Design and development of thiolated graphene oxide nanosheets for brain tumor targeting

Ajinkya N. Nikam, Mahesh P. More, Abhijeet P. Pandey, Pravin O. Patil, Ashwini G. Patil, Prashant K. Deshmukh

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present investigation emphasizes on synthesis and characterization of thiol functionalized reduced graphene oxide (TrGO) as a novel platform for loading of anticancer drug methotrexate (TrGO-MTX), through amide bonding. Thiolation of graphene oxide (GO) was achieved by transesterification process. The introduction of sulfur containing chemical groups and the partial reduction of GO to TrGO were proven by analytical techniques. Thiol content was found to be 6.98 mM by Ellman’s method in a quantitative manner. Furthermore, antineoplastic action of TrGO-MTX against human glioblastoma astrocytom U-373 MG cell line was studied, wherein TrGO-MTX demonstrated significant inhibition rate as compared with pure MTX.

Original languageEnglish
JournalInternational Journal of Polymeric Materials and Polymeric Biomaterials
DOIs
Publication statusAccepted/In press - 01-01-2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemical Engineering(all)
  • Polymers and Plastics

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