Critical Values of Facet Joint Angulation and Tropism in the Development of Lumbar Degenerative Spondylolisthesis

An International, Large-Scale Multicenter Study by the AOSpine Asia Pacific Research Collaboration Consortium

Dino Samartzis, Jason Pui Yin Cheung, Shanmuganathan Rajasekaran, Yoshiharu Kawaguchi, Shankar Acharya, Mamoru Kawakami, Shigenobu Satoh, Wen Jer Chen, Chun Kun Park, Chong Suh Lee, Thanit Foocharoen, Hideki Nagashima, Sunguk Kuh, Zhaomin Zheng, Richard Condor, Manabu Ito, Motoki Iwasaki, Je Hoon Jeong, Keith D.K. Luk, Bambang Prijambodo & 18 others Amol Rege, Tae Ahn Jahng, Zhuojing Luo, Warat Tassanawipas, Narayana Acharya, Rohit Pokharel, Yong Shen, Takui Ito, Zhihai Zhang, Janardhana Aithala P, Gomatam Vijay Kumar, Rahyussalim Ahmad Jabir, Saumyajit Basu, Baojun Li, Vishal Moudgil, Ben Goss, Phoebe Sham, Richard Williams

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Study Design An international, multicenter cross-sectional image-based study performed in 33 institutions in the Asia Pacific region. Objective The study addressed the role of facet joint angulation and tropism in relation to L4-L5 degenerative spondylolisthesis (DS). Methods The study included 349 patients (63% females; mean age: 61.8 years) with single-level DS; 82 had no L4-L5 DS (group A) and 267 had L4-L5 DS (group B). Axial computed tomography and magnetic resonance imaging were utilized to assess facet joint angulations and tropism (i.e., asymmetry between facet joint angulations) between groups. Results There was a statistically significant difference between group A (left mean: 46.1 degrees; right mean: 48.2 degrees) and group B (left mean: 55.4 degrees; right mean: 57.5 degrees) in relation to bilateral L4-L5 facet joint angulations (p < 0.001). The mean bilateral angulation difference was 7.4 and 9.6 degrees in groups A and B, respectively (p = 0.025). A critical value of 58 degrees or greater significantly increased the likelihood of DS if unilateral (adjusted OR: 2.5; 95% CI: 1.2 to 5.5; p = 0.021) or bilateral facets (adjusted OR: 5.9; 95% CI: 2.7 to 13.2; p < 0.001) were involved. Facet joint tropism was found to be relevant between 16 and 24 degrees angulation difference (adjusted OR: 5.6; 95% CI: 1.2 to 26.1; p = 0.027). Conclusions In one of the largest studies assessing facet joint orientation in patients with DS, greater sagittal facet joint angulation was associated with L4-L5 DS, with a critical value of 58 degrees or greater increasing the likelihood of the condition for unilateral and bilateral facet joint involvement. Specific facet joint tropism categories were noted to be associated with DS.

Original languageEnglish
Pages (from-to)414-421
Number of pages8
JournalGlobal Spine Journal
Volume6
Issue number5
DOIs
Publication statusPublished - 01-08-2016
Externally publishedYes

Fingerprint

Zygapophyseal Joint
Spondylolisthesis
Tropism
Multicenter Studies
Research
Tomography
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

