Cyclophosphamide and doxorubicin induced melanonychia: A case report

Vivek Bhanubhai Prajapati, Sharath Madhyastha, Raviraj Acharya, Vinaya Gopalaswamy, Akhila Doddamani

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Chemotherapeutic agents may rarely cause discoloration and hyperpigmentation of the nails. We present a patient who developed blackish discoloration of nails also referred as melanonychia during six cycles of R-CHOP chemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) for the treatment of Non Hodgkin Lymphoma (NHL) follicular type. The patient developed blackish brown discoloration in all the nails. As suggested by previous literature evidence the melanonychia could be associated with cyclophosphamide and doxorubicin. According to the Naranjo causality assessment scale, we established that there was a ‘probable’ association of nail discoloration with the drug.

Original languageEnglish
Pages (from-to)OD04-OD05
JournalJournal of Clinical and Diagnostic Research
Volume11
Issue number1
DOIs
Publication statusPublished - 01-01-2017

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Clinical Biochemistry

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