Curcuma zedoaria Rosc, (white turmeric): A review of its chemical, pharmacological and ethnomedicinal properties

R. Lobo, K.S. Prabhu, A. Shirwaikar

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Objectives Curcuma zedoaria Rosc is a perennial herb found in tropical countries, such as India, Japan and Thailand. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as diarrhoea, cancer, flatulence and dyspepsia. This study is an attempt to compile an up-to-date and comprehensive review of C. zedoaria that covers its traditional and folk medicinal uses, phytochemistry and pharmacology.
Original languageEnglish
Pages (from-to)13-21
Number of pages9
JournalJournal of Pharmacy and Pharmacology
Volume61
Issue number1
DOIs
Publication statusPublished - 2009

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Curcuma
Pharmacology
Flatulence
Dyspepsia
Traditional Medicine
Thailand
India
Diarrhea
Japan
Neoplasms
Therapeutics

Cite this

@article{6c0c41823bee4d9bbf04d8f6165e875b,
title = "Curcuma zedoaria Rosc, (white turmeric): A review of its chemical, pharmacological and ethnomedicinal properties",
abstract = "Objectives Curcuma zedoaria Rosc is a perennial herb found in tropical countries, such as India, Japan and Thailand. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as diarrhoea, cancer, flatulence and dyspepsia. This study is an attempt to compile an up-to-date and comprehensive review of C. zedoaria that covers its traditional and folk medicinal uses, phytochemistry and pharmacology.",
author = "R. Lobo and K.S. Prabhu and A. Shirwaikar",
note = "Cited By :54 Export Date: 10 November 2017 CODEN: JPPMA Correspondence Address: Shirwaikar, A.; Dept. of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: alpha phellandrene, 99-83-2; beta eudesmol, 3287-59-0, 473-15-4, 57605-77-3; cineole, 470-82-6, 55962-72-6; curcumin, 458-37-7; cymene, 25155-15-1; turmerone, 56485-42-8; zingiberene, 495-60-3; Analgesics; Anti-Inflammatory Agents; Antineoplastic Agents; Plant Extracts References: Wilson, B., Antimicrobial activity of Curcuma zedoaria and Curcuma malabarica tubers (2005) J Ethnopharmacol, 99, pp. 147-151; Nadkarni, K.M., (1999) Indian Materia Medica, , 3rd edn. Mumbai. India: Popular Prakashan Private Limited; Prajapati ND et al. Agro's Dictionary of Medicinal Plants. 1st edn. India: Agrobiosis, 2003; Etoh, H., 9-Oxo-neoprocurcumenol from Curcuma aromatica (Zingibereaceae) as an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincalis (2003) Biosci Biotechnol Biochem, 67, pp. 911-913; Maciel, N., Criley, R.A., Morphology, growth and flowering behavior of Curcuma zedoaria (2003) Acta Hort, 624, pp. 111-116; Khare, C.K., (2007) Indian Medicinal Plants: An illustrated Dictionary, , 1st edn, New Delhi, India: Springer Pvt Ltd; Joy, P.P., (1998) Medicinal Plants: Tropical Horticulture, , Calcutta, India: Naya Prakash; Makabe, H., Antiinflammatory sesquiterpenes from Curcuma zedoaria (2006) Nat Prod Res, 20, pp. 680-686; Navarro, N.D., Phytochemical analysis and analgesic properties of Curcuma zedoaria grown in