Correlation between serum ferritin and bone marrow iron stores

V. Anupama, Purnima S. Rao, Sushma Adappa, Prashantha Balanthimogru, Chakrapani Mahabala

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Bone marrow aspirate examination is a gold standard to assess bone marrow iron stores. The correlation between serum ferritin and bone marrow iron has not been established in detail, as the cutoff value for iron stores have not been uniformly established. Ours was a cross-sectional study. Perl’s Prussian blue stain was used to stain bone marrow, assessed by Gale’s grading. Receiver operating characteristic curve analysis and Spearman’s correlation coefficient calculated. Gale’s grading revealed iron store deficiency in 26 and sufficiency in 13. Spearman’s correlation coefficient of 0.90 showed a significant relation between serum ferritin and bone marrow iron stores. A serum ferritin of 228 pmol/L had high sensitivity and specificity for iron deficiency; our study suggests that this level be taken as the cutoff value to predict iron store deficiency in bone marrow.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalTropical Doctor
Volume47
Issue number3
DOIs
Publication statusPublished - 01-07-2017

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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