The present investigation emphasizes on synthesis and characterization of thiol functionalized reduced graphene oxide (TrGO) as a novel platform for loading of anticancer drug methotrexate (TrGO-MTX), through amide bonding. Thiolation of graphene oxide (GO) was achieved by transesterification process. The introduction of sulfur containing chemical groups and the partial reduction of GO to TrGO were proven by analytical techniques. Thiol content was found to be 6.98 mM by Ellman’s method in a quantitative manner. Furthermore, antineoplastic action of TrGO-MTX against human glioblastoma astrocytom U-373 MG cell line was studied, wherein TrGO-MTX demonstrated significant inhibition rate as compared with pure MTX.
|Journal||International Journal of Polymeric Materials and Polymeric Biomaterials|
|Publication status||Published - 02-07-2019|
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Chemical Engineering(all)
- Polymers and Plastics