Samartzis, Dino ; Cheung, Jason Pui Yin ; Rajasekaran, Shanmuganathan ; Kawaguchi, Yoshiharu ; Acharya, Shankar ; Kawakami, Mamoru ; Satoh, Shigenobu ; Chen, Wen Jer ; Park, Chun Kun ; Lee, Chong Suh ; Foocharoen, Thanit ; Nagashima, Hideki ; Kuh, Sunguk ; Zheng, Zhaomin ; Condor, Richard ; Ito, Manabu ; Iwasaki, Motoki ; Jeong, Je Hoon ; Luk, Keith D.K. ; Prijambodo, Bambang ; Rege, Amol ; Jahng, Tae Ahn ; Luo, Zhuojing ; Tassanawipas, Warat ; Acharya, Narayana ; Pokharel, Rohit ; Shen, Yong ; Ito, Takui ; Zhang, Zhihai ; Aithala P, Janardhana ; Kumar, Gomatam Vijay ; Jabir, Rahyussalim Ahmad ; Basu, Saumyajit ; Li, Baojun ; Moudgil, Vishal ; Goss, Ben ; Sham, Phoebe ; Williams, Richard. / Critical Values of Facet Joint Angulation and Tropism in the Development of Lumbar Degenerative Spondylolisthesis : An International, Large-Scale Multicenter Study by the AOSpine Asia Pacific Research Collaboration Consortium. In: Global Spine Journal. 2016 ; Vol. 6, No. 5. pp. 414-421.
@article{832c61e33f5e4eaf8edcd4fd13b3b1f7,
title = "Critical Values of Facet Joint Angulation and Tropism in the Development of Lumbar Degenerative Spondylolisthesis: An International, Large-Scale Multicenter Study by the AOSpine Asia Pacific Research Collaboration Consortium",
abstract = "Study Design An international, multicenter cross-sectional image-based study performed in 33 institutions in the Asia Pacific region. Objective The study addressed the role of facet joint angulation and tropism in relation to L4-L5 degenerative spondylolisthesis (DS). Methods The study included 349 patients (63{\%} females; mean age: 61.8 years) with single-level DS; 82 had no L4-L5 DS (group A) and 267 had L4-L5 DS (group B). Axial computed tomography and magnetic resonance imaging were utilized to assess facet joint angulations and tropism (i.e., asymmetry between facet joint angulations) between groups. Results There was a statistically significant difference between group A (left mean: 46.1 degrees; right mean: 48.2 degrees) and group B (left mean: 55.4 degrees; right mean: 57.5 degrees) in relation to bilateral L4-L5 facet joint angulations (p < 0.001). The mean bilateral angulation difference was 7.4 and 9.6 degrees in groups A and B, respectively (p = 0.025). A critical value of 58 degrees or greater significantly increased the likelihood of DS if unilateral (adjusted OR: 2.5; 95{\%} CI: 1.2 to 5.5; p = 0.021) or bilateral facets (adjusted OR: 5.9; 95{\%} CI: 2.7 to 13.2; p < 0.001) were involved. Facet joint tropism was found to be relevant between 16 and 24 degrees angulation difference (adjusted OR: 5.6; 95{\%} CI: 1.2 to 26.1; p = 0.027). Conclusions In one of the largest studies assessing facet joint orientation in patients with DS, greater sagittal facet joint angulation was associated with L4-L5 DS, with a critical value of 58 degrees or greater increasing the likelihood of the condition for unilateral and bilateral facet joint involvement. Specific facet joint tropism categories were noted to be associated with DS.",
author = "Dino Samartzis and Cheung, {Jason Pui Yin} and Shanmuganathan Rajasekaran and Yoshiharu Kawaguchi and Shankar Acharya and Mamoru Kawakami and Shigenobu Satoh and Chen, {Wen Jer} and Park, {Chun Kun} and Lee, {Chong Suh} and Thanit Foocharoen and Hideki Nagashima and Sunguk Kuh and Zhaomin Zheng and Richard Condor and Manabu Ito and Motoki Iwasaki and Jeong, {Je Hoon} and Luk, {Keith D.K.} and Bambang Prijambodo and Amol Rege and Jahng, {Tae Ahn} and Zhuojing Luo and Warat Tassanawipas and Narayana Acharya and Rohit Pokharel and Yong Shen and Takui Ito and Zhihai Zhang and {Aithala P}, Janardhana and Kumar, {Gomatam Vijay} and Jabir, {Rahyussalim Ahmad} and Saumyajit Basu and Baojun Li and Vishal Moudgil and Ben Goss and Phoebe Sham and Richard Williams",
year = "2016",
month = "8",
day = "1",
doi = "10.1055/s-0035-1564417",
language = "English",
volume = "6",
pages = "414--421",
journal = "Global Spine Journal",
issn = "2192-5682",
publisher = "Thieme Medical Publishers",
number = "5",