Brazil (2002) Phytomedicine, 9, pp. 427-432; Christiane, R.P., Seasonal variation and analgesic properties of different parts from Curcuma zedoaria Roscoe (Zingiberaceae) grown in Brazil (2006) Z Naturforsch, 61, pp. 6-10; Matsuda, H., Inhibitors of nitric oxide production and new sesquiterpenes, zedoarofuran, 4-epicurcumenol, neocurcumenol, gajutsulactones A and B, and zedoarolides A and B, from Zedoariae Rhizoma (2001) Chem Pharm Bull, 49, pp. 1558-1566; Takano, I., Guaiane sesquiterpene lactones from Curcuma aeruginosa (1995) Phytochemistry, 40, pp. 1197-1200; Shiobara, Y., Zedoarol, 13-hydroxygermacrone and curzeone, three sesquiterpenoids from Curcuma zedoaria (1986) Phytochemistry, 25, pp. 1351-1353; Shiobara, Y., Curcumenone, curcumanolide A and curcumanolide B, three sesquiterpenoids from Curcuma zedoaria (1985) Phytochemistry, 24, pp. 2629-2633; Gupta, S.K., Isolation of ethyl pmethoxycinnamate, the major antifungal principle of Curcuma zedoaria (1976) Lloydia, 39, pp. 218-222; Hong, C.H., Sesquiterpenoids from the rhizome of Curcuma zedoaria (2001) Arch Pharm Res, 24, pp. 424-426; Mau, J.L., Composition and antioxidant activity of the essential oil from Curcuma zedoaria (2003) Food Chem, 82, pp. 583-591; Purkayastha, J., Essential oil of the rhizome of Curcuma zedoaria (Christm.) Rosc, native to northeast India (2006) J Essential Oil Res, 18, pp. 154-155; Singh, G., Chemical and biocidal investigations on essential oils of some Indian Curcuma species (2002) Progress Crystal Growth Charact Mat, 45, pp. 75-81; Garg, S.N., Chemical composition of the essential oil from the leaves of Curcuma zedoaria Rosc, of Indian origin (2005) J Essential Oil Res, 17, pp. 29-31; Chihiro, T., Comparison of antiinflammatory activities of six curcuma rhizomes: A possible curcuminoid independent pathway mediated by curcuma phaeocaulis extract (2006) Evid Based Complement Alternat Med, 3, pp. 255-260; Wan Jnr, S., Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoaria (1998) J Nat Prod, 61, pp. 1531-1534; Paramapojn, S., Gritsanapan, W., Variation of curcuminoids in ethanolic extract of Curcuma zedoaria rhizomes in Thailand by HPLC (2007) Planta Med, 73, pp. 797-1034; Yonzon, M., Antimicrobial activities of essential oils of Nepal (2005) J Essential Oil Res, 17, pp. 107-111; Uechi, S., Antibacterial activity of essential oil derived from Curcuma sp. (Zingiberaceae) against foodborne pathogenic bacteria and its heat-stability (2000) Sci Bull Faculty Agric, 47, pp. 129-136; Bugno, A., Antimicrobial efficacy of Curcuma zedoaria extract as assessed by linear regression compared with commercial mouthrinses (2007) Braz J Microbiol, 38, pp. 440-445; Ficker, C.E., Inhibition of human pathogenic fungi by members of Zingiberaceae used by the Kenyah (Indonesian Borneo) (2003) J Ethnopharmacol, 85, pp. 289-293; Ansari, M.H., Ahmad, S., Screening of some medicinal plants for antiamoebic action (1991) Fitoterapia, 62, pp. 171-175; Raghuveer, G.P.S., Evaluation of anti-ulcer effect of root of Curcuma zedoaria in rats (2004) Indian J Traditional