Design and in vitro evaluation of floating drug delivery system for an antipsychotic agent: A technical report

M. Kar, M.S. Reddy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Floating drug delivery systems are used to target drug release in the stomach or to the upper parts of the intestine. The oral delivery of the anti-psychotic agent carbamazepine was facilitated by preparing a non-disintegrating floating dosage form which can increase its absorption in the stomach by increasing the drug's gastric residence time. The polymers used were HPMC (low and high viscosity), guar gum, and carbopol, along with sodium bicarbonate as the gas-generating agent. The prepared tablets were evaluated for their physicochemical properties and drug release. In vitro release studies indicated that the carbamazepine release from the floating dosage forms was uniform and followed a zero-order release. It was observed that the devices containing higher proportions of HPMC (high viscosity) showed slower release than those containing lower proportions while also maintaining the integrity of the device (≥24 h). The incorporation of guar gum helps to maintain the device's integrity, and due to its viscolysing property also affects the drug's release profile. Sodium bicarbonate which was used as the gas-generating agent causes the tablet to float for the required time (≥24 h).
Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalPDA Journal of Pharmaceutical Science and Technology
Volume60
Issue number6
Publication statusPublished - 2006

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guar gum
Drug Delivery Systems
Antipsychotic Agents
Sodium Bicarbonate
Carbamazepine
Dosage Forms
Viscosity
Equipment and Supplies
Tablets
Gases
Gastrointestinal Agents
Intestines
Stomach
Polymers
In Vitro Techniques
Drug Liberation

Cite this

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title = "Design and in vitro evaluation of floating drug delivery system for an antipsychotic agent: A technical report",
abstract = "Floating drug delivery systems are used to target drug release in the stomach or to the upper parts of the intestine. The oral delivery of the anti-psychotic agent carbamazepine was facilitated by preparing a non-disintegrating floating dosage form which can increase its absorption in the stomach by increasing the drug's gastric residence time. The polymers used were HPMC (low and high viscosity), guar gum, and carbopol, along with sodium bicarbonate as the gas-generating agent. The prepared tablets were evaluated for their physicochemical properties and drug release. In vitro release studies indicated that the carbamazepine release from the floating dosage forms was uniform and followed a zero-order release. It was observed that the devices containing higher proportions of HPMC (high viscosity) showed slower release than those containing lower proportions while also maintaining the integrity of the device (≥24 h). The incorporation of guar gum helps to maintain the device's integrity, and due to its viscolysing property also affects the drug's release profile. Sodium bicarbonate which was used as the gas-generating agent causes the tablet to float for the required time (≥24 h).",
author = "M. Kar and M.S. Reddy",
note = "Cited By :6 Export Date: 10 November 2017 CODEN: JPHTE Correspondence Address: Kar, M.; Department of Pharmacy, Mohan Lal Sukhadia University, Udaipur 313001, India; email: karmousumi@hotmail.com Chemicals/CAS: carbamazepine, 298-46-4, 8047-84-5; Antipsychotic Agents; Carbamazepine, 298-46-4; Delayed-Action Preparations; Excipients References: Khanna, S., Agrawal, P., Anticonvulsants in pregnancy and lactation (1997) Psychiatry Today, 1, pp. 39-41; Shastri, C., Aggrawal, A.K., Khandelwal, S.K., Bhashyam, V.S.P., Channabasavanna, Report from symposium on 'compliance issues in schizophrenia' (1997) Psychiatry Today, 1, pp. 53-64; Anand, V., Kandarapu, R., Garg, S., Ion Exchange resins: Carrying drug delivery forward (2001) Drug Del. Today, 6, pp. 910-911; Levy, R.H., Pitlick, W.H., Troupin, A.S., Pharmacokinetics of carbamazepine in normal man (1975) Clin. Pharmacol. Ther., 17 (6), pp. 657-658; Kobayashi, Y., Ito, S., Itai, S., Tamamato, K., Physicochemical properties and bioavailability of carbamazepine polymorphs and dihydrate (2000) Int. J. Pharm., 193, pp. 137-146; Desai, S., Bolton, S., A floating controlled release drug delivery system, in vitro-in vivo evaluation (1993) Pharm. Res., 10, pp. 1321-1325; Wan, L.S.C., Heng, P.W.S., Wong, L.F., Matrix swelling; a simple model describing extent of swelling of HPMC matrices (1995) Int. J. Pharm., 116, pp. 159-168; Venkatesh Nath, B.S., Doddayya, H.R.S., Hydroxy propyl methyl cellulose as wicking agent in matrix tablets of cetyl alcohol (1999) Indian Drugs, 36, pp. 720-722; Giunchedi, P., Conte, U., La Manna, a swellable polymer as carbamazepine dissolution rate enhancer (1990) Boll. Chim. Farm., 129, pp. 17-20; Jimenez-Castellanos, R.M., Zia, H., Rhodes, T.C., Design and testing in-vitro of a bioadhesive and floating drug delivery system for oral application (1994) Int. J. Pharm., 105, pp. 65-70; Chaudary, R.S., Jindal, K.C., Khanna, S., Stability testing of pharmaceuticals (1994) The East. Pharm., 37, pp. 65-67; Fell, J.T., Targeting of drugs and delivery systems to specific sites in the gastrointestinal tract (1996) Journal of Anatomy, 189 (3), pp. 517-519; Nur, A.O., Zhang, J.S., Captopril floating and/or bioadhesive tablets: Design and release kinetics (2000) Drug Dev. Ind. Pharm., 26, pp. 965-969",
year = "2006",
language = "English",
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issn = "1079-7440",
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AU - Kar, M.

