Delving deeper into dermal and transdermal drug delivery

Factors and mechanisms associated with nanocarrier-mediated strategies

Jyothsna Manikkath, T. K. Sumathy, Aparna Manikkath, Srinivas Mutalik

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Background: Advances in material science and particle engineering have led to the development of a rapidly growing number of nanoparticulate carriers for drug and gene delivery. These carriers are increasingly being investigated in dermal and transdermal routes of drug administration. Objective: To critically examine and summarize the primary factors and mechanisms involved in nanocarrier-mediated dermal and transdermal delivery of drugs. Method: Thorough literature search was undertaken, spanning the early development of nanocarrier-mediated dermal and transdermal drug delivery approaches, to the current state of the art, using online search tools. Results: Physicochemical, formulation, experimental and morphological factors, such as, material of construction or type of nanoparticle (NP), surface chemistry, particle size, particle shape, surface charge, dispersion medium, duration of exposure of skin to NPs, combination of NPs with physical agents, and aspects related to skin were identified and discussed. Conclusion: The key factors and mechanisms which influence NPs-skin interactions in dermal and transdermal drug delivery are discussed in this article in-line with the current advances in the field.

Original languageEnglish
Pages (from-to)3210-3222
Number of pages13
JournalCurrent Pharmaceutical Design
Volume24
Issue number27
DOIs
Publication statusPublished - 01-01-2018

Fingerprint

Skin
Pharmaceutical Preparations
Drug Administration Routes
Drug Carriers
Particle Size
Nanoparticles
Genes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

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title = "Delving deeper into dermal and transdermal drug delivery: Factors and mechanisms associated with nanocarrier-mediated strategies",
abstract = "Background: Advances in material science and particle engineering have led to the development of a rapidly growing number of nanoparticulate carriers for drug and gene delivery. These carriers are increasingly being investigated in dermal and transdermal routes of drug administration. Objective: To critically examine and summarize the primary factors and mechanisms involved in nanocarrier-mediated dermal and transdermal delivery of drugs. Method: Thorough literature search was undertaken, spanning the early development of nanocarrier-mediated dermal and transdermal drug delivery approaches, to the current state of the art, using online search tools. Results: Physicochemical, formulation, experimental and morphological factors, such as, material of construction or type of nanoparticle (NP), surface chemistry, particle size, particle shape, surface charge, dispersion medium, duration of exposure of skin to NPs, combination of NPs with physical agents, and aspects related to skin were identified and discussed. Conclusion: The key factors and mechanisms which influence NPs-skin interactions in dermal and transdermal drug delivery are discussed in this article in-line with the current advances in the field.",
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Delving deeper into dermal and transdermal drug delivery : Factors and mechanisms associated with nanocarrier-mediated strategies. / Manikkath, Jyothsna; Sumathy, T. K.; Manikkath, Aparna; Mutalik, Srinivas.

In: Current Pharmaceutical Design, Vol. 24, No. 27, 01.01.2018, p. 3210-3222.

Research output: Contribution to journalReview article

TY - JOUR

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T2 - Factors and mechanisms associated with nanocarrier-mediated strategies

AU - Manikkath, Jyothsna

AU - Sumathy, T. K.

AU - Manikkath, Aparna

AU - Mutalik, Srinivas

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N2 - Background: Advances in material science and particle engineering have led to the development of a rapidly growing number of nanoparticulate carriers for drug and gene delivery. These carriers are increasingly being investigated in dermal and transdermal routes of drug administration. Objective: To critically examine and summarize the primary factors and mechanisms involved in nanocarrier-mediated dermal and transdermal delivery of drugs. Method: Thorough literature search was undertaken, spanning the early development of nanocarrier-mediated dermal and transdermal drug delivery approaches, to the current state of the art, using online search tools. Results: Physicochemical, formulation, experimental and morphological factors, such as, material of construction or type of nanoparticle (NP), surface chemistry, particle size, particle shape, surface charge, dispersion medium, duration of exposure of skin to NPs, combination of NPs with physical agents, and aspects related to skin were identified and discussed. Conclusion: The key factors and mechanisms which influence NPs-skin interactions in dermal and transdermal drug delivery are discussed in this article in-line with the current advances in the field.

AB - Background: Advances in material science and particle engineering have led to the development of a rapidly growing number of nanoparticulate carriers for drug and gene delivery. These carriers are increasingly being investigated in dermal and transdermal routes of drug administration. Objective: To critically examine and summarize the primary factors and mechanisms involved in nanocarrier-mediated dermal and transdermal delivery of drugs. Method: Thorough literature search was undertaken, spanning the early development of nanocarrier-mediated dermal and transdermal drug delivery approaches, to the current state of the art, using online search tools. Results: Physicochemical, formulation, experimental and morphological factors, such as, material of construction or type of nanoparticle (NP), surface chemistry, particle size, particle shape, surface charge, dispersion medium, duration of exposure of skin to NPs, combination of NPs with physical agents, and aspects related to skin were identified and discussed. Conclusion: The key factors and mechanisms which influence NPs-skin interactions in dermal and transdermal drug delivery are discussed in this article in-line with the current advances in the field.

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