Abstract

Background: Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail. Aims: The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus. Materials and Methods: In a cross-sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein-cholesterol ratio were determined. Homeostasis model assessment-IR (HOMA-IR) was correlated with severity of CAD, which was measured by modified Gensini Score. Results: There was a significant correlation between log HOMA-IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant. Conclusions: The results of our study indicate that we might able to predict the severity of CAD by measure of IR.

Original languageEnglish
Pages (from-to)611-614
Number of pages4
JournalNorth American Journal of Medical Sciences
Volume5
Issue number10
Publication statusPublished - 10-2013

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Insulin Resistance
Coronary Artery Disease
Type 2 Diabetes Mellitus
Fasting
Homeostasis
Blood Pressure
HDL Cholesterol
Blood Glucose
Angiography
Cross-Sectional Studies
Cholesterol
Insulin

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{c0f49a66fd3b47818ce5355f7a041bc7,
title = "Correlation of severity of coronary artery disease with insulin resistance",
abstract = "Background: Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail. Aims: The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus. Materials and Methods: In a cross-sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein-cholesterol ratio were determined. Homeostasis model assessment-IR (HOMA-IR) was correlated with severity of CAD, which was measured by modified Gensini Score. Results: There was a significant correlation between log HOMA-IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant. Conclusions: The results of our study indicate that we might able to predict the severity of CAD by measure of IR.",
author = "Srinivasan, {Mukund P.} and Kamath, {Padmanabh K.} and Manjrekar, {Poornima A.} and B. Unnikrishnan and Aishwarya Ullal and Kotekar, {Mohammed Faheem} and Chakrapani Mahabala",
year = "2013",
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language = "English",
volume = "5",
pages = "611--614",
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Correlation of severity of coronary artery disease with insulin resistance. / Srinivasan, Mukund P.; Kamath, Padmanabh K.; Manjrekar, Poornima A.; Unnikrishnan, B.; Ullal, Aishwarya; Kotekar, Mohammed Faheem; Mahabala, Chakrapani.

In: North American Journal of Medical Sciences, Vol. 5, No. 10, 10.2013, p. 611-614.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Correlation of severity of coronary artery disease with insulin resistance

AU - Srinivasan, Mukund P.

AU - Kamath, Padmanabh K.

AU - Manjrekar, Poornima A.

AU - Unnikrishnan, B.

AU - Ullal, Aishwarya

AU - Kotekar, Mohammed Faheem

AU - Mahabala, Chakrapani

PY - 2013/10

Y1 - 2013/10

N2 - Background: Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail. Aims: The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus. Materials and Methods: In a cross-sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein-cholesterol ratio were determined. Homeostasis model assessment-IR (HOMA-IR) was correlated with severity of CAD, which was measured by modified Gensini Score. Results: There was a significant correlation between log HOMA-IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant. Conclusions: The results of our study indicate that we might able to predict the severity of CAD by measure of IR.

AB - Background: Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail. Aims: The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus. Materials and Methods: In a cross-sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein-cholesterol ratio were determined. Homeostasis model assessment-IR (HOMA-IR) was correlated with severity of CAD, which was measured by modified Gensini Score. Results: There was a significant correlation between log HOMA-IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant. Conclusions: The results of our study indicate that we might able to predict the severity of CAD by measure of IR.

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