Dehydrozingerone and its analogues as inhibitors of nonenzymatic lipid peroxidation

D.V. Rajakumar, M.N.A. Rao

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The antioxidant property of dehydrozingerone and its analogs were investigated in the ferric-ascorbate induced lipid peroxidation model in rat brain homogenate. All the non phenolic compounds were either inactive or less active, while phenolic compounds with substitution at both meta positions were found to be more active than dehydrozingerone. Based on their IC 50 values several of these compounds are more potent than vitamin E and hence may be of potential use in various diseases caused by oxidant stress.
Original languageUndefined/Unknown
Pages (from-to)516-519
Number of pages4
JournalPharmazie
Volume49
Issue number7
Publication statusPublished - 1994
Externally publishedYes

Cite this

Rajakumar, D. V., & Rao, M. N. A. (1994). Dehydrozingerone and its analogues as inhibitors of nonenzymatic lipid peroxidation. Pharmazie, 49(7), 516-519.
Rajakumar, D.V. ; Rao, M.N.A. / Dehydrozingerone and its analogues as inhibitors of nonenzymatic lipid peroxidation. In: Pharmazie. 1994 ; Vol. 49, No. 7. pp. 516-519.
@article{0ef93f4949b3441ea7300cc41bada6d6,
title = "Dehydrozingerone and its analogues as inhibitors of nonenzymatic lipid peroxidation",
abstract = "The antioxidant property of dehydrozingerone and its analogs were investigated in the ferric-ascorbate induced lipid peroxidation model in rat brain homogenate. All the non phenolic compounds were either inactive or less active, while phenolic compounds with substitution at both meta positions were found to be more active than dehydrozingerone. Based on their IC 50 values several of these compounds are more potent than vitamin E and hence may be of potential use in various diseases caused by oxidant stress.",
author = "D.V. Rajakumar and M.N.A. Rao",
note = "cited By 16",
year = "1994",
language = "Undefined/Unknown",
volume = "49",
pages = "516--519",
journal = "Die Pharmazie",
issn = "0031-7144",
publisher = "Govi-Verlag Pharmazeutischer Verlag GmbH",
number = "7",

}

Rajakumar, DV & Rao, MNA 1994, 'Dehydrozingerone and its analogues as inhibitors of nonenzymatic lipid peroxidation', Pharmazie, vol. 49, no. 7, pp. 516-519.

Dehydrozingerone and its analogues as inhibitors of nonenzymatic lipid peroxidation. / Rajakumar, D.V.; Rao, M.N.A.

In: Pharmazie, Vol. 49, No. 7, 1994, p. 516-519.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dehydrozingerone and its analogues as inhibitors of nonenzymatic lipid peroxidation

AU - Rajakumar, D.V.

AU - Rao, M.N.A.

N1 - cited By 16

PY - 1994

Y1 - 1994

N2 - The antioxidant property of dehydrozingerone and its analogs were investigated in the ferric-ascorbate induced lipid peroxidation model in rat brain homogenate. All the non phenolic compounds were either inactive or less active, while phenolic compounds with substitution at both meta positions were found to be more active than dehydrozingerone. Based on their IC 50 values several of these compounds are more potent than vitamin E and hence may be of potential use in various diseases caused by oxidant stress.

AB - The antioxidant property of dehydrozingerone and its analogs were investigated in the ferric-ascorbate induced lipid peroxidation model in rat brain homogenate. All the non phenolic compounds were either inactive or less active, while phenolic compounds with substitution at both meta positions were found to be more active than dehydrozingerone. Based on their IC 50 values several of these compounds are more potent than vitamin E and hence may be of potential use in various diseases caused by oxidant stress.

M3 - Article

VL - 49

SP - 516

EP - 519

JO - Die Pharmazie

JF - Die Pharmazie

SN - 0031-7144

IS - 7

ER -