Knowledge, 2, pp. 375-377; Latif, M., Toxicity of shoti (Indian arrowroot: Curcuma zedoaria) for rats and chick (1979) Br J Nutr, 41, pp. 57-63; Matsuda, H., Anti-allergic principles from Thai zedoary: Structural requirements of curcuminoids for inhibition of degranulation and effect on the release of TNF-a and IL-4 in RBL-2H3 cells (2004) Bioorg Med Chem, 12, pp. 5891-5898; Han, B.H., Screening of the inhibitory effect of herbal medicines on the platelet activating factor (PAF) binding: 35 selected herbal medicines based on folk medicinal informations (1995) Yakhak Hoeji, 39, pp. 10-13; Matsuda, H., Inhibitory effect and action mechanism of sesquiterpenes from zedoariae rhizoma on D-galactosamine/lipopolysaccharide- induced liver injury (1998) Bioorg Med Chem Lett, 8, pp. 339-344; Kim, D.I., The inhibitory effect of a Korean herbal medicine, Zedoariae rhizoma, on growth of cultured human hepatic myofibroblast cells (2005) Life Sci, 77, pp. 890-906; Sakda, D., Screening of plants containing Naja naja siamensis cobra venom inhibitory activity using modified ELISA technique (2005) Anal Biochem, 341, pp. 316-325; Polkit, S., Hemagglutinating activity of Curcuma plants (2007) Fitoterapia, 78, p. 29; Lee, H., Lin, J.Y., Antimutagenic activity of extracts from anticancer drugs in Chinese medicine (1988) Mutat Res, 204, pp. 229-234; Afhima, S., Cytotoxic activity of Thai medicinal plants for cancer treatment (2005) Songklanakarin J. Sci. Technol, 27, pp. 469-478; Myoungae, K., Cytotoxic activity of the extracts from Curcuma zedoaria (2003) J Toxicol Public Health, 19, pp. 293-296; Matthes, H.W., Cytotoxic components of Zingiber zerumbet, Curcuma zedoaria and C. domestica (1980) Phytochemistry, 19, pp. 2643-2650; Seo, W.-G., Suppressive effect of Zedoariae rhizoma on pulmonary metastasis of B16 melanoma cells (2005) J Ethnopharmacol, 101, pp. 249-257; Hong, C.H., Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells (2002) J Ethnopharmacol, 83, pp. 153-159; Miachir, J.I., Micropropagation and callogenesis of Curcuma zedoaria (2004) Sci Agric, 61, pp. 427-432; Cooper, E.L., Complementary and alternative medicine, when rigorous, can be science (2004) Evid Based Complement Alternat Med, 1, pp. 1-4; M{\"u}ller, W.E.G., Traditional and modern biomedical prospecting: Part I-the history. Sustainable exploitation of biodiversity (sponges and invertebrates) in the Adriatic Sea at Rovinj (Croatia) (2004) Evid Based Complement Alternat Med, 1, pp. 71-82; M{\"u}ller, W.E.G., Traditional and modern biomedical prospecting: Part II-the benefits. Approaches for a sustainable exploitation of biodiversity (secondary metabolites and biomaterials from sponges) (2004) Evid Based Complement Altern Med, 1, pp. 133-144; Patwardhan, B., Ayurveda and Traditional Chinese Medicine: A Comparative Overview (2005) Evid Based Complement Alternat Med, 2, pp. 465-473",
year = "2009",
doi = "10.1211/jpp/61.01.0003",
language = "English",
volume = "61",
pages = "13--21",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "Pharmaceutical Press",
number = "1",

