Cyclodextrins in pharmacy - An overview

N. Kanaka Durga Devi, A. Prameela Rani, M. Muneer Aved, K. SaiKumar, J. Kaushik, V. Sowjanya

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cyclodextrins are a group of compounds that enhances permeability through biological membrane, by which they act as permeation enhancers. In this present review article, the history, chemical structure, synthesis,physico-chemical properties,uses, complexation phenomenon, approaches for making inclusion complexes, and its charecterisation, advantages of inclusion complexes, mechanism of drug release, regulatory status, and applications of cyclodextrins have been explained neatly and legibly. The future prospects of CD and its derivatives are quite bright since they possess remarkably unique properties of forming inclusion complexes with drugs. An increasingly number of drugs being developed today have problem of poor solubility, bioavailability and permeability. CDs can serve as useful tools in the hands of pharmaceutical scientists for optimizing the drug delivery. © 2009, JGPT.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalJournal of Global Pharma Technology
Volume2
Issue number11
Publication statusPublished - 2010

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Cyclodextrins
Pharmaceutical Preparations
Permeability
Solubility
Biological Availability
History
Membranes

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Kanaka Durga Devi, N., Prameela Rani, A., Muneer Aved, M., SaiKumar, K., Kaushik, J., & Sowjanya, V. (2010). Cyclodextrins in pharmacy - An overview. Journal of Global Pharma Technology, 2(11), 1-10.
Kanaka Durga Devi, N. ; Prameela Rani, A. ; Muneer Aved, M. ; SaiKumar, K. ; Kaushik, J. ; Sowjanya, V. / Cyclodextrins in pharmacy - An overview. In: Journal of Global Pharma Technology. 2010 ; Vol. 2, No. 11. pp. 1-10.
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abstract = "Cyclodextrins are a group of compounds that enhances permeability through biological membrane, by which they act as permeation enhancers. In this present review article, the history, chemical structure, synthesis,physico-chemical properties,uses, complexation phenomenon, approaches for making inclusion complexes, and its charecterisation, advantages of inclusion complexes, mechanism of drug release, regulatory status, and applications of cyclodextrins have been explained neatly and legibly. The future prospects of CD and its derivatives are quite bright since they possess remarkably unique properties of forming inclusion complexes with drugs. An increasingly number of drugs being developed today have problem of poor solubility, bioavailability and permeability. CDs can serve as useful tools in the hands of pharmaceutical scientists for optimizing the drug delivery. {\circledC} 2009, JGPT.",
author = "{Kanaka Durga Devi}, N. and {Prameela Rani}, A. and {Muneer Aved}, M. and K. SaiKumar and J. Kaushik and V. Sowjanya",
note = "Export Date: 10 November 2017 Correspondence Address: Kanaka Durga Devi, N.; KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, India; email: nelluriss@rediffmail.com Chemicals/CAS: alpha cyclodextrin, 10016-20-3; beta cyclodextrin, 7585-39-9; cyclodextrin, 12619-70-4; estradiol, 50-28-2; gamma cyclodextrin, 17465-86-0; glyceryl trinitrate, 55-63-0; hydrocortisone, 50-23-7; itraconazole, 84625-61-6; metronidazole, 39322-38-8, 443-48-1; verapamil, 152-11-4, 52-53-9 References: Menuel, S., Joly, J.P., Courcot, B., Elysee, J., Ghermani, N.E., Marsua, A., Synthesis and inclusion ability of a Bis-β-cyclodextrin pseudo-cryptand towards Busulfan anticancer agent Tetrahedron, 67 (7), pp. 1706-1714; Becket, G., Schep, L.J., Tan, M.Y., Improvement of the in vitro dissolution of praziquantel by complexation with alpha-, beta- and gamma-cyclodextrins (1999) Int J Pharm, 179 (1), pp. 65-71; Biwer, A., Antranikian, G., Heinzle, E., Enzymatic production of cyclodextrins (2002) Applied Microbioloy Biotechnology, 59, pp. 609-617; Hall, D., Bloor, Tawarah, K., Kinetic and equilibrium studies associated with the formation of inclusion compounds involving N-butanol and N-pentanol in aqueous cyclodextrin solution (1986) J Chem. Soc. Faraday Trans, 82, pp. 2111-2121; Szejtli, J., Past,present, and future of cyclodextrin research (2004) Pure Appl.Chem, 76 (10), pp. 1825-1845; Baboota, S., Khanna, R., Agarwal, S.P.., (2003) Cyclodextrin in drug delivery systems: An update, , www.pharmainfo.net; Larrucea, E., Arellano, A., Santoyo, S., Ygartua, P., Study of the complexation behavior of tenoxicam with cyclodextrins in solution: Improved solubility and percutaneous permeability (2000) Drug Dev Ind Pharm, 27, pp. 245-252; Ammar, H.O., Salma, H.A., Ghorab, M., Formulation and biological evaluation of glimepiride-cyclodextrin-polymer systems (2006) Int J Pharm, 309, pp. 129-138; Cirri, M.F., Maestrelli, G., Corti, Simultaneous effect of cyclodextrin complexation, pH, and hydrophilic polymers on naproxen solubilization (2006) Jr. Pharm. Biomed Anal, 42, pp. 126-131; Belgamwar, V.S., Nakhat, P.D., Indurwade, N.H., Studies on inclusion complexes of furazolidone with cyclodextrins and their hydroxy propyl derivatives (2001) Indian Drugs, 38 (9), pp. 479-482; Marie, W., Maggie, A., Solid state studies of drug-cyclodextrin inclusion complexes in PEG-6000 prepared by new method (1999) Eur J Pharm Sci, 8, pp. 269-281; Toropainen, T.S., Velaga, T., Heikkila, Preparation of budesonide γ-cyclodextrin complexes in supercritical fluids with a novel SEDS method (2006) J Pharml Sci, 95 (10), pp. 2235-2245; Alka Pravin, Nagarsenker, M.S., Triamterene-β-cyclodextrin system: Prepartion, characterization and in vivo evaluation (2004) AAPS PharmSciTech, 5 (1), pp. 1-8; Reddy, N., Tasneem, R., Ramkarishna, K., β-cyclodextrin complexes of celecoxib: Molecularmodeling, characterization and dissolution studies (2004) AAPS Pharm Sci, 6 (1), pp. 1-9; David, C., Bibby, Nigel, M., Davies, Tucker, I.G., Improvement of water solubility and in-vitro dissolution rate of gliclazide by complexation with β-cyclodextrin (2000) Pharmaceutical Acta Helvetiae, 74, pp. 365-370; Carlos, V., Jacqueline, S., Mario, R., Cyclodextrins-The novel excipients: A review on pharmaceutical applications, Inclusion complex of antiviral drug acyclovir with cyclodextrin in aqueous solution and in solid phase (2000) Quimica nova, 23 (6), pp. 749-752; Nalluri, B.N., Chowdary, K.P.R., Ramana, K.V., Physicochemical characterization and dissolution properties of nimesulide-cyclodextrin binary systems (2002) Int.J. Pharm. Excip., p. 79; Stella, V.J., Roger, A.R., Cyclodextrins: Their future in drug formulation and delivery (1997) J.Pharm. Res, 14 (5), pp. 556-567; Rajewski, R.A., Stella, V.J., Pharmaceuti cal applications of cyclodextrins (1996) J. Pharm Sci., 85, pp. 1142-1145",
year = "2010",
language = "English",
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journal = "Journal of Global Pharma Technology",
issn = "0975-8542",
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}

