Concise review: Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells

Malini Visweswaran, Frank Arfuso, Sudha Warrier, Arun Dharmarajan

Research output: Contribution to journalArticle

Abstract

Emerging evidences in cancer metabolomics have identified reprogrammed metabolic pathways to be a major hallmark of cancer, among which deregulated lipid metabolism is a prominent field receiving increasing attention. Cancer stem cells (CSCs) comprise <0.1% of the tumor bulk and possess high self-renewal, tumor initiating properties, and are responsible for therapeutic resistance, disease recurrence, and tumor metastasis. Hence, it is imperative to understand the metabolic rewiring occurring in CSCs, especially their lipid metabolism, on which there have been recent reports. CSCs rely highly upon lipid metabolism for maintaining their stemness properties and fulfilling their biomass and energy demands, ultimately leading to cancer growth and invasion. Hence, in this review we will shed light on the aberrant lipid metabolism that CSCs exploit to boost their survival, which comprises upregulation in de novo lipogenesis, lipid droplet synthesis, lipid desaturation, and β-oxidation. Furthermore, the metabolic regulators involved in the process, such as key lipogenic enzymes, are also highlighted. Finally, we also summarize the therapeutic strategies targeting the key regulators involved in CSCs' lipid metabolism, which thereby demonstrates the potential to develop powerful and novel therapeutics against the CSC lipid metabolome. Stem Cells 2019.

Original languageEnglish
JournalStem Cells
DOIs
Publication statusAccepted/In press - 01-01-2019

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Neoplastic Stem Cells
Lipid Metabolism
Neoplasms
Therapeutics
Lipids
Lipogenesis
Disease Resistance
Metabolomics
Metabolome
Metabolic Networks and Pathways
Biomass
Up-Regulation
Stem Cells
Neoplasm Metastasis
Recurrence
Enzymes
Growth

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

Cite this

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Concise review : Aberrant lipid metabolism as an emerging therapeutic strategy to target cancer stem cells. / Visweswaran, Malini; Arfuso, Frank; Warrier, Sudha; Dharmarajan, Arun.

In: Stem Cells, 01.01.2019.

Research output: Contribution to journalArticle

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