Cord Blood Insulin Levels: It’s Correlation with Gender, Birth Weight and Placental Weight in Term Newborns

Afzal Ahmad, Rukmini Mysore Srikantiah, Charu Yadav, Ashish Agarwal, Poornima Ajay Manjrekar, Anupama Hegde

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The cause of more insulin resistance in female than males are still unknown. To know the cause from early life, normal values of relevant parameters are required. So, aim of this study was to determine the reference levels of glucose and insulin in cord blood of term newborns and to examine their effects on gender, placental and birth weight of term newborns. In cross sectional study 60 consecutive term newborns were included from constituent hospitals. Placental and birth weights were measured and cord blood was collected for estimation of serum insulin and plasma glucose. Plasma glucose estimation was done by auto analyzer (GOD–POD method) and serum insulin analysis was done using Insulin ELISA Kit. After analysis, mean ± 2SD used for estimating cord blood insulin and glucose levels, which were 10.1 ± 7.8 μIU/mL and 67.8 ± 33.8 mg/dL respectively. Correlation of insulin with both birth weight and placental weight were r = 0.359 and 0.41 respectively; p < 0.001. Interestingly we found higher insulin levels in females as compared to male newborns in spite of having lower birth weight in them. In conclusion this study reported the levels of insulin and glucose in cord blood of term newborns. Incidentally, this is the first study as per our knowledge to report significant correlation between cord blood insulin, glucose with birth weight, placental weight and gender in south India. Female newborns had higher insulin levels than males, despite lesser birth weight can be attributed to intrinsic insulin resistance in them.

Original languageEnglish
Pages (from-to)458-462
Number of pages5
JournalIndian Journal of Clinical Biochemistry
Volume31
Issue number4
DOIs
Publication statusPublished - 01-10-2016

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

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