Kanaka Durga Devi, N, Prameela Rani, A, Muneer Aved, M, SaiKumar, K, Kaushik, J & Sowjanya, V 2010, 'Cyclodextrins in pharmacy - An overview', Journal of Global Pharma Technology, vol. 2, no. 11, pp. 1-10.

Cyclodextrins in pharmacy - An overview. / Kanaka Durga Devi, N.; Prameela Rani, A.; Muneer Aved, M.; SaiKumar, K.; Kaushik, J.; Sowjanya, V.

In: Journal of Global Pharma Technology, Vol. 2, No. 11, 2010, p. 1-10.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cyclodextrins in pharmacy - An overview

AU - Kanaka Durga Devi, N.

AU - Prameela Rani, A.

AU - Muneer Aved, M.

AU - SaiKumar, K.

AU - Kaushik, J.

AU - Sowjanya, V.

N1 - Export Date: 10 November 2017 Correspondence Address: Kanaka Durga Devi, N.; KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, India; email: nelluriss@rediffmail.com Chemicals/CAS: alpha cyclodextrin, 10016-20-3; beta cyclodextrin, 7585-39-9; cyclodextrin, 12619-70-4; estradiol, 50-28-2; gamma cyclodextrin, 17465-86-0; glyceryl trinitrate, 55-63-0; hydrocortisone, 50-23-7; itraconazole, 84625-61-6; metronidazole, 39322-38-8, 443-48-1; verapamil, 152-11-4, 52-53-9 References: Menuel, S., Joly, J.P., Courcot, B., Elysee, J., Ghermani, N.E., Marsua, A., Synthesis and inclusion ability of a Bis-β-cyclodextrin pseudo-cryptand towards Busulfan anticancer agent Tetrahedron, 67 (7), pp. 1706-1714; Becket, G., Schep, L.J., Tan, M.Y., Improvement of the in vitro dissolution of praziquantel by complexation with alpha-, beta- and gamma-cyclodextrins (1999) Int J Pharm, 179 (1), pp. 65-71; Biwer, A., Antranikian, G., Heinzle, E., Enzymatic production of cyclodextrins (2002) Applied Microbioloy Biotechnology, 59, pp. 609-617; Hall, D., Bloor, Tawarah, K., Kinetic and equilibrium studies associated with the formation of inclusion compounds involving N-butanol and N-pentanol in aqueous cyclodextrin solution (1986) J Chem. Soc. Faraday Trans, 82, pp. 2111-2121; Szejtli, J., Past,present, and future of cyclodextrin research (2004) Pure Appl.Chem, 76 (10), pp. 1825-1845; Baboota, S., Khanna, R., Agarwal, S.P.., (2003) Cyclodextrin in drug delivery systems: An update, , www.pharmainfo.net; Larrucea, E., Arellano, A., Santoyo, S., Ygartua, P., Study of the complexation behavior of tenoxicam with cyclodextrins in solution: Improved solubility and percutaneous permeability (2000) Drug Dev Ind Pharm, 27, pp. 245-252; Ammar, H.O., Salma, H.A., Ghorab, M., Formulation and biological evaluation of glimepiride-cyclodextrin-polymer systems (2006) Int J Pharm, 309, pp. 129-138; Cirri, M.F., Maestrelli, G., Corti, Simultaneous effect of cyclodextrin complexation, pH, and hydrophilic polymers on naproxen solubilization (2006) Jr. Pharm. Biomed Anal, 42, pp. 126-131; Belgamwar, V.S., Nakhat, P.D., Indurwade, N.H., Studies on inclusion complexes of furazolidone with cyclodextrins and their hydroxy propyl derivatives (2001) Indian Drugs, 38 (9), pp. 479-482; Marie, W., Maggie, A., Solid state studies of drug-cyclodextrin inclusion complexes in PEG-6000 prepared by new method (1999) Eur J Pharm Sci, 8, pp. 269-281; Toropainen, T.S., Velaga, T., Heikkila, Preparation of budesonide γ-cyclodextrin complexes in supercritical fluids with a novel SEDS method (2006) J Pharml Sci, 95 (10), pp. 2235-2245; Alka Pravin, Nagarsenker, M.S., Triamterene-β-cyclodextrin system: