Serum Magnesium (Mg) plays a significant role in cardiac homeostasis, and its deficiency is capable of producing myocardial injuries. Studies have suggested that magnesium deficient myocardial tissues were rendered susceptible to oxidative stress and also caused a significant increase in lipid peroxidation products the following ischemia. The present study aimed to find the association between hypomagnesemia and serum Malondialdehyde (MDA) levels and to assess the oxidative stress due to Myocardial infarction (MI). The present study was conducted on 112 subjects, which included 61 patients who had episodes of MI and 51 controls. The blood samples were collected within 12 hours after the onset of chest pain. The samples collected were used for the estimation of magnesium using Calmagite method and cardiac markers were analyzed in Cobas 6000.MDA was measured as thiobarbituric acid reactive substance. The patients with MI were found to have low levels of serum magnesium and high levels of serum MDA. A significant correlation was found between the serum levels of magnesium and MDA. The present study showed a high significant correlation between hypomagnesemia occurring in MI with MDA levels in serum, suggesting the evaluation of serum magnesium to be considered in strategies aimed at preventing and controlling the increase in oxidative stress in these patients.
|Number of pages||5|
|Journal||Research Journal of Pharmaceutical, Biological and Chemical Sciences|
|Publication status||Published - 01-09-2016|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)