Cyclophosphamide induced fatal cytopenia

A case of paraquat poisoning

Ajit Singh, V. Rajesh, Sonal Sekhar, Barakur Ananthakrishna Shastri, Kavitha Saravu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Paraquat is an effective herbicide widely used in India, but is highly toxic on human exposure. Cyclophosphamide is used as pulse therapy in combination with methylprednisolone for paraquat poisoning management. Neutropenia and thrombocytopenia are the main side effects which may occur with cyclophosphamide in cancer treatment due to bone marrow suppression. Hereby we report a rare case of cyclophosphamide-induced fatal cytopenia in a patient with paraquat poisoning. This is a case of 24 y old male who came to the emergency department of our hospital with a history of alleged consumption of 50 ml of paraquat liquid. On admission, he complained of pain and burning sensation in the throat and retrosternal region. Different treatment modalities, namely, pulse therapy with cyclophosphamide and methylprednisolone; and hemoperfusion were used to manage patient’s condition. Within few days, the patient developed severe neutropenia and thrombocytopenia. Despite several blood transfusions, the patient expired due to fatal manifestations of cytopenia.

Original languageEnglish
Pages (from-to)296-297
Number of pages2
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume8
Issue number10
DOIs
Publication statusPublished - 2016

Fingerprint

Paraquat
Cyclophosphamide
Poisoning
Methylprednisolone
Neutropenia
Thrombocytopenia
Hemoperfusion
Poisons
Herbicides
Therapeutics
Pharynx
Blood Transfusion
Hospital Emergency Service
India
Bone Marrow
Pain
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

@article{252d87c16db249fdb8a0b9f7aa460283,
title = "Cyclophosphamide induced fatal cytopenia: A case of paraquat poisoning",
abstract = "Paraquat is an effective herbicide widely used in India, but is highly toxic on human exposure. Cyclophosphamide is used as pulse therapy in combination with methylprednisolone for paraquat poisoning management. Neutropenia and thrombocytopenia are the main side effects which may occur with cyclophosphamide in cancer treatment due to bone marrow suppression. Hereby we report a rare case of cyclophosphamide-induced fatal cytopenia in a patient with paraquat poisoning. This is a case of 24 y old male who came to the emergency department of our hospital with a history of alleged consumption of 50 ml of paraquat liquid. On admission, he complained of pain and burning sensation in the throat and retrosternal region. Different treatment modalities, namely, pulse therapy with cyclophosphamide and methylprednisolone; and hemoperfusion were used to manage patient’s condition. Within few days, the patient developed severe neutropenia and thrombocytopenia. Despite several blood transfusions, the patient expired due to fatal manifestations of cytopenia.",
author = "Ajit Singh and V. Rajesh and Sonal Sekhar and Shastri, {Barakur Ananthakrishna} and Kavitha Saravu",
year = "2016",
doi = "10.22159/ijpps.2016v8i10.12253",
language = "English",
volume = "8",
pages = "296--297",
journal = "International Journal of Pharmacy and Pharmaceutical Sciences",
issn = "0975-1491",
publisher = "IJPPS",
number = "10",

}

Cyclophosphamide induced fatal cytopenia : A case of paraquat poisoning. / Singh, Ajit; Rajesh, V.; Sekhar, Sonal; Shastri, Barakur Ananthakrishna; Saravu, Kavitha.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 8, No. 10, 2016, p. 296-297.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cyclophosphamide induced fatal cytopenia

T2 - A case of paraquat poisoning

AU - Singh, Ajit

AU - Rajesh, V.

AU - Sekhar, Sonal

AU - Shastri, Barakur Ananthakrishna

AU - Saravu, Kavitha

PY - 2016

Y1 - 2016

N2 - Paraquat is an effective herbicide widely used in India, but is highly toxic on human exposure. Cyclophosphamide is used as pulse therapy in combination with methylprednisolone for paraquat poisoning management. Neutropenia and thrombocytopenia are the main side effects which may occur with cyclophosphamide in cancer treatment due to bone marrow suppression. Hereby we report a rare case of cyclophosphamide-induced fatal cytopenia in a patient with paraquat poisoning. This is a case of 24 y old male who came to the emergency department of our hospital with a history of alleged consumption of 50 ml of paraquat liquid. On admission, he complained of pain and burning sensation in the throat and retrosternal region. Different treatment modalities, namely, pulse therapy with cyclophosphamide and methylprednisolone; and hemoperfusion were used to manage patient’s condition. Within few days, the patient developed severe neutropenia and thrombocytopenia. Despite several blood transfusions, the patient expired due to fatal manifestations of cytopenia.

AB - Paraquat is an effective herbicide widely used in India, but is highly toxic on human exposure. Cyclophosphamide is used as pulse therapy in combination with methylprednisolone for paraquat poisoning management. Neutropenia and thrombocytopenia are the main side effects which may occur with cyclophosphamide in cancer treatment due to bone marrow suppression. Hereby we report a rare case of cyclophosphamide-induced fatal cytopenia in a patient with paraquat poisoning. This is a case of 24 y old male who came to the emergency department of our hospital with a history of alleged consumption of 50 ml of paraquat liquid. On admission, he complained of pain and burning sensation in the throat and retrosternal region. Different treatment modalities, namely, pulse therapy with cyclophosphamide and methylprednisolone; and hemoperfusion were used to manage patient’s condition. Within few days, the patient developed severe neutropenia and thrombocytopenia. Despite several blood transfusions, the patient expired due to fatal manifestations of cytopenia.

UR - http://www.scopus.com/inward/record.url?scp=85000350869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85000350869&partnerID=8YFLogxK

U2 - 10.22159/ijpps.2016v8i10.12253

DO - 10.22159/ijpps.2016v8i10.12253

M3 - Article

VL - 8

SP - 296

EP - 297

JO - International Journal of Pharmacy and Pharmaceutical Sciences

JF - International Journal of Pharmacy and Pharmaceutical Sciences

SN - 0975-1491

IS - 10

ER -