Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis

T. N.V. Ganesh Kumar, G. Gautham Shenoy, Sidhartha Sankar Kar, Vishnu Shenoy, Indira Bairy

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3 Citations (Scopus)


Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.

Original languageEnglish
Pages (from-to)907-917
Number of pages11
JournalPharmaceutical Chemistry Journal
Issue number10
Publication statusPublished - 01-01-2018


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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