Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma.

Addala Lakshmi, Sadhnani Muralidhar, Chennaboina Kalyan Kumar, Addala Pavan Kumar, Pentapati Kalyana Chakravarthy, Vasala Anjaneyulu, Jamil Kaiser

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cyclooxygenase-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins, and has critical role in the progression of several malignancies, including oral squamous cell carcinoma. We designed a case-control study to evaluate the susceptibility of the functional -765G>C genetic variation in oral squamous cell carcinoma patients. Polymerase chain reaction-based restriction fragment length polymorphism analysis was used to determine the polymorphism in oral squamous cell carcinoma (n = 150) patients and healthy controls (n = 150). The genotype frequencies of cyclooxygenase-2 765G>G, 765G>C, and 765C>C were 73.3%, 18.66%, and 8.0% in the cancer patients, and 94.66%, 4% and 1.3% in the controls, respectively. The cyclooxygenase-2 GC and CC genotypes were significantly associated (P = 0.0003 and P = 0.01, respectively) with oral squamous cell carcinoma patients, when compared to the controls. The 765G>C genotypes were statistically significant, with habitual tobacco chewing and alcohol consumption + smoking (P = 0.05). This study highlights the genetic variant that might play a role in mediating susceptibility to oral squamous cell carcinoma in this population.

Original languageEnglish
Pages (from-to)182-188
Number of pages7
JournalJournal of investigative and clinical dentistry
Volume3
Issue number3
Publication statusPublished - 01-08-2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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