Consistency of fractional anisotropy values using different combinations of B-value and time of echo (TE) in diffusion tensor imaging of normal brain white matter

Rahul P. Kotian, K. Prakashini, Sreekumaran Nair, M. Satish Babu

Research output: Contribution to journalArticle

Abstract

Introduction: Fractional Anisotropy (FA) values are considered as a solid concrete index for determining white matter integrity in ageing and neurodegenerative diseases. FA is more comparable and reliable parameter than individual diffusivity parameters. A b-value and Time of Echo (TE) significantly affect the reproducibility and accuracy of Diffusion Tensor Imaging (DTI) derived indices at 1.5 Tesla (T) MRI machines in grey and white matter. Hence, no fixed b-value and TE protocol combination is recommended in literature to obtain consistent FA values, as it is a relatively new imaging technique. Aim: To check the consistency of FA values using different combinations of b-value and TE in DTI of normal brain white matter and to establish a standardised protocol for calculating FA values in different regions of normal brain white matter of the corpus callosum, centrum semiovale and pons. Materials and Methods: A cross-sectional study of 23 healthy participants without neurological abnormalities using 1.5 T MRI, DTI of brain white matter was performed. FA values were measured at the corpus callosum, centrum semiovale and pons using fiber track analysis in six different combinations of b-value and TE. Results: The FA values with least coefficient of variation was found with a b-value of 1000 s/mm2 and TE 100 ms. Conclusion: The current study established a standardised protocol for calculating FA values in different regions of normal brain white matter of the corpus callosum, centrum semiovale and pons.

Original languageEnglish
Pages (from-to)TC01-TC04
JournalJournal of Clinical and Diagnostic Research
Volume12
Issue number12
DOIs
Publication statusPublished - 01-12-2018

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Diffusion tensor imaging
Diffusion Tensor Imaging
Anisotropy
Brain
Pons
Corpus Callosum
Magnetic resonance imaging
Neurodegenerative diseases
White Matter
Neurodegenerative Diseases
Healthy Volunteers
Cross-Sectional Studies
Aging of materials
Concretes
Imaging techniques
Fibers

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

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title = "Consistency of fractional anisotropy values using different combinations of B-value and time of echo (TE) in diffusion tensor imaging of normal brain white matter",
abstract = "Introduction: Fractional Anisotropy (FA) values are considered as a solid concrete index for determining white matter integrity in ageing and neurodegenerative diseases. FA is more comparable and reliable parameter than individual diffusivity parameters. A b-value and Time of Echo (TE) significantly affect the reproducibility and accuracy of Diffusion Tensor Imaging (DTI) derived indices at 1.5 Tesla (T) MRI machines in grey and white matter. Hence, no fixed b-value and TE protocol combination is recommended in literature to obtain consistent FA values, as it is a relatively new imaging technique. Aim: To check the consistency of FA values using different combinations of b-value and TE in DTI of normal brain white matter and to establish a standardised protocol for calculating FA values in different regions of normal brain white matter of the corpus callosum, centrum semiovale and pons. Materials and Methods: A cross-sectional study of 23 healthy participants without neurological abnormalities using 1.5 T MRI, DTI of brain white matter was performed. FA values were measured at the corpus callosum, centrum semiovale and pons using fiber track analysis in six different combinations of b-value and TE. Results: The FA values with least coefficient of variation was found with a b-value of 1000 s/mm2 and TE 100 ms. Conclusion: The current study established a standardised protocol for calculating FA values in different regions of normal brain white matter of the corpus callosum, centrum semiovale and pons.",
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Consistency of fractional anisotropy values using different combinations of B-value and time of echo (TE) in diffusion tensor imaging of normal brain white matter. / Kotian, Rahul P.; Prakashini, K.; Nair, Sreekumaran; Satish Babu, M.

In: Journal of Clinical and Diagnostic Research, Vol. 12, No. 12, 01.12.2018, p. TC01-TC04.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Consistency of fractional anisotropy values using different combinations of B-value and time of echo (TE) in diffusion tensor imaging of normal brain white matter

AU - Kotian, Rahul P.

AU - Prakashini, K.

AU - Nair, Sreekumaran

AU - Satish Babu, M.

PY - 2018/12/1

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N2 - Introduction: Fractional Anisotropy (FA) values are considered as a solid concrete index for determining white matter integrity in ageing and neurodegenerative diseases. FA is more comparable and reliable parameter than individual diffusivity parameters. A b-value and Time of Echo (TE) significantly affect the reproducibility and accuracy of Diffusion Tensor Imaging (DTI) derived indices at 1.5 Tesla (T) MRI machines in grey and white matter. Hence, no fixed b-value and TE protocol combination is recommended in literature to obtain consistent FA values, as it is a relatively new imaging technique. Aim: To check the consistency of FA values using different combinations of b-value and TE in DTI of normal brain white matter and to establish a standardised protocol for calculating FA values in different regions of normal brain white matter of the corpus callosum, centrum semiovale and pons. Materials and Methods: A cross-sectional study of 23 healthy participants without neurological abnormalities using 1.5 T MRI, DTI of brain white matter was performed. FA values were measured at the corpus callosum, centrum semiovale and pons using fiber track analysis in six different combinations of b-value and TE. Results: The FA values with least coefficient of variation was found with a b-value of 1000 s/mm2 and TE 100 ms. Conclusion: The current study established a standardised protocol for calculating FA values in different regions of normal brain white matter of the corpus callosum, centrum semiovale and pons.

AB - Introduction: Fractional Anisotropy (FA) values are considered as a solid concrete index for determining white matter integrity in ageing and neurodegenerative diseases. FA is more comparable and reliable parameter than individual diffusivity parameters. A b-value and Time of Echo (TE) significantly affect the reproducibility and accuracy of Diffusion Tensor Imaging (DTI) derived indices at 1.5 Tesla (T) MRI machines in grey and white matter. Hence, no fixed b-value and TE protocol combination is recommended in literature to obtain consistent FA values, as it is a relatively new imaging technique. Aim: To check the consistency of FA values using different combinations of b-value and TE in DTI of normal brain white matter and to establish a standardised protocol for calculating FA values in different regions of normal brain white matter of the corpus callosum, centrum semiovale and pons. Materials and Methods: A cross-sectional study of 23 healthy participants without neurological abnormalities using 1.5 T MRI, DTI of brain white matter was performed. FA values were measured at the corpus callosum, centrum semiovale and pons using fiber track analysis in six different combinations of b-value and TE. Results: The FA values with least coefficient of variation was found with a b-value of 1000 s/mm2 and TE 100 ms. Conclusion: The current study established a standardised protocol for calculating FA values in different regions of normal brain white matter of the corpus callosum, centrum semiovale and pons.

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