Design, synthesis, and evaluation of novel 6-chloro-/fluorochromone derivatives as potential topoisomerase inhibitor anticancer agents

M.P.S. Ishar, G. Singh, S. Singh, K.K. Sreenivasan

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

6-Chloro-2-pyrrolidino-/morpholino-/piperidino-/N-methylpiperazino-3- formyl-chromones (13-16) and 6-fluoro-2,7-di-morpholino-/piperidino-/N- methylpiperazino-3-formylchromones (17-19) have been synthesized as potential topoisomerase inhibitor anticancer agents, and evaluated, in vitro, against Ehrlich ascites carcinoma (EAC) cells, and also in vivo on EAC bearing mice. The compounds displayed promising anticancer activity under these test systems and shall serve as useful 'leads' for further design. © 2005 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)1366-1370
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number5
DOIs
Publication statusPublished - 2006
Externally publishedYes

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