Prepartion, characterization and in vivo evaluation (2004) AAPS PharmSciTech, 5 (1), pp. 1-8; Reddy, N., Tasneem, R., Ramkarishna, K., β-cyclodextrin complexes of celecoxib: Molecularmodeling, characterization and dissolution studies (2004) AAPS Pharm Sci, 6 (1), pp. 1-9; David, C., Bibby, Nigel, M., Davies, Tucker, I.G., Improvement of water solubility and in-vitro dissolution rate of gliclazide by complexation with β-cyclodextrin (2000) Pharmaceutical Acta Helvetiae, 74, pp. 365-370; Carlos, V., Jacqueline, S., Mario, R., Cyclodextrins-The novel excipients: A review on pharmaceutical applications, Inclusion complex of antiviral drug acyclovir with cyclodextrin in aqueous solution and in solid phase (2000) Quimica nova, 23 (6), pp. 749-752; Nalluri, B.N., Chowdary, K.P.R., Ramana, K.V., Physicochemical characterization and dissolution properties of nimesulide-cyclodextrin binary systems (2002) Int.J. Pharm. Excip., p. 79; Stella, V.J., Roger, A.R., Cyclodextrins: Their future in drug formulation and delivery (1997) J.Pharm. Res, 14 (5), pp. 556-567; Rajewski, R.A., Stella, V.J., Pharmaceuti cal applications of cyclodextrins (1996) J. Pharm Sci., 85, pp. 1142-1145

PY - 2010

Y1 - 2010

N2 - Cyclodextrins are a group of compounds that enhances permeability through biological membrane, by which they act as permeation enhancers. In this present review article, the history, chemical structure, synthesis,physico-chemical properties,uses, complexation phenomenon, approaches for making inclusion complexes, and its charecterisation, advantages of inclusion complexes, mechanism of drug release, regulatory status, and applications of cyclodextrins have been explained neatly and legibly. The future prospects of CD and its derivatives are quite bright since they possess remarkably unique properties of forming inclusion complexes with drugs. An increasingly number of drugs being developed today have problem of poor solubility, bioavailability and permeability. CDs can serve as useful tools in the hands of pharmaceutical scientists for optimizing the drug delivery. © 2009, JGPT.

AB - Cyclodextrins are a group of compounds that enhances permeability through biological membrane, by which they act as permeation enhancers. In this present review article, the history, chemical structure, synthesis,physico-chemical properties,uses, complexation phenomenon, approaches for making inclusion complexes, and its charecterisation, advantages of inclusion complexes, mechanism of drug release, regulatory status, and applications of cyclodextrins have been explained neatly and legibly. The future prospects of CD and its derivatives are quite bright since they possess remarkably unique properties of forming inclusion complexes with drugs. An increasingly number of drugs being developed today have problem of poor solubility, bioavailability and permeability. CDs can serve as useful tools in the hands of pharmaceutical scientists for optimizing the drug delivery. © 2009, JGPT.

M3 - Article

VL - 2

SP - 1

EP - 10

JO - Journal of Global Pharma Technology

JF - Journal of Global Pharma Technology

SN - 0975-8542

IS - 11

ER -

Kanaka Durga Devi N, Prameela Rani A, Muneer Aved M, SaiKumar K, Kaushik J, Sowjanya V. Cyclodextrins in pharmacy - An overview. Journal of Global Pharma Technology. 2010;2(11):1-10.