}

Samartzis, D, Cheung, JPY, Rajasekaran, S, Kawaguchi, Y, Acharya, S, Kawakami, M, Satoh, S, Chen, WJ, Park, CK, Lee, CS, Foocharoen, T, Nagashima, H, Kuh, S, Zheng, Z, Condor, R, Ito, M, Iwasaki, M, Jeong, JH, Luk, KDK, Prijambodo, B, Rege, A, Jahng, TA, Luo, Z, Tassanawipas, W, Acharya, N, Pokharel, R, Shen, Y, Ito, T, Zhang, Z, Aithala P, J, Kumar, GV, Jabir, RA, Basu, S, Li, B, Moudgil, V, Goss, B, Sham, P & Williams, R 2016, 'Critical Values of Facet Joint Angulation and Tropism in the Development of Lumbar Degenerative Spondylolisthesis: An International, Large-Scale Multicenter Study by the AOSpine Asia Pacific Research Collaboration Consortium', Global Spine Journal, vol. 6, no. 5, pp. 414-421. https://doi.org/10.1055/s-0035-1564417

Critical Values of Facet Joint Angulation and Tropism in the Development of Lumbar Degenerative Spondylolisthesis : An International, Large-Scale Multicenter Study by the AOSpine Asia Pacific Research Collaboration Consortium. / Samartzis, Dino; Cheung, Jason Pui Yin; Rajasekaran, Shanmuganathan; Kawaguchi, Yoshiharu; Acharya, Shankar; Kawakami, Mamoru; Satoh, Shigenobu; Chen, Wen Jer; Park, Chun Kun; Lee, Chong Suh; Foocharoen, Thanit; Nagashima, Hideki; Kuh, Sunguk; Zheng, Zhaomin; Condor, Richard; Ito, Manabu; Iwasaki, Motoki; Jeong, Je Hoon; Luk, Keith D.K.; Prijambodo, Bambang; Rege, Amol; Jahng, Tae Ahn; Luo, Zhuojing; Tassanawipas, Warat; Acharya, Narayana; Pokharel, Rohit; Shen, Yong; Ito, Takui; Zhang, Zhihai; Aithala P, Janardhana; Kumar, Gomatam Vijay; Jabir, Rahyussalim Ahmad; Basu, Saumyajit; Li, Baojun; Moudgil, Vishal; Goss, Ben; Sham, Phoebe; Williams, Richard.

In: Global Spine Journal, Vol. 6, No. 5, 01.08.2016, p. 414-421.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Critical Values of Facet Joint Angulation and Tropism in the Development of Lumbar Degenerative Spondylolisthesis

T2 - An International, Large-Scale Multicenter Study by the AOSpine Asia Pacific Research Collaboration Consortium

AU - Samartzis, Dino

AU - Cheung, Jason Pui Yin

AU - Rajasekaran, Shanmuganathan

AU - Kawaguchi, Yoshiharu

AU - Acharya, Shankar

AU - Kawakami, Mamoru

AU - Satoh, Shigenobu

AU - Chen, Wen Jer

AU - Park, Chun Kun

AU - Lee, Chong Suh

AU - Foocharoen, Thanit

AU - Nagashima, Hideki

AU - Kuh, Sunguk

AU - Zheng, Zhaomin

AU - Condor, Richard

AU - Ito, Manabu

AU - Iwasaki, Motoki

AU - Jeong, Je Hoon

AU - Luk, Keith D.K.

