TY - JOUR
T1 - Cyclodextrins in pharmacy - An overview
AU - Kanaka Durga Devi, N.
AU - Prameela Rani, A.
AU - Muneer Aved, M.
AU - SaiKumar, K.
AU - Kaushik, J.
AU - Sowjanya, V.
N1 - Export Date: 10 November 2017
Correspondence Address: Kanaka Durga Devi, N.; KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, India; email: nelluriss@rediffmail.com
Chemicals/CAS: alpha cyclodextrin, 10016-20-3; beta cyclodextrin, 7585-39-9; cyclodextrin, 12619-70-4; estradiol, 50-28-2; gamma cyclodextrin, 17465-86-0; glyceryl trinitrate, 55-63-0; hydrocortisone, 50-23-7; itraconazole, 84625-61-6; metronidazole, 39322-38-8, 443-48-1; verapamil, 152-11-4, 52-53-9
References: Menuel, S., Joly, J.P., Courcot, B., Elysee, J., Ghermani, N.E., Marsua, A., Synthesis and inclusion ability of a Bis-β-cyclodextrin pseudo-cryptand towards Busulfan anticancer agent Tetrahedron, 67 (7), pp. 1706-1714; Becket, G., Schep, L.J., Tan, M.Y., Improvement of the in vitro dissolution of praziquantel by complexation with alpha-, beta- and gamma-cyclodextrins (1999) Int J Pharm, 179 (1), pp. 65-71; Biwer, A., Antranikian, G., Heinzle, E., Enzymatic production of cyclodextrins (2002) Applied Microbioloy Biotechnology, 59, pp. 609-617; Hall, D., Bloor, Tawarah, K., Kinetic and equilibrium studies associated with the formation of inclusion compounds involving N-butanol and N-pentanol in aqueous cyclodextrin solution (1986) J Chem. Soc. Faraday Trans, 82, pp. 2111-2121; Szejtli, J., Past,present, and future of cyclodextrin research (2004) Pure Appl.Chem, 76 (10), pp. 1825-1845; Baboota, S., Khanna, R., Agarwal, S.P.., (2003) Cyclodextrin in drug delivery systems: An update, , www.pharmainfo.net; Larrucea, E., Arellano, A., Santoyo, S., Ygartua, P., Study of the complexation behavior of tenoxicam with cyclodextrins in solution: Improved solubility and percutaneous permeability (2000) Drug Dev Ind Pharm, 27, pp. 245-252; Ammar, H.O., Salma, H.A., Ghorab, M., Formulation and biological evaluation of glimepiride-cyclodextrin-polymer systems (2006) Int J Pharm, 309, pp. 129-138; Cirri, M.F., Maestrelli, G., Corti, Simultaneous effect of cyclodextrin complexation, pH, and hydrophilic polymers on naproxen solubilization (2006) Jr. Pharm. Biomed Anal, 42, pp. 126-131; Belgamwar, V.S., Nakhat, P.D., Indurwade, N.H., Studies on inclusion complexes of furazolidone with cyclodextrins and their hydroxy propyl derivatives (2001) Indian Drugs, 38 (9), pp. 479-482; Marie, W., Maggie, A., Solid state studies of drug-cyclodextrin inclusion complexes in PEG-6000 prepared by new method (1999) Eur J Pharm Sci, 8, pp. 269-281; Toropainen, T.S., Velaga, T., Heikkila, Preparation of budesonide γ-cyclodextrin complexes in supercritical fluids with a novel SEDS method (2006) J Pharml Sci, 95 (10), pp. 2235-2245; Alka Pravin, Nagarsenker, M.S., Triamterene-β-cyclodextrin system: Prepartion, characterization and in vivo evaluation (2004) AAPS PharmSciTech, 5 (1), pp. 1-8; Reddy, N., Tasneem, R., Ramkarishna, K., β-cyclodextrin complexes of celecoxib: Molecularmodeling, characterization and dissolution studies (2004) AAPS Pharm Sci, 6 (1), pp. 1-9; David, C., Bibby, Nigel, M., Davies, Tucker, I.G., Improvement of water solubility and in-vitro dissolution rate of gliclazide by complexation with β-cyclodextrin (2000) Pharmaceutical Acta Helvetiae, 74, pp. 365-370; Carlos, V., Jacqueline, S., Mario, R., Cyclodextrins-The novel excipients: A review on pharmaceutical applications, Inclusion complex of antiviral drug acyclovir with cyclodextrin in aqueous solution and in solid phase (2000) Quimica nova, 23 (6), pp. 749-752; Nalluri, B.N., Chowdary, K.P.R., Ramana, K.V., Physicochemical characterization and dissolution properties of nimesulide-cyclodextrin binary systems (2002) Int.J. Pharm. Excip., p. 79; Stella, V.J., Roger, A.R., Cyclodextrins: Their future in drug formulation and delivery (1997) J.Pharm. Res, 14 (5), pp. 556-567; Rajewski, R.A., Stella, V.J., Pharmaceuti cal applications of cyclodextrins (1996) J. Pharm Sci., 85, pp. 1142-1145
PY - 2010
Y1 - 2010
N2 - Cyclodextrins are a group of compounds that enhances permeability through biological membrane, by which they act as permeation enhancers. In this present review article, the history, chemical structure, synthesis,physico-chemical properties,uses, complexation phenomenon, approaches for making inclusion complexes, and its charecterisation, advantages of inclusion complexes, mechanism of drug release, regulatory status, and applications of cyclodextrins have been explained neatly and legibly. The future prospects of CD and its derivatives are quite bright since they possess remarkably unique properties of forming inclusion complexes with drugs. An increasingly number of drugs being developed today have problem of poor solubility, bioavailability and permeability. CDs can serve as useful tools in the hands of pharmaceutical scientists for optimizing the drug delivery. © 2009, JGPT.
AB - Cyclodextrins are a group of compounds that enhances permeability through biological membrane, by which they act as permeation enhancers. In this present review article, the history, chemical structure, synthesis,physico-chemical properties,uses, complexation phenomenon, approaches for making inclusion complexes, and its charecterisation, advantages of inclusion complexes, mechanism of drug release, regulatory status, and applications of cyclodextrins have been explained neatly and legibly. The future prospects of CD and its derivatives are quite bright since they possess remarkably unique properties of forming inclusion complexes with drugs. An increasingly number of drugs being developed today have problem of poor solubility, bioavailability and permeability. CDs can serve as useful tools in the hands of pharmaceutical scientists for optimizing the drug delivery. © 2009, JGPT.
M3 - Article
SN - 0975-8542
VL - 2
SP - 1
EP - 10
JO - Journal of Global Pharma Technology
JF - Journal of Global Pharma Technology
IS - 11
ER -