Correlation between insulin resistance and severity of coronary artery disease in non-diabetes

Rohit Shenoy, Rajesh Bhat, Mukund Srinivasan, Chakrapani Mahabala, Unnikrishnan Bhaskaran

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: There is an increased risk of coronary artery disease (CAD) in both diabetes and non-diabetes. Insulin resistance (IR) has been associated with the development of CAD in this both populations. However, there are not many studies on correlation between IR and severity of CAD in non-diabetes. This study aimed to establish a correlation between IR and severity of CAD in non-diabetic individuals. Methods: A cross-sectional study of 79 consecutive non-diabetic patients undergoing coronary angiogram for evaluation of clinically suspected CAD at a tertiary care hospital in Mangalore, Karnataka, were recruited. Clinical history, anthropometric, and biochemical parameters were analyzed. IR was determined by homeostasis model assessment-IR (HOMA-IR). The severity of CAD was assessed by Modified Gensini score. A Pearson correlation was done to find out the relation between HOMA-IR and Gensini core. Results: The correlation between log of HOMA-IR and severity of CAD as assessed by Gensini score (r=−0.053 and p=0.64) was not significant in non-diabetic patients. The correlations between severity of CAD and other known risk factors of CAD were also was not significant. Conclusions: HOMA-IR is negatively associated with severity of CAD in non-diabetes.

Original languageEnglish
Pages (from-to)331-333
Number of pages3
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume9
Issue number6
DOIs
Publication statusPublished - 01-11-2016

Fingerprint

Insulin Resistance
Coronary Artery Disease
Homeostasis
Tertiary Healthcare
Tertiary Care Centers
Angiography
Cross-Sectional Studies
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

@article{c9033ce0ba69451881cc076115bd2af9,
title = "Correlation between insulin resistance and severity of coronary artery disease in non-diabetes",
abstract = "Objective: There is an increased risk of coronary artery disease (CAD) in both diabetes and non-diabetes. Insulin resistance (IR) has been associated with the development of CAD in this both populations. However, there are not many studies on correlation between IR and severity of CAD in non-diabetes. This study aimed to establish a correlation between IR and severity of CAD in non-diabetic individuals. Methods: A cross-sectional study of 79 consecutive non-diabetic patients undergoing coronary angiogram for evaluation of clinically suspected CAD at a tertiary care hospital in Mangalore, Karnataka, were recruited. Clinical history, anthropometric, and biochemical parameters were analyzed. IR was determined by homeostasis model assessment-IR (HOMA-IR). The severity of CAD was assessed by Modified Gensini score. A Pearson correlation was done to find out the relation between HOMA-IR and Gensini core. Results: The correlation between log of HOMA-IR and severity of CAD as assessed by Gensini score (r=−0.053 and p=0.64) was not significant in non-diabetic patients. The correlations between severity of CAD and other known risk factors of CAD were also was not significant. Conclusions: HOMA-IR is negatively associated with severity of CAD in non-diabetes.",
author = "Rohit Shenoy and Rajesh Bhat and Mukund Srinivasan and Chakrapani Mahabala and Unnikrishnan Bhaskaran",
year = "2016",
month = "11",
day = "1",
doi = "10.22159/ajpcr.2016.v9i6.14637",
language = "English",
volume = "9",
pages = "331--333",
journal = "Asian Journal of Pharmaceutical and Clinical Research",
issn = "0974-2441",
publisher = "Innovare Academics Sciences Pvt. Ltd",
number = "6",

}

Correlation between insulin resistance and severity of coronary artery disease in non-diabetes. / Shenoy, Rohit; Bhat, Rajesh; Srinivasan, Mukund; Mahabala, Chakrapani; Bhaskaran, Unnikrishnan.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, No. 6, 01.11.2016, p. 331-333.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation between insulin resistance and severity of coronary artery disease in non-diabetes

AU - Shenoy, Rohit

AU - Bhat, Rajesh

AU - Srinivasan, Mukund

AU - Mahabala, Chakrapani

AU - Bhaskaran, Unnikrishnan

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Objective: There is an increased risk of coronary artery disease (CAD) in both diabetes and non-diabetes. Insulin resistance (IR) has been associated with the development of CAD in this both populations. However, there are not many studies on correlation between IR and severity of CAD in non-diabetes. This study aimed to establish a correlation between IR and severity of CAD in non-diabetic individuals. Methods: A cross-sectional study of 79 consecutive non-diabetic patients undergoing coronary angiogram for evaluation of clinically suspected CAD at a tertiary care hospital in Mangalore, Karnataka, were recruited. Clinical history, anthropometric, and biochemical parameters were analyzed. IR was determined by homeostasis model assessment-IR (HOMA-IR). The severity of CAD was assessed by Modified Gensini score. A Pearson correlation was done to find out the relation between HOMA-IR and Gensini core. Results: The correlation between log of HOMA-IR and severity of CAD as assessed by Gensini score (r=−0.053 and p=0.64) was not significant in non-diabetic patients. The correlations between severity of CAD and other known risk factors of CAD were also was not significant. Conclusions: HOMA-IR is negatively associated with severity of CAD in non-diabetes.

AB - Objective: There is an increased risk of coronary artery disease (CAD) in both diabetes and non-diabetes. Insulin resistance (IR) has been associated with the development of CAD in this both populations. However, there are not many studies on correlation between IR and severity of CAD in non-diabetes. This study aimed to establish a correlation between IR and severity of CAD in non-diabetic individuals. Methods: A cross-sectional study of 79 consecutive non-diabetic patients undergoing coronary angiogram for evaluation of clinically suspected CAD at a tertiary care hospital in Mangalore, Karnataka, were recruited. Clinical history, anthropometric, and biochemical parameters were analyzed. IR was determined by homeostasis model assessment-IR (HOMA-IR). The severity of CAD was assessed by Modified Gensini score. A Pearson correlation was done to find out the relation between HOMA-IR and Gensini core. Results: The correlation between log of HOMA-IR and severity of CAD as assessed by Gensini score (r=−0.053 and p=0.64) was not significant in non-diabetic patients. The correlations between severity of CAD and other known risk factors of CAD were also was not significant. Conclusions: HOMA-IR is negatively associated with severity of CAD in non-diabetes.

UR - http://www.scopus.com/inward/record.url?scp=84994908456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994908456&partnerID=8YFLogxK

U2 - 10.22159/ajpcr.2016.v9i6.14637

DO - 10.22159/ajpcr.2016.v9i6.14637

M3 - Article

VL - 9

SP - 331

EP - 333

JO - Asian Journal of Pharmaceutical and Clinical Research

JF - Asian Journal of Pharmaceutical and Clinical Research

SN - 0974-2441

IS - 6

ER -