AU - Prijambodo, Bambang

AU - Rege, Amol

AU - Jahng, Tae Ahn

AU - Luo, Zhuojing

AU - Tassanawipas, Warat

AU - Acharya, Narayana

AU - Pokharel, Rohit

AU - Shen, Yong

AU - Ito, Takui

AU - Zhang, Zhihai

AU - Aithala P, Janardhana

AU - Kumar, Gomatam Vijay

AU - Jabir, Rahyussalim Ahmad

AU - Basu, Saumyajit

AU - Li, Baojun

AU - Moudgil, Vishal

AU - Goss, Ben

AU - Sham, Phoebe

AU - Williams, Richard

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Study Design An international, multicenter cross-sectional image-based study performed in 33 institutions in the Asia Pacific region. Objective The study addressed the role of facet joint angulation and tropism in relation to L4-L5 degenerative spondylolisthesis (DS). Methods The study included 349 patients (63% females; mean age: 61.8 years) with single-level DS; 82 had no L4-L5 DS (group A) and 267 had L4-L5 DS (group B). Axial computed tomography and magnetic resonance imaging were utilized to assess facet joint angulations and tropism (i.e., asymmetry between facet joint angulations) between groups. Results There was a statistically significant difference between group A (left mean: 46.1 degrees; right mean: 48.2 degrees) and group B (left mean: 55.4 degrees; right mean: 57.5 degrees) in relation to bilateral L4-L5 facet joint angulations (p < 0.001). The mean bilateral angulation difference was 7.4 and 9.6 degrees in groups A and B, respectively (p = 0.025). A critical value of 58 degrees or greater significantly increased the likelihood of DS if unilateral (adjusted OR: 2.5; 95% CI: 1.2 to 5.5; p = 0.021) or bilateral facets (adjusted OR: 5.9; 95% CI: 2.7 to 13.2; p < 0.001) were involved. Facet joint tropism was found to be relevant between 16 and 24 degrees angulation difference (adjusted OR: 5.6; 95% CI: 1.2 to 26.1; p = 0.027). Conclusions In one of the largest studies assessing facet joint orientation in patients with DS, greater sagittal facet joint angulation was associated with L4-L5 DS, with a critical value of 58 degrees or greater increasing the likelihood of the condition for unilateral and bilateral facet joint involvement. Specific facet joint tropism categories were noted to be associated with DS.

AB - Study Design An international, multicenter cross-sectional image-based study performed in 33 institutions in the Asia Pacific region. Objective The study addressed the role of facet joint angulation and tropism in relation to L4-L5 degenerative spondylolisthesis (DS). Methods The study included 349 patients (63% females; mean age: 61.8 years) with single-level DS; 82 had no L4-L5 DS (group A) and 267 had L4-L5 DS (group B). Axial computed tomography and magnetic resonance imaging were utilized to assess facet joint angulations and tropism (i.e., asymmetry between facet joint angulations) between groups. Results There was a statistically significant difference between group A (left mean: 46.1 degrees; right mean: 48.2 degrees) and group B (left mean: 55.4 degrees; right mean: 57.5 degrees) in relation to bilateral L4-L5 facet joint angulations (p < 0.001). The mean bilateral angulation difference was 7.4 and 9.6 degrees in groups A and B, respectively (p = 0.025). A critical value of 58 degrees or greater significantly increased the likelihood of DS if unilateral (adjusted OR: 2.5; 95% CI: 1.2 to 5.5; p = 0.021) or bilateral facets (adjusted OR: 5.9; 95% CI: 2.7 to 13.2; p < 0.001) were involved. Facet joint tropism was found to be relevant between 16 and 24 degrees angulation difference (adjusted OR: 5.6; 95% CI: 1.2 to 26.1; p = 0.027). Conclusions In one of the largest studies assessing facet joint orientation in patients with DS, greater sagittal facet joint angulation was associated with L4-L5 DS, with a critical value of 58 degrees or greater increasing the likelihood of the condition for unilateral and bilateral facet joint involvement. Specific facet joint tropism categories were noted to be associated with DS.

UR - http://www.scopus.com/inward/record.url?scp=85017138499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017138499&partnerID=8YFLogxK

U2 - 10.1055/s-0035-1564417

DO - 10.1055/s-0035-1564417

M3 - Article

VL - 6

SP - 414

EP - 421

JO - Global Spine Journal

JF - Global Spine Journal

SN - 2192-5682

IS - 5

ER -