Complications and management in Descemet′s stripping endothelial keratoplasty

Analysis of consecutive 430 cases

Samar K. Basak, Soham Basak

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To analyze the complications and their managements in Descemet′s stripping endothelial keratoplasty (DSEK) in consecutive 430 cases by single surgeon in a tertiary eye hospital. Materials and Methods: 430 eyes of 366 patients with endothelial dysfunctions scheduled for DSEK, were analyzed retrospectively. In all cases donor dissection was performed manually, and ′Taco′ insertion and unfolding technique was used. Intra-operative and postoperative complications with their managements and outcomes were reviewed retrospectively. Periodic endothelial cell density was analyzed for each patient till the last visit. Follow-up period was between 3 to 60 months (mean 18.7 months). Results: 13 (3.0%) eyes had operative complications during donor dissection and 16 (3.7%) had during recipient procedure. In 7 (1.6%) eyes, donor lenticule was replaced with a new one during the surgery. In early postoperative period, 21 (4.9%) eyes had donor dislocation and 12 (2.8%) eyes had air-induced pupillary block; and they were managed immediately. 2 cases had primary graft failure and in 1 case had postoperative bacterial endophthalmitis requiring evisceration. In late postoperative period, 48 (11.3%) eyes had secondary glaucoma and 14 (3.3%) eyes had late secondary graft failure. Endothelial rejection occurred in 5 (1.2%) cases. Mean endothelial cell loss was 19.7% after 3 months and 54.2% after 5 years. Total graft failure in this series was 31 (7.2%) and in 17 cases re-DSEK was performed successfully. Conclusions: Both operative and postoperative complications do occur in DSEK. Most of these complications can be managed by medical or appropriate surgical means. Some of the complications can be avoided and reduced with experience.

Original languageEnglish
Pages (from-to)209-218
Number of pages10
JournalIndian Journal of Ophthalmology
Volume62
Issue number2
DOIs
Publication statusPublished - 01-02-2014
Externally publishedYes

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Descemet Stripping Endothelial Keratoplasty
Tissue Donors
Transplants
Postoperative Period
Dissection
Endothelial Cells
Endophthalmitis
Tertiary Care Centers
Glaucoma
Cell Count
Air

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

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title = "Complications and management in Descemet′s stripping endothelial keratoplasty: Analysis of consecutive 430 cases",
abstract = "Purpose: To analyze the complications and their managements in Descemet′s stripping endothelial keratoplasty (DSEK) in consecutive 430 cases by single surgeon in a tertiary eye hospital. Materials and Methods: 430 eyes of 366 patients with endothelial dysfunctions scheduled for DSEK, were analyzed retrospectively. In all cases donor dissection was performed manually, and ′Taco′ insertion and unfolding technique was used. Intra-operative and postoperative complications with their managements and outcomes were reviewed retrospectively. Periodic endothelial cell density was analyzed for each patient till the last visit. Follow-up period was between 3 to 60 months (mean 18.7 months). Results: 13 (3.0{\%}) eyes had operative complications during donor dissection and 16 (3.7{\%}) had during recipient procedure. In 7 (1.6{\%}) eyes, donor lenticule was replaced with a new one during the surgery. In early postoperative period, 21 (4.9{\%}) eyes had donor dislocation and 12 (2.8{\%}) eyes had air-induced pupillary block; and they were managed immediately. 2 cases had primary graft failure and in 1 case had postoperative bacterial endophthalmitis requiring evisceration. In late postoperative period, 48 (11.3{\%}) eyes had secondary glaucoma and 14 (3.3{\%}) eyes had late secondary graft failure. Endothelial rejection occurred in 5 (1.2{\%}) cases. Mean endothelial cell loss was 19.7{\%} after 3 months and 54.2{\%} after 5 years. Total graft failure in this series was 31 (7.2{\%}) and in 17 cases re-DSEK was performed successfully. Conclusions: Both operative and postoperative complications do occur in DSEK. Most of these complications can be managed by medical or appropriate surgical means. Some of the complications can be avoided and reduced with experience.",
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Complications and management in Descemet′s stripping endothelial keratoplasty : Analysis of consecutive 430 cases. / Basak, Samar K.; Basak, Soham.

In: Indian Journal of Ophthalmology, Vol. 62, No. 2, 01.02.2014, p. 209-218.

Research output: Contribution to journalArticle

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