Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis

T. N.V. Ganesh Kumar, G. Gautham Shenoy, Sidhartha Sankar Kar, Vishnu Shenoy, Indira Bairy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.

Original languageEnglish
Pages (from-to)907-917
Number of pages11
JournalPharmaceutical Chemistry Journal
Volume51
Issue number10
DOIs
Publication statusPublished - 01-01-2018

Fingerprint

Econazole
Mycobacterium tuberculosis
Antitubercular Agents
Azoles
Mycobacterium
Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
1,2,4-triazole

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

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abstract = "Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.",
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Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis. / Ganesh Kumar, T. N.V.; Gautham Shenoy, G.; Kar, Sidhartha Sankar; Shenoy, Vishnu; Bairy, Indira.

In: Pharmaceutical Chemistry Journal, Vol. 51, No. 10, 01.01.2018, p. 907-917.

Research output: Contribution to journalArticle

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