Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma.

Addala Lakshmi, Sadhnani Muralidhar, Chennaboina Kalyan Kumar, Addala Pavan Kumar, Pentapati Kalyana Chakravarthy, Vasala Anjaneyulu, Jamil Kaiser

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cyclooxygenase-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins, and has critical role in the progression of several malignancies, including oral squamous cell carcinoma. We designed a case-control study to evaluate the susceptibility of the functional -765G>C genetic variation in oral squamous cell carcinoma patients. Polymerase chain reaction-based restriction fragment length polymorphism analysis was used to determine the polymorphism in oral squamous cell carcinoma (n = 150) patients and healthy controls (n = 150). The genotype frequencies of cyclooxygenase-2 765G>G, 765G>C, and 765C>C were 73.3%, 18.66%, and 8.0% in the cancer patients, and 94.66%, 4% and 1.3% in the controls, respectively. The cyclooxygenase-2 GC and CC genotypes were significantly associated (P = 0.0003 and P = 0.01, respectively) with oral squamous cell carcinoma patients, when compared to the controls. The 765G>C genotypes were statistically significant, with habitual tobacco chewing and alcohol consumption + smoking (P = 0.05). This study highlights the genetic variant that might play a role in mediating susceptibility to oral squamous cell carcinoma in this population.

Original languageEnglish
Pages (from-to)182-188
Number of pages7
JournalJournal of investigative and clinical dentistry
Volume3
Issue number3
Publication statusPublished - 01-08-2012

Fingerprint

Cyclooxygenase 2
Squamous Cell Carcinoma
Genotype
Tobacco Use
Arachidonic Acid
Alcohol Drinking
Restriction Fragment Length Polymorphisms
Prostaglandins
Case-Control Studies
Neoplasms
Smoking
Polymerase Chain Reaction
Enzymes
Population

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lakshmi, Addala ; Muralidhar, Sadhnani ; Kalyan Kumar, Chennaboina ; Pavan Kumar, Addala ; Kalyana Chakravarthy, Pentapati ; Anjaneyulu, Vasala ; Kaiser, Jamil. / Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma. In: Journal of investigative and clinical dentistry. 2012 ; Vol. 3, No. 3. pp. 182-188.
@article{6f549a625a384bd69ab3a60fa7d89f23,
title = "Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma.",
abstract = "Cyclooxygenase-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins, and has critical role in the progression of several malignancies, including oral squamous cell carcinoma. We designed a case-control study to evaluate the susceptibility of the functional -765G>C genetic variation in oral squamous cell carcinoma patients. Polymerase chain reaction-based restriction fragment length polymorphism analysis was used to determine the polymorphism in oral squamous cell carcinoma (n = 150) patients and healthy controls (n = 150). The genotype frequencies of cyclooxygenase-2 765G>G, 765G>C, and 765C>C were 73.3{\%}, 18.66{\%}, and 8.0{\%} in the cancer patients, and 94.66{\%}, 4{\%} and 1.3{\%} in the controls, respectively. The cyclooxygenase-2 GC and CC genotypes were significantly associated (P = 0.0003 and P = 0.01, respectively) with oral squamous cell carcinoma patients, when compared to the controls. The 765G>C genotypes were statistically significant, with habitual tobacco chewing and alcohol consumption + smoking (P = 0.05). This study highlights the genetic variant that might play a role in mediating susceptibility to oral squamous cell carcinoma in this population.",
author = "Addala Lakshmi and Sadhnani Muralidhar and {Kalyan Kumar}, Chennaboina and {Pavan Kumar}, Addala and {Kalyana Chakravarthy}, Pentapati and Vasala Anjaneyulu and Jamil Kaiser",
year = "2012",
month = "8",
day = "1",
language = "English",
volume = "3",
pages = "182--188",
journal = "Journal of investigative and clinical dentistry",
issn = "2041-1618",
publisher = "Wiley-Blackwell",
number = "3",

}

Lakshmi, A, Muralidhar, S, Kalyan Kumar, C, Pavan Kumar, A, Kalyana Chakravarthy, P, Anjaneyulu, V & Kaiser, J 2012, 'Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma.', Journal of investigative and clinical dentistry, vol. 3, no. 3, pp. 182-188.

Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma. / Lakshmi, Addala; Muralidhar, Sadhnani; Kalyan Kumar, Chennaboina; Pavan Kumar, Addala; Kalyana Chakravarthy, Pentapati; Anjaneyulu, Vasala; Kaiser, Jamil.

In: Journal of investigative and clinical dentistry, Vol. 3, No. 3, 01.08.2012, p. 182-188.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma.

AU - Lakshmi, Addala

AU - Muralidhar, Sadhnani

AU - Kalyan Kumar, Chennaboina

AU - Pavan Kumar, Addala

AU - Kalyana Chakravarthy, Pentapati

AU - Anjaneyulu, Vasala

AU - Kaiser, Jamil

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Cyclooxygenase-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins, and has critical role in the progression of several malignancies, including oral squamous cell carcinoma. We designed a case-control study to evaluate the susceptibility of the functional -765G>C genetic variation in oral squamous cell carcinoma patients. Polymerase chain reaction-based restriction fragment length polymorphism analysis was used to determine the polymorphism in oral squamous cell carcinoma (n = 150) patients and healthy controls (n = 150). The genotype frequencies of cyclooxygenase-2 765G>G, 765G>C, and 765C>C were 73.3%, 18.66%, and 8.0% in the cancer patients, and 94.66%, 4% and 1.3% in the controls, respectively. The cyclooxygenase-2 GC and CC genotypes were significantly associated (P = 0.0003 and P = 0.01, respectively) with oral squamous cell carcinoma patients, when compared to the controls. The 765G>C genotypes were statistically significant, with habitual tobacco chewing and alcohol consumption + smoking (P = 0.05). This study highlights the genetic variant that might play a role in mediating susceptibility to oral squamous cell carcinoma in this population.

AB - Cyclooxygenase-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins, and has critical role in the progression of several malignancies, including oral squamous cell carcinoma. We designed a case-control study to evaluate the susceptibility of the functional -765G>C genetic variation in oral squamous cell carcinoma patients. Polymerase chain reaction-based restriction fragment length polymorphism analysis was used to determine the polymorphism in oral squamous cell carcinoma (n = 150) patients and healthy controls (n = 150). The genotype frequencies of cyclooxygenase-2 765G>G, 765G>C, and 765C>C were 73.3%, 18.66%, and 8.0% in the cancer patients, and 94.66%, 4% and 1.3% in the controls, respectively. The cyclooxygenase-2 GC and CC genotypes were significantly associated (P = 0.0003 and P = 0.01, respectively) with oral squamous cell carcinoma patients, when compared to the controls. The 765G>C genotypes were statistically significant, with habitual tobacco chewing and alcohol consumption + smoking (P = 0.05). This study highlights the genetic variant that might play a role in mediating susceptibility to oral squamous cell carcinoma in this population.

UR - http://www.scopus.com/inward/record.url?scp=84876434498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876434498&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 182

EP - 188

JO - Journal of investigative and clinical dentistry

JF - Journal of investigative and clinical dentistry

SN - 2041-1618

IS - 3

ER -