}

Curcuma zedoaria Rosc, (white turmeric): A review of its chemical, pharmacological and ethnomedicinal properties. / Lobo, R.; Prabhu, K.S.; Shirwaikar, A.

In: Journal of Pharmacy and Pharmacology, Vol. 61, No. 1, 2009, p. 13-21.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Curcuma zedoaria Rosc, (white turmeric): A review of its chemical, pharmacological and ethnomedicinal properties

AU - Lobo, R.

AU - Prabhu, K.S.

AU - Shirwaikar, A.

N1 - Cited By :54 Export Date: 10 November 2017 CODEN: JPPMA Correspondence Address: Shirwaikar, A.; Dept. of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: alpha phellandrene, 99-83-2; beta eudesmol, 3287-59-0, 473-15-4, 57605-77-3; cineole, 470-82-6, 55962-72-6; curcumin, 458-37-7; cymene, 25155-15-1; turmerone, 56485-42-8; zingiberene, 495-60-3; Analgesics; Anti-Inflammatory Agents; Antineoplastic Agents; Plant Extracts References: Wilson, B., Antimicrobial activity of Curcuma zedoaria and Curcuma malabarica tubers (2005) J Ethnopharmacol, 99, pp. 147-151; Nadkarni, K.M., (1999) Indian Materia Medica, , 3rd edn. Mumbai. India: Popular Prakashan Private Limited; Prajapati ND et al. Agro's Dictionary of Medicinal Plants. 1st edn. India: Agrobiosis, 2003; Etoh, H., 9-Oxo-neoprocurcumenol from Curcuma aromatica (Zingibereaceae) as an attachment inhibitor against the blue mussel, Mytilus edulis galloprovincalis (2003) Biosci Biotechnol Biochem, 67, pp. 911-913; Maciel, N., Criley, R.A., Morphology, growth and flowering behavior of Curcuma zedoaria (2003) Acta Hort, 624, pp. 111-116; Khare, C.K., (2007) Indian Medicinal Plants: An illustrated Dictionary, , 1st edn, New Delhi, India: Springer Pvt Ltd; Joy, P.P., (1998) Medicinal Plants: Tropical Horticulture, , Calcutta, India: Naya Prakash; Makabe, H., Antiinflammatory sesquiterpenes from Curcuma zedoaria (2006) Nat Prod Res, 20, pp. 680-686; Navarro, N.D., Phytochemical analysis and analgesic properties of Curcuma zedoaria grown in Brazil (2002) Phytomedicine, 9, pp. 427-432; Christiane, R.P., Seasonal variation and analgesic properties of different parts from Curcuma zedoaria Roscoe (Zingiberaceae) grown in Brazil (2006) Z Naturforsch, 61, pp. 6-10; Matsuda, H., Inhibitors of nitric oxide production and new sesquiterpenes, zedoarofuran, 4-epicurcumenol, neocurcumenol, gajutsulactones A and B, and zedoarolides A and B, from Zedoariae Rhizoma (2001) Chem Pharm Bull, 49, pp. 1558-1566; Takano, I., Guaiane sesquiterpene lactones from Curcuma aeruginosa (1995) Phytochemistry, 40, pp. 1197-1200; Shiobara, Y., Zedoarol, 13-hydroxygermacrone and curzeone, three sesquiterpenoids from Curcuma zedoaria (1986) Phytochemistry, 25, pp. 1351-1353; Shiobara, Y., Curcumenone, curcumanolide A and curcumanolide B, three sesquiterpenoids from Curcuma zedoaria (1985) Phytochemistry, 24, pp. 2629-2633; Gupta, S.K., Isolation of ethyl pmethoxycinnamate, the major antifungal principle of Curcuma zedoaria (1976) Lloydia, 39, pp. 218-222; Hong, C.H., Sesquiterpenoids from the rhizome of Curcuma zedoaria (2001) Arch Pharm Res, 24, pp. 424-426; Mau, J.L., Composition and antioxidant activity of the essential oil from Curcuma zedoaria (2003) Food Chem, 82, pp. 583-591; Purkayastha, J., Essential oil of the rhizome of Curcuma zedoaria (Christm.) Rosc, native to northeast India (2006) J Essential Oil Res, 18, pp. 154-155; Singh, G., Chemical and biocidal investigations on essential oils of some Indian Curcuma species (2002) Progress Crystal Growth Charact Mat, 45, pp. 75-81; Garg, S.N., Chemical composition of the essential oil from the leaves of Curcuma zedoaria Rosc, of Indian origin (2005) J Essential Oil Res, 17, pp. 29-31; Chihiro, T., Comparison of antiinflammatory activities of six curcuma rhizomes: A possible curcuminoid independent pathway mediated by curcuma phaeocaulis extract (2006) Evid Based Complement Alternat Med, 3, pp. 255-260; Wan Jnr, S., Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoaria (1998) J Nat Prod, 61, pp. 1531-1534; Paramapojn, S., Gritsanapan, W., Variation of curcuminoids in ethanolic extract of Curcuma zedoaria rhizomes in Thailand by HPLC (2007) Planta Med, 73, pp. 797-1034; Yonzon, M., Antimicrobial activities of essential oils of Nepal (2005) J Essential Oil Res, 17, pp. 107-111; Uechi, S., Antibacterial activity of essential oil derived from Curcuma sp. (Zingiberaceae) against foodborne pathogenic bacteria and its heat-stability (2000) Sci Bull Faculty Agric, 47, pp. 129-136; Bugno, A., Antimicrobial