Corticosteroids - Assets and liabilities on periodontium

Nadimpalli Harshita, Deepa G. Kamath, Swati

Research output: Contribution to journalReview article

Abstract

Corticosteroids are chemically similar to endogenous cortisol and are used fundamentally as replacement therapy in patients with adrenal insufficiency, and used as anti-inflammatory agents. They are widely used in systemic diseases such as rheumatoid arthritis, asthma, and connective tissue disorders. In dentistry primarily these are used to decrease post-operative pain and edema in inflammatory diseases such as oral lichen planus, pemphigus, and recurrent aphthous stomatitis. This action is predominantly due to eicosanoid formation that inhibits phospholipase A2 activity. Corticosteroids can be supplemented either topically systemically or as inhalational therapy. Research suggests that local application of corticosteroids shows favorable effect on the periodontal ligament and possesses antiresorptive effect, but long-term systemic therapy is a risk for periodontal diseases which may provoke attachment loss and disruption of transseptal fibers. Oral manifestations are common with the use of inhaled steroids and are dependent on dose, frequency, duration, and inhaler use. It is commonly associated with ulceration of tongue, buccal mucosa, and occasionally on the gingiva due to xerostomia and immune suppression. It also causes a decrease in bone mineral density. This review explains about various effects of different types of corticosteroids on periodontium used in dentistry.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume11
Issue number8
DOIs
Publication statusPublished - 01-01-2018

Fingerprint

Periodontium
Adrenal Cortex Hormones
Dentistry
Oral Lichen Planus
Oral Manifestations
Xerostomia
Adrenal Insufficiency
Periodontal Ligament
Pemphigus
Eicosanoids
Nebulizers and Vaporizers
Phospholipases A2
Mouth Mucosa
Gingiva
Periodontal Diseases
Tongue
Connective Tissue
Bone Density
Hydrocortisone
Edema

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

Harshita, Nadimpalli ; Kamath, Deepa G. ; Swati. / Corticosteroids - Assets and liabilities on periodontium. In: Asian Journal of Pharmaceutical and Clinical Research. 2018 ; Vol. 11, No. 8. pp. 56-60.
@article{d42fcdf0c89346b38d556cabcc3b80cb,
title = "Corticosteroids - Assets and liabilities on periodontium",
abstract = "Corticosteroids are chemically similar to endogenous cortisol and are used fundamentally as replacement therapy in patients with adrenal insufficiency, and used as anti-inflammatory agents. They are widely used in systemic diseases such as rheumatoid arthritis, asthma, and connective tissue disorders. In dentistry primarily these are used to decrease post-operative pain and edema in inflammatory diseases such as oral lichen planus, pemphigus, and recurrent aphthous stomatitis. This action is predominantly due to eicosanoid formation that inhibits phospholipase A2 activity. Corticosteroids can be supplemented either topically systemically or as inhalational therapy. Research suggests that local application of corticosteroids shows favorable effect on the periodontal ligament and possesses antiresorptive effect, but long-term systemic therapy is a risk for periodontal diseases which may provoke attachment loss and disruption of transseptal fibers. Oral manifestations are common with the use of inhaled steroids and are dependent on dose, frequency, duration, and inhaler use. It is commonly associated with ulceration of tongue, buccal mucosa, and occasionally on the gingiva due to xerostomia and immune suppression. It also causes a decrease in bone mineral density. This review explains about various effects of different types of corticosteroids on periodontium used in dentistry.",
author = "Nadimpalli Harshita and Kamath, {Deepa G.} and Swati",
year = "2018",
month = "1",
day = "1",
doi = "10.22159/ajpcr.2018.v11i8.25442",
language = "English",
volume = "11",
pages = "56--60",
journal = "Asian Journal of Pharmaceutical and Clinical Research",
issn = "0974-2441",
publisher = "Innovare Academics Sciences Pvt. Ltd",
number = "8",

}

Corticosteroids - Assets and liabilities on periodontium. / Harshita, Nadimpalli; Kamath, Deepa G.; Swati.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, No. 8, 01.01.2018, p. 56-60.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Corticosteroids - Assets and liabilities on periodontium

AU - Harshita, Nadimpalli

AU - Kamath, Deepa G.

AU - Swati,

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Corticosteroids are chemically similar to endogenous cortisol and are used fundamentally as replacement therapy in patients with adrenal insufficiency, and used as anti-inflammatory agents. They are widely used in systemic diseases such as rheumatoid arthritis, asthma, and connective tissue disorders. In dentistry primarily these are used to decrease post-operative pain and edema in inflammatory diseases such as oral lichen planus, pemphigus, and recurrent aphthous stomatitis. This action is predominantly due to eicosanoid formation that inhibits phospholipase A2 activity. Corticosteroids can be supplemented either topically systemically or as inhalational therapy. Research suggests that local application of corticosteroids shows favorable effect on the periodontal ligament and possesses antiresorptive effect, but long-term systemic therapy is a risk for periodontal diseases which may provoke attachment loss and disruption of transseptal fibers. Oral manifestations are common with the use of inhaled steroids and are dependent on dose, frequency, duration, and inhaler use. It is commonly associated with ulceration of tongue, buccal mucosa, and occasionally on the gingiva due to xerostomia and immune suppression. It also causes a decrease in bone mineral density. This review explains about various effects of different types of corticosteroids on periodontium used in dentistry.

AB - Corticosteroids are chemically similar to endogenous cortisol and are used fundamentally as replacement therapy in patients with adrenal insufficiency, and used as anti-inflammatory agents. They are widely used in systemic diseases such as rheumatoid arthritis, asthma, and connective tissue disorders. In dentistry primarily these are used to decrease post-operative pain and edema in inflammatory diseases such as oral lichen planus, pemphigus, and recurrent aphthous stomatitis. This action is predominantly due to eicosanoid formation that inhibits phospholipase A2 activity. Corticosteroids can be supplemented either topically systemically or as inhalational therapy. Research suggests that local application of corticosteroids shows favorable effect on the periodontal ligament and possesses antiresorptive effect, but long-term systemic therapy is a risk for periodontal diseases which may provoke attachment loss and disruption of transseptal fibers. Oral manifestations are common with the use of inhaled steroids and are dependent on dose, frequency, duration, and inhaler use. It is commonly associated with ulceration of tongue, buccal mucosa, and occasionally on the gingiva due to xerostomia and immune suppression. It also causes a decrease in bone mineral density. This review explains about various effects of different types of corticosteroids on periodontium used in dentistry.

UR - http://www.scopus.com/inward/record.url?scp=85051262764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051262764&partnerID=8YFLogxK

U2 - 10.22159/ajpcr.2018.v11i8.25442

DO - 10.22159/ajpcr.2018.v11i8.25442

M3 - Review article

VL - 11

SP - 56

EP - 60

JO - Asian Journal of Pharmaceutical and Clinical Research

JF - Asian Journal of Pharmaceutical and Clinical Research

SN - 0974-2441

IS - 8

ER -