Design of multifunctionalized piperazine polymer and its activity toward pathogenic microorganisms

Manohara Dhulappa Jalageri, Yashoda Malgar Puttaiahgowda, Ajithkumar Manayan Parambil, Ananda Kulal

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The study intends to design a simple and powerful synthesis of piperazine-methacrylate monomer and its homopolymer. The synthesized piperazine-methacrylate monomer was polymerized by solution polymerization technique in the presence of free-radical initiator azobis(2-methylpropionitrile) resulting in the formation of multifunctionalized piperazine polymer. The structural investigation was done by FTIR and NMR ( 1 H and 13 C NMR). The thermal properties and degradation of the polymer were examined by DSC and TGA techniques. The polymer exhibited glass transition temperature (T g ) at 88.4 °C. The polymer surface was found to be soft and nonporous which was examined by FESEM. The synthesized polymeric compound exhibited good antimicrobial activity against Gram-negative bacterium Escherichia coli, tubercular variant Mycobacterium smegmatis, and Gram-positive bacterium Staphylococcus aureus with a zone of inhibition at a range of 15.60–19.33, 15.33–17, and 15.67–18 mm diameter, respectively. The polymer also showed good activity against fungus Candida albicans with a zone of inhibition at a range of 16.33–22 mm diameter. The percentage inhibition of microorganisms increased with increase in concentration (1.5–12 mg) which is carried out by optical density method.

Original languageEnglish
Article number47521
JournalJournal of Applied Polymer Science
Volume136
Issue number19
DOIs
Publication statusPublished - 15-05-2019

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry

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