AU - Reddy, M.S.

N1 - Cited By :6 Export Date: 10 November 2017 CODEN: JPHTE Correspondence Address: Kar, M.; Department of Pharmacy, Mohan Lal Sukhadia University, Udaipur 313001, India; email: karmousumi@hotmail.com Chemicals/CAS: carbamazepine, 298-46-4, 8047-84-5; Antipsychotic Agents; Carbamazepine, 298-46-4; Delayed-Action Preparations; Excipients References: Khanna, S., Agrawal, P., Anticonvulsants in pregnancy and lactation (1997) Psychiatry Today, 1, pp. 39-41; Shastri, C., Aggrawal, A.K., Khandelwal, S.K., Bhashyam, V.S.P., Channabasavanna, Report from symposium on 'compliance issues in schizophrenia' (1997) Psychiatry Today, 1, pp. 53-64; Anand, V., Kandarapu, R., Garg, S., Ion Exchange resins: Carrying drug delivery forward (2001) Drug Del. Today, 6, pp. 910-911; Levy, R.H., Pitlick, W.H., Troupin, A.S., Pharmacokinetics of carbamazepine in normal man (1975) Clin. Pharmacol. Ther., 17 (6), pp. 657-658; Kobayashi, Y., Ito, S., Itai, S., Tamamato, K., Physicochemical properties and bioavailability of carbamazepine polymorphs and dihydrate (2000) Int. J. Pharm., 193, pp. 137-146; Desai, S., Bolton, S., A floating controlled release drug delivery system, in vitro-in vivo evaluation (1993) Pharm. Res., 10, pp. 1321-1325; Wan, L.S.C., Heng, P.W.S., Wong, L.F., Matrix swelling; a simple model describing extent of swelling of HPMC matrices (1995) Int. J. Pharm., 116, pp. 159-168; Venkatesh Nath, B.S., Doddayya, H.R.S., Hydroxy propyl methyl cellulose as wicking agent in matrix tablets of cetyl alcohol (1999) Indian Drugs, 36, pp. 720-722; Giunchedi, P., Conte, U., La Manna, a swellable polymer as carbamazepine dissolution rate enhancer (1990) Boll. Chim. Farm., 129, pp. 17-20; Jimenez-Castellanos, R.M., Zia, H., Rhodes, T.C., Design and testing in-vitro of a bioadhesive and floating drug delivery system for oral application (1994) Int. J. Pharm., 105, pp. 65-70; Chaudary, R.S., Jindal, K.C., Khanna, S., Stability testing of pharmaceuticals (1994) The East. Pharm., 37, pp. 65-67; Fell, J.T., Targeting of drugs and delivery systems to specific sites in the gastrointestinal tract (1996) Journal of Anatomy, 189 (3), pp. 517-519; Nur, A.O., Zhang, J.S., Captopril floating and/or bioadhesive tablets: Design and release kinetics (2000) Drug Dev. Ind. Pharm., 26, pp. 965-969

PY - 2006

Y1 - 2006

N2 - Floating drug delivery systems are used to target drug release in the stomach or to the upper parts of the intestine. The oral delivery of the anti-psychotic agent carbamazepine was facilitated by preparing a non-disintegrating floating dosage form which can increase its absorption in the stomach by increasing the drug's gastric residence time. The polymers used were HPMC (low and high viscosity), guar gum, and carbopol, along with sodium bicarbonate as the gas-generating agent. The prepared tablets were evaluated for their physicochemical properties and drug release. In vitro release studies indicated that the carbamazepine release from the floating dosage forms was uniform and followed a zero-order release. It was observed that the devices containing higher proportions of HPMC (high viscosity) showed slower release than those containing lower proportions while also maintaining the integrity of the device (≥24 h). The incorporation of guar gum helps to maintain the device's integrity, and due to its viscolysing property also affects the drug's release profile. Sodium bicarbonate which was used as the gas-generating agent causes the tablet to float for the required time (≥24 h).

AB - Floating drug delivery systems are used to target drug release in the stomach or to the upper parts of the intestine. The oral delivery of the anti-psychotic agent carbamazepine was facilitated by preparing a non-disintegrating floating dosage form which can increase its absorption in the stomach by increasing the drug's gastric residence time. The polymers used were HPMC (low and high viscosity), guar gum, and carbopol, along with sodium bicarbonate as the gas-generating agent. The prepared tablets were evaluated for their physicochemical properties and drug release. In vitro release studies indicated that the carbamazepine release from the floating dosage forms was uniform and followed a zero-order release. It was observed that the devices containing higher proportions of HPMC (high viscosity) showed slower release than those containing lower proportions while also maintaining the integrity of the device (≥24 h). The incorporation of guar gum helps to maintain the device's integrity, and due to its viscolysing property also affects the drug's release profile. Sodium bicarbonate which was used as the gas-generating agent causes the tablet to float for the required time (≥24 h).

M3 - Article

VL - 60

SP - 389

EP - 394

JO - PDA Journal of Pharmaceutical Science and Technology

JF - PDA Journal of Pharmaceutical Science and Technology

SN - 1079-7440

IS - 6

ER -