efficacy of Curcuma zedoaria extract as assessed by linear regression compared with commercial mouthrinses (2007) Braz J Microbiol, 38, pp. 440-445; Ficker, C.E., Inhibition of human pathogenic fungi by members of Zingiberaceae used by the Kenyah (Indonesian Borneo) (2003) J Ethnopharmacol, 85, pp. 289-293; Ansari, M.H., Ahmad, S., Screening of some medicinal plants for antiamoebic action (1991) Fitoterapia, 62, pp. 171-175; Raghuveer, G.P.S., Evaluation of anti-ulcer effect of root of Curcuma zedoaria in rats (2004) Indian J Traditional Knowledge, 2, pp. 375-377; Latif, M., Toxicity of shoti (Indian arrowroot: Curcuma zedoaria) for rats and chick (1979) Br J Nutr, 41, pp. 57-63; Matsuda, H., Anti-allergic principles from Thai zedoary: Structural requirements of curcuminoids for inhibition of degranulation and effect on the release of TNF-a and IL-4 in RBL-2H3 cells (2004) Bioorg Med Chem, 12, pp. 5891-5898; Han, B.H., Screening of the inhibitory effect of herbal medicines on the platelet activating factor (PAF) binding: 35 selected herbal medicines based on folk medicinal informations (1995) Yakhak Hoeji, 39, pp. 10-13; Matsuda, H., Inhibitory effect and action mechanism of sesquiterpenes from zedoariae rhizoma on D-galactosamine/lipopolysaccharide- induced liver injury (1998) Bioorg Med Chem Lett, 8, pp. 339-344; Kim, D.I., The inhibitory effect of a Korean herbal medicine, Zedoariae rhizoma, on growth of cultured human hepatic myofibroblast cells (2005) Life Sci, 77, pp. 890-906; Sakda, D., Screening of plants containing Naja naja siamensis cobra venom inhibitory activity using modified ELISA technique (2005) Anal Biochem, 341, pp. 316-325; Polkit, S., Hemagglutinating activity of Curcuma plants (2007) Fitoterapia, 78, p. 29; Lee, H., Lin, J.Y., Antimutagenic activity of extracts from anticancer drugs in Chinese medicine (1988) Mutat Res, 204, pp. 229-234; Afhima, S., Cytotoxic activity of Thai medicinal plants for cancer treatment (2005) Songklanakarin J. Sci. Technol, 27, pp. 469-478; Myoungae, K., Cytotoxic activity of the extracts from Curcuma zedoaria (2003) J Toxicol Public Health, 19, pp. 293-296; Matthes, H.W., Cytotoxic components of Zingiber zerumbet, Curcuma zedoaria and C. domestica (1980) Phytochemistry, 19, pp. 2643-2650; Seo, W.-G., Suppressive effect of Zedoariae rhizoma on pulmonary metastasis of B16 melanoma cells (2005) J Ethnopharmacol, 101, pp. 249-257; Hong, C.H., Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells (2002) J Ethnopharmacol, 83, pp. 153-159; Miachir, J.I., Micropropagation and callogenesis of Curcuma zedoaria (2004) Sci Agric, 61, pp. 427-432; Cooper, E.L., Complementary and alternative medicine, when rigorous, can be science (2004) Evid Based Complement Alternat Med, 1, pp. 1-4; Müller, W.E.G., Traditional and modern biomedical prospecting: Part I-the history. Sustainable exploitation of biodiversity (sponges and invertebrates) in the Adriatic Sea at Rovinj (Croatia) (2004) Evid Based Complement Alternat Med, 1, pp. 71-82; Müller, W.E.G., Traditional and modern biomedical prospecting: Part II-the benefits. Approaches for a sustainable exploitation of biodiversity (secondary metabolites and biomaterials from sponges) (2004) Evid Based Complement Altern Med, 1, pp. 133-144; Patwardhan, B., Ayurveda and Traditional Chinese Medicine: A Comparative Overview (2005) Evid Based Complement Alternat Med, 2, pp. 465-473

PY - 2009

Y1 - 2009

N2 - Objectives Curcuma zedoaria Rosc is a perennial herb found in tropical countries, such as India, Japan and Thailand. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as diarrhoea, cancer, flatulence and dyspepsia. This study is an attempt to compile an up-to-date and comprehensive review of C. zedoaria that covers its traditional and folk medicinal uses, phytochemistry and pharmacology.

AB - Objectives Curcuma zedoaria Rosc is a perennial herb found in tropical countries, such as India, Japan and Thailand. Various parts of this plant are used in Ayurveda and other folk medicines for the treatment of different ailments such as diarrhoea, cancer, flatulence and dyspepsia. This study is an attempt to compile an up-to-date and comprehensive review of C. zedoaria that covers its traditional and folk medicinal uses, phytochemistry and pharmacology.

U2 - 10.1211/jpp/61.01.0003

DO - 10.1211/jpp/61.01.0003

M3 - Article

VL - 61

SP - 13

EP - 21

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 1

ER -