Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastruspaniculatus seed oil: Neurobehavioural, biochemical, histological study

Mrinmoy Chakrabarty, Priyanka Bhat, Sweta Kumari, Avin D'Souza, K. L. Bairy, Abhishek Chaturvedi, Archana Natarajan, K. G. Mohandas Rao, Shobha Kamath

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: To investigate the effects of Celastruspaniculatus seed oil in preventing the onset of chronic aluminum induced cortico-hippocampal neurodegeneration and oxidative stress. Materials and Methods: An animal model of senile dementia of Alzheimer's type wasproduced by administering aluminum as aluminum chloride (4.2 mg/kg) intraperitoneally to male Wistar rats for 60days and results compared to untreated control. Neurobehavioral investigations of Morris water maze tests, passive avoidance test, rotarod test and biochemical estimations of acetylcholineterase, malondialdehyde, glucose-6-phosphate dehydrogenase, superoxide dismutase, and hemoglobin in blood were performed fortnightly which gauged the extent of global oxidative stress and progressive neural damage. Findings were fortified by the above enzyme assays and histology of brain at necropsy. Prophylactic oral C. paniculatus in two doses 0.5 ml and 1 ml, were given to animals and the results were analyzed in comparison to a similar rodent model with standard drug donepezil (0.5 mg/kg) intraperitoneally. Results: C. paniculatus showed a significant prevention in onset of aluminum induced neural insult and overall systemic oxidative stress which was corroborated by the enlisted neurobehavioral, biochemical, and histological evidence. Conclusion: C. paniculatus is a putative decelerator of Al-mediated Alzheimer's like pathobiology.

Original languageEnglish
Pages (from-to)161-171
Number of pages11
JournalJournal of Pharmacology and Pharmacotherapeutics
Volume3
Issue number2
DOIs
Publication statusPublished - 01-04-2012

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Aluminum
Seeds
Oils
Oxidative Stress
Rotarod Performance Test
Glucosephosphate Dehydrogenase
Enzyme Assays
Malondialdehyde
Superoxide Dismutase
Wistar Rats
Rodentia
Histology
Alzheimer Disease
Hemoglobins
Animal Models
Water
Brain
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

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abstract = "Objective: To investigate the effects of Celastruspaniculatus seed oil in preventing the onset of chronic aluminum induced cortico-hippocampal neurodegeneration and oxidative stress. Materials and Methods: An animal model of senile dementia of Alzheimer's type wasproduced by administering aluminum as aluminum chloride (4.2 mg/kg) intraperitoneally to male Wistar rats for 60days and results compared to untreated control. Neurobehavioral investigations of Morris water maze tests, passive avoidance test, rotarod test and biochemical estimations of acetylcholineterase, malondialdehyde, glucose-6-phosphate dehydrogenase, superoxide dismutase, and hemoglobin in blood were performed fortnightly which gauged the extent of global oxidative stress and progressive neural damage. Findings were fortified by the above enzyme assays and histology of brain at necropsy. Prophylactic oral C. paniculatus in two doses 0.5 ml and 1 ml, were given to animals and the results were analyzed in comparison to a similar rodent model with standard drug donepezil (0.5 mg/kg) intraperitoneally. Results: C. paniculatus showed a significant prevention in onset of aluminum induced neural insult and overall systemic oxidative stress which was corroborated by the enlisted neurobehavioral, biochemical, and histological evidence. Conclusion: C. paniculatus is a putative decelerator of Al-mediated Alzheimer's like pathobiology.",
author = "Mrinmoy Chakrabarty and Priyanka Bhat and Sweta Kumari and Avin D'Souza and Bairy, {K. L.} and Abhishek Chaturvedi and Archana Natarajan and {Mohandas Rao}, {K. G.} and Shobha Kamath",
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Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastruspaniculatus seed oil : Neurobehavioural, biochemical, histological study. / Chakrabarty, Mrinmoy; Bhat, Priyanka; Kumari, Sweta; D'Souza, Avin; Bairy, K. L.; Chaturvedi, Abhishek; Natarajan, Archana; Mohandas Rao, K. G.; Kamath, Shobha.

In: Journal of Pharmacology and Pharmacotherapeutics, Vol. 3, No. 2, 01.04.2012, p. 161-171.

Research output: Contribution to journalArticle

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T1 - Cortico-hippocampal salvage in chronic aluminium induced neurodegeneration by Celastruspaniculatus seed oil

T2 - Neurobehavioural, biochemical, histological study

AU - Chakrabarty, Mrinmoy

AU - Bhat, Priyanka

AU - Kumari, Sweta

AU - D'Souza, Avin

AU - Bairy, K. L.

AU - Chaturvedi, Abhishek

AU - Natarajan, Archana

AU - Mohandas Rao, K. G.

AU - Kamath, Shobha

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Objective: To investigate the effects of Celastruspaniculatus seed oil in preventing the onset of chronic aluminum induced cortico-hippocampal neurodegeneration and oxidative stress. Materials and Methods: An animal model of senile dementia of Alzheimer's type wasproduced by administering aluminum as aluminum chloride (4.2 mg/kg) intraperitoneally to male Wistar rats for 60days and results compared to untreated control. Neurobehavioral investigations of Morris water maze tests, passive avoidance test, rotarod test and biochemical estimations of acetylcholineterase, malondialdehyde, glucose-6-phosphate dehydrogenase, superoxide dismutase, and hemoglobin in blood were performed fortnightly which gauged the extent of global oxidative stress and progressive neural damage. Findings were fortified by the above enzyme assays and histology of brain at necropsy. Prophylactic oral C. paniculatus in two doses 0.5 ml and 1 ml, were given to animals and the results were analyzed in comparison to a similar rodent model with standard drug donepezil (0.5 mg/kg) intraperitoneally. Results: C. paniculatus showed a significant prevention in onset of aluminum induced neural insult and overall systemic oxidative stress which was corroborated by the enlisted neurobehavioral, biochemical, and histological evidence. Conclusion: C. paniculatus is a putative decelerator of Al-mediated Alzheimer's like pathobiology.

AB - Objective: To investigate the effects of Celastruspaniculatus seed oil in preventing the onset of chronic aluminum induced cortico-hippocampal neurodegeneration and oxidative stress. Materials and Methods: An animal model of senile dementia of Alzheimer's type wasproduced by administering aluminum as aluminum chloride (4.2 mg/kg) intraperitoneally to male Wistar rats for 60days and results compared to untreated control. Neurobehavioral investigations of Morris water maze tests, passive avoidance test, rotarod test and biochemical estimations of acetylcholineterase, malondialdehyde, glucose-6-phosphate dehydrogenase, superoxide dismutase, and hemoglobin in blood were performed fortnightly which gauged the extent of global oxidative stress and progressive neural damage. Findings were fortified by the above enzyme assays and histology of brain at necropsy. Prophylactic oral C. paniculatus in two doses 0.5 ml and 1 ml, were given to animals and the results were analyzed in comparison to a similar rodent model with standard drug donepezil (0.5 mg/kg) intraperitoneally. Results: C. paniculatus showed a significant prevention in onset of aluminum induced neural insult and overall systemic oxidative stress which was corroborated by the enlisted neurobehavioral, biochemical, and histological evidence. Conclusion: C. paniculatus is a putative decelerator of Al-mediated Alzheimer's like pathobiology.

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