01.07.2019, p. 261-266.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Comparison prophylactic glycopyrrolate, dexamethasone, metoclopramide in control of nausea and vomiting after spinal anaesthesia for caesarean delivery

AU - Malhotra, Gautam

AU - Suresh, Y. V.

AU - Anupama Suresh, Y.

AU - Osmani, Shaik Gulam

AU - Prabhu, Kavya

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: The effects of spinal anesthesia on women in their labour period are different from those observed in non-obstetric patients. The distribution of the anaesthetic drug in cerebrospinal fluid (CSF) is less predictable than non-obstetric patients, Moreover side effects including hypotension, nausea and vomiting are more common. Aims: To compare the efficacy of inj glyocopyrolate 0.2 mg iv, inj dexamethasone 8mg i.v, inj Metoclorpromide 10mg i.v in control of post-operative nausea and vomiting after spinal anaesthesia for caesarean delivery Method and Material: All consenting women were explained and women were randomly allocated in to four groups of 20 each, Group A inj.Glycopyrrolate 0.2 mg, Group B, inj. Dexamethasone 8 mg, Group C inj. Metoclopramide 10 mg and Group D (n=20) inj. Normal saline 2m1. Level of spinal block, hemodynemic changes, incidence of intraoperative and post-operative nausea and vomiting were noted in all four groups. The incidences of nausea and vomiting were compared in different groups and the differences were tested for significance by calculating ‘z’ value. A ‘p’ value <0.05 was considered significant. Results: The overall (intraoperative & postoperative) incidence of nausea and vomiting which was 20% in group A, 35% in group B, 50% in group C and 60% in group D. Statistical analysis showed that the all three drugs decrease incidence of nausea and vomiting, but glycopyrrolte found to be more effective in preventing nausea and vomiting. Conclusion: The incidences of nausea and vomiting were high fallowing spinal anesthesia during caesarean delivery. Administration of glycopyrrolate intravenously before spinal in caesarean section effectively control the incidence and severity of intraoperative and early postoperative nausea and vomiting compared to the non-treatment group.

AB - Background: The effects of spinal anesthesia on women in their labour period are different from those observed in non-obstetric patients. The distribution of the anaesthetic drug in cerebrospinal fluid (CSF) is less predictable than non-obstetric patients, Moreover side effects including hypotension, nausea and vomiting are more common. Aims: To compare the efficacy of inj glyocopyrolate 0.2 mg iv, inj dexamethasone 8mg i.v, inj Metoclorpromide 10mg i.v in control of post-operative nausea and vomiting after spinal anaesthesia for caesarean delivery Method and Material: All consenting women were explained and women were randomly allocated in to four groups of 20 each, Group A inj.Glycopyrrolate 0.2 mg, Group B, inj. Dexamethasone 8 mg, Group C inj. Metoclopramide 10 mg and Group D (n=20) inj. Normal saline 2m1. Level of spinal block, hemodynemic changes, incidence of intraoperative and post-operative nausea and vomiting were noted in all four groups. The incidences of nausea and vomiting were compared in different groups and the differences were tested for significance by calculating ‘z’ value. A ‘p’ value <0.05 was considered significant. Results: The overall (intraoperative & postoperative) incidence of nausea and vomiting which was 20% in group A, 35% in group B, 50% in group C and 60% in group D. Statistical analysis showed that the all three drugs decrease incidence of nausea and vomiting, but glycopyrrolte found to be more effective in preventing nausea and vomiting. Conclusion: The incidences of nausea and vomiting were high fallowing spinal anesthesia during caesarean delivery. Administration of glycopyrrolate intravenously before spinal in caesarean section effectively control the incidence and severity of intraoperative and early postoperative nausea and vomiting compared to the non-treatment group.

UR - http://www.scopus.com/inward/record.url?scp=85073775591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073775591&partnerID=8YFLogxK

U2 - 10.5958/0976-5506.2019.01574.2

DO - 10.5958/0976-5506.2019.01574.2

M3 - Article

AN - SCOPUS:85073775591

VL - 10

SP - 261

EP - 266

JO - Indian Journal of Public Health Research and Development

JF - Indian Journal of Public Health Research and Development

SN - 0976-0245

IS - 7

ER -