Cystone, an ayurvedic herbal drug imparts protection to the mice against the lethal effects of γ-radiation

A preliminary study

Ganesh Chandra Jagetia, Manjeshwar Shrinath Baliga

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The effect of 5, 10, 20, 40, 60, 80, 100, 120, and 160 mg/kg body weight (b.wt.) of aqueous extract of cystone (an ayurvedic herbal medicine) administered intraperitoneally was studied on the radiation-induced mortality in mice exposed to 10 Gy of γ-radiation. Treatment of mice with different doses of cystone, consecutively for five days before irradiation, delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irradiated controls. The pretreatment of mice with different doses of cystone before exposure to 10 Gy of γ-radiation resulted in a dose-dependent elevation in the survival up to 40 mg/kg b. wt., where the highest number of survival (55.55%) was observed by 30 days post irradiation, when compared with the 10 Gy irradiated control (6.66%). Thereafter, the number of survivors declined and reached a nadir at 160 mg/kg, where no survivors could be observed. The optimum protection against irradiation was observed for 40 mg/kg cystone, where the highest number of survivors were reported by 30 days post irradiation and it was 8.34-fold greater than that of the irradiated control group.

Original languageEnglish
Pages (from-to)332-336
Number of pages5
JournalNahrung - Food
Volume46
Issue number5
DOIs
Publication statusPublished - 01-10-2002
Externally publishedYes

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herbal medicines
Radiation Effects
irradiation
Survivors
Radiation Dosage
mice
Pharmaceutical Preparations
dosage
Ayurvedic Medicine
radiation injury
Radiation Injuries
Survival
Mortality
Herbal Medicine
pretreatment
Body Weight
Radiation
Control Groups
body weight
cystone

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

Jagetia, Ganesh Chandra ; Baliga, Manjeshwar Shrinath. / Cystone, an ayurvedic herbal drug imparts protection to the mice against the lethal effects of γ-radiation : A preliminary study. In: Nahrung - Food. 2002 ; Vol. 46, No. 5. pp. 332-336.
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Cystone, an ayurvedic herbal drug imparts protection to the mice against the lethal effects of γ-radiation : A preliminary study. / Jagetia, Ganesh Chandra; Baliga, Manjeshwar Shrinath.

In: Nahrung - Food, Vol. 46, No. 5, 01.10.2002, p. 332-336.

Research output: Contribution to journalArticle

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