Critical biomarkers of epithelial-mesenchymal transition in the head and neck cancers

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Epithelial-mesenchymal transition (EMT), a key developmental program has been shown to occur in wound healing, organ fibrosis and in the initiation of metastasis for cancer progression. EMT is a process that describes the development of motile, mesenchymal-like cells from non-motile parent epithelial cells. Plasticity of the cells enable significant changes in cell phenotypes and this process is governed by the interplay among different functional classes of regulatory molecules. The process typically involves the control of specific gene expression programs with distinct functional impacts on the behavior of cells. An important feature of cellular plasticity, EMT has in the recent times attracted broad interest in the field of cancer research, tumor invasion and metastases. A complete understanding of the molecular events of EMT and a search for novel molecular regulators is required for prospective targets for therapeutic interventions. This review summarizes the critical biomarkers of EMT in the head and neck cancers.

Original languageEnglish
Pages (from-to)512-518
Number of pages7
JournalJournal of Cancer Research and Therapeutics
Volume10
Issue number3
DOIs
Publication statusPublished - 01-07-2014

Fingerprint

Epithelial-Mesenchymal Transition
Head and Neck Neoplasms
Biomarkers
Neoplasm Metastasis
Neoplasms
Wound Healing
Fibrosis
Epithelial Cells
Phenotype
Gene Expression
Research

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Critical biomarkers of epithelial-mesenchymal transition in the head and neck cancers",
abstract = "Epithelial-mesenchymal transition (EMT), a key developmental program has been shown to occur in wound healing, organ fibrosis and in the initiation of metastasis for cancer progression. EMT is a process that describes the development of motile, mesenchymal-like cells from non-motile parent epithelial cells. Plasticity of the cells enable significant changes in cell phenotypes and this process is governed by the interplay among different functional classes of regulatory molecules. The process typically involves the control of specific gene expression programs with distinct functional impacts on the behavior of cells. An important feature of cellular plasticity, EMT has in the recent times attracted broad interest in the field of cancer research, tumor invasion and metastases. A complete understanding of the molecular events of EMT and a search for novel molecular regulators is required for prospective targets for therapeutic interventions. This review summarizes the critical biomarkers of EMT in the head and neck cancers.",
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Critical biomarkers of epithelial-mesenchymal transition in the head and neck cancers. / Natarajan, Jayalakshmi; Chandrashekar, Chetana; Radhakrishnan, Raghu.

In: Journal of Cancer Research and Therapeutics, Vol. 10, No. 3, 01.07.2014, p. 512-518.

Research output: Contribution to journalReview article

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