Convenient access to 1,3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation

N. Satheesha Rai, Balakrishna Kalluraya, B. Lingappa, Shaliny Shenoy, Vedavati G. Puranic

Research output: Contribution to journalArticlepeer-review

135 Citations (Scopus)

Abstract

Novel 1-aryl-3-(5-nitro-2-thienyl)-4-aroyl-pyrazoles 7 have been synthesized by the 1,3-dipolar cycloaddition of 3-arylsydnones 3 with 1-aryl-3-(5-nitro-2-thienyl)-2-propyn-1-ones 6. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article.

Original languageEnglish
Pages (from-to)1715-1720
Number of pages6
JournalEuropean Journal of Medicinal Chemistry
Volume43
Issue number8
DOIs
Publication statusPublished